Cannabinoid lozenge formulation
The present invention relates to a lozenge composition for controlled release of cannabinoids containing i) a master granule component including one or more solid particles and one or more cannabinoids reversibly associated with the one or more solid particles; and ii) an extragranular component blended with the master granule component that includes one or more extragranular sugar alcohols.
1 . A lozenge composition for controlled release of cannabinoids comprising:
i) a master granule component consisting of one or more non-dissolved solid particles and one or more cannabinoids dissolved in a lipid carrier that is adsorbed to a surface of the one or more non-dissolved solid particles; and
ii) an extragranular component comprising one or more extragranular water-soluble ingredients,
wherein the master granule component is present in a mixture with the extragranular component in the lozenge composition, and
wherein the one or more non-dissolved solid particles are selected from one or more sugars or one or more sugar alcohols.
2 . The lozenge composition according to claim 1 , wherein the one or more sugar alcohols are selected from the group consisting of xylitol, lactitol, sorbitol, maltitol, erythritol, isomalt and mannitol, and mixtures and combinations thereof.
3 . The lozenge composition according to claim 1 , wherein the one or more sugars are selected from the group consisting of dextrose, sucrose, maltose, fructose, lactose, and mixtures and combinations thereof.
4 . The lozenge composition according to claim 1 , wherein the master granule component is a premixture of the one or more non-dissolved solid particles and the one or more cannabinoids, the one or more cannabinoids being applied to the surface of the one or more non-dissolved solid particles by means of spraying.
5 . The lozenge composition according to claim 1 , wherein the lozenge composition does not comprise a polymer carrier for the one or more cannabinoids.
6 . The lozenge composition according to claim 1 , wherein the one or more non-dissolved solid particles are agglomerated to form granules comprising the one or more cannabinoids.
7 . The lozenge composition according to claim 1 , wherein the lipid carrier comprises one or more terpenes.
8 . The lozenge composition according to claim 1 , wherein a weight ratio of the one or more cannabinoids relative to the one or more non-dissolved solid particles is from 1:30 to 1:1.
9 . The lozenge composition according to claim 1 , wherein the one or more non-dissolved solid particles of the master granule component have a volume weighted mean diameter of 10-400 μm.
10 . The lozenge composition according to claim 1 , wherein the one or more cannabinoids is selected from the group consisting of cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), and mixtures and combinations thereof.
11 . The lozenge composition according to claim 1 , wherein the one or more cannabinoids is selected from the group consisting of tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), and mixtures and combinations thereof.
12 . A powder composition for controlled release of cannabinoids comprising:
i) a master granule component consisting of one or more non-dissolved solid particles and one or more cannabinoids dissolved in a lipid carrier that is adsorbed to a surface of the one or more non-dissolved solid particles; and
ii) an extragranular component comprising one or more extragranular water-soluble ingredients,
wherein the master granule component is present in a mixture with the extragranular component in the powder composition, and
wherein the one or more non-dissolved solid particles are selected from one or more sugars or one or more sugar alcohols.
13 . The powder composition according to claim 12 , wherein a weight ratio of the master granule component relative to the extragranular component is from 1:30 to 1:2.
14 . The powder composition according to claim 12 , wherein the one or more non-dissolved solid particles comprises one or more sugar alcohols in an amount of 5 to 40% by weight of the powder composition and the one or more extragranular water-soluble ingredients comprises one or more sugar alcohols in an amount of 60 to 95% by weight of the of the powder composition.
15 . A lozenge composition for controlled release of cannabinoids comprising;
i) a master granule component premixture consisting of one or more non-dissolved solid particles and one or more cannabinoids adsorbed to a surface of the one or more non-dissolved solid particles; and
ii) an extragranular component comprising one or more extragranular water-soluble ingredients,
wherein the master granule component is present in a mixture with the extragranular component in the lozenge composition,
wherein the one or more non-dissolved solid particles are selected from one or more sugars or one or more sugar alcohols, and
wherein a weight ratio of the master granule component premixture relative to the extragranular component is from 1:30 to 1:2.
16 . The lozenge composition according to claim 15 , wherein the weight ratio of the master granule component premixture relative to the extragranular component is from 1:20 to 1:3.
17 . The lozenge composition according to claim 15 , wherein the one or more cannabinoids are applied in a layer to the surface of the one or more non-dissolved solid particles comprised in the master granule component premixture before blending with the extragranular component.
18 . The lozenge composition according to claim 15 , wherein the lozenge composition does not comprise a polymer carrier for the one or more cannabinoids.
19 . The lozenge composition according to claim 15 , wherein the one or more cannabinoids comprises at least one isolated cannabinoid.
20 . The lozenge composition according to claim 15 , wherein the one or more non-dissolved solid particles comprises one or more sugar alcohols in an amount of 5 to 40% by weight of the powder composition and the one or more extragranular water-soluble ingredients comprises one or more sugar alcohols in an amount of 60 to 95% by weight of the of the lozenge composition.
21 . The lozenge composition according to claim 15 , wherein the one or more non-dissolved solid particles comprises one or more sugar alcohols in an amount of 20 to 40% by weight of the powder composition and the one or more extragranular water-soluble ingredients comprises one or more sugar alcohols in an amount of 60 to 80% by weight of the of the lozenge composition.
22 . The lozenge composition according to claim 15 , wherein the one or more non-dissolved solid particles are selected from the group consisting of xylitol, lactitol, sorbitol, maltitol, erythritol, isomalt and mannitol, and mixtures and combinations thereof.
23 . The lozenge composition according to claim 15 , wherein the one or more cannabinoids is selected from the group consisting of cannabidiol (CBD), cannabidiolic acid (CBDA), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabigerol (CBG), cannabichromene (CBC), cannabinol (CBN), cannabielsoin (CBE), iso-tetrahydrocannabinol (iso-THC), cannabicyclol (CBL), cannabicitran (CBT), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), and mixtures and combinations thereof.