IP Library › Granted Patent US 11,819,522
Granted Patent B2
US 11,819,522 · App. 17/568,553 · Granted Nov 21, 2023

Compositions and methods for treating and preventing tissue injury and disease

Inventors: Dale R. Peterson (Carlsbad, CA); Ralph-Heiko Mattern (Ramona, CA); Kevin L Ohashi (Jamaica Plain, MA); Lael J. Pickett (White Bear Lake, MN); Glen Gong (San Carlos, CA); Mohammad A. El-Kalay (Carlsbad, CA)
Assignee: MicroVascular Tissues, Inc.
A61K35/44A61K35/12A61K35/545A61L27/3625A61L27/3687A61L27/3691A61L27/3834A61L27/3878A61L27/54C12N5/0653A61L2300/41A61L2300/412A61L2400/06A61L2430/02A61L2430/06A61L2430/10A61L2430/32A61L2430/34A61L2430/38
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Quick Facts
Patent No.
US 11,819,522
App. No.
17/568,553
Granted
Nov 21, 2023
Kind
B2
Abstract

The present invention provides novel compositions comprising multipotent cells or microvascular tissue, wherein the cells or tissue has been sterilized and/or treated to inactivated viruses, and related methods of using these compositions to treat or prevent tissue injury or disease in an allogeneic subject.

Claims (18)

1. A composition, comprising isolated microvascular tissue, wherein the composition undergoes sterilization.

2. The composition of claim 1 , wherein sterilization comprises irradiation.

3. The composition of claim 2 , wherein irradiation is at a dose exceeding 0.5 Mrad.

4. The composition of claim 1 , wherein the composition retains angiogenic activity.

5. The composition of claim 1 , wherein the composition retains anti-inflammatory activity.

6. The composition of claim 1 , wherein the composition retains tissue healing activity.

7. The composition of claim 1 , wherein the composition is dried.

8. The composition of claim 7 , wherein the composition comprises a flexible biocompatible scaffold.

9. The composition of claim 8 , wherein the flexible biocompatible scaffold is a fabric sheet.

10. The composition of claim 1 , comprising a gel.

11. The composition of claim 10 , wherein the gel is suitable for topical delivery.

12. The composition of claim 1 , wherein the isolated microvascular tissue includes removal or lysis of adipocytes.

13. A method of treating a soft-tissue injury in a subject in need thereof, comprising administering the composition of claim 1 to the subject.

14. The method of claim 13 , wherein the soft-tissue injury is tendinopathy.

15. The method of claim 13 , wherein the soft-tissue injury is neuropathy.

16. The method of claim 13 , wherein the soft-tissue injury is ischemia.

17. A method of treating a bone defect in a subject in need thereof, comprising administering the composition of claim 1 to the subject.

18. A method of treating arthritis in a subject in need thereof, comprising administering the composition of claim 1 to the subject.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2022
From: PETERSON, DALE R.; MATTERN, RALPH-HEIKO; OHASHI, KEVIN L.; PICKETT, LAEL J.; GONG, GLEN; EL-KALAY, MOHAMMAD A.
To: MICROVASCULAR TISSUES, INC.
Reel/Frame 062148/0773 →
Continuity (6)
Continuation 16780718 · Feb 3, 2020
Division 15865220 · Jan 8, 2018
Continuation In Part 15633311 · Jun 26, 2017
Continuation 14429511
Provisional Application 61703203 · Sep 19, 2012
Related Publication 20220323508A1 · Oct 13, 2022
Cited By (1)
US 12,364,716