IP Library › Granted Patent US 12,377,208
Granted Patent B2
US 12,377,208 · App. 17/569,572 · Granted Aug 5, 2025

Single actuated precision dose intermediate pumping chamber

Inventor: David Nazzaro (Groveland, MA)
Assignee: INSULET CORPORATION
A61M5/14216A61M5/14244A61M5/1452A61M2205/0266
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Quick Facts
Patent No.
US 12,377,208
App. No.
17/569,572
Granted
Aug 5, 2025
Kind
B2
Abstract

Disclosed are examples of devices, systems and techniques for delivering a liquid drug. An example delivery pump device may include a chamber body defining a pump chamber, an inlet valve to receive a liquid drug and a hard stop. A plunger configured with a plunger channel. A sliding fluidic member including a needle coupling, a flow orifice, a face seal and an anchor portion that may be movable within the pump chamber. A pump mechanism may be coupled to the anchor portion and operable to pull the anchor portion and the plunger toward the hard stop. Techniques may include determining a time to output a liquid drug from the delivery pump device; generating a control signal to actuate the delivery pump device; applying a control signal to the pump mechanism; determining that a control signal is to be removed from the pump mechanism; and delivering the liquid drug.

Claims (62)

1. A wearable drug delivery device, comprising:

a reservoir configured to store a liquid drug; and

a delivery pump device coupled to the reservoir for receiving the liquid drug from the reservoir, the delivery pump device comprising:

a chamber body defining a pump chamber,

an inlet port configured to enable a liquid drug from the reservoir to be drawn into the pump chamber,

a sliding fluidic member including a flow orifice and a fluid pathway to a needle,

a plunger including a plunger channel configured to be engaged with the sliding fluidic member, and

a shape memory alloy wire coupled to the sliding fluidic member,

wherein:

the shape memory alloy wire is operable to draw the liquid drug from the reservoir through the inlet port and into the pump chamber by pulling the sliding fluidic member and the plunger in a first direction, and

the sliding fluidic member is configured to enable the liquid drug to be drawn into the pump chamber and expelled from the pump chamber into a fluid pathway to a needle for output.

2. The wearable drug delivery device of claim 1 , wherein the sliding fluidic member further comprises:

a face seal that is configured to maintain a fluid-proof seal against a first plunger surface of the plunger as the shape memory alloy wire pulls an anchor portion.

3. The wearable drug delivery device of claim 1 , wherein the sliding fluidic member further comprises:

an anchor portion coupled to the shape memory alloy wire, wherein the anchor portion is configured to engage the plunger by traversing into a plunger channel of the plunger in response to the pull by the shape memory alloy wire; and

a needle coupling connected to an anchor portion.

4. The wearable drug delivery device of claim 1 , wherein the plunger is configured to make direct physical contact with an interior surface of the chamber body to define the pumping chamber.

5. The wearable drug delivery device of claim 1 , further comprising:

a fluidic member spring having a first end coupled to an anchor portion; and

a plunger spring having a first end coupled to the plunger,

wherein the fluidic member spring and the plunger spring are configured to be pulled from a rest position to a compressed position by the shape memory alloy wire.

6. The wearable drug delivery device of claim 1 , further comprising:

a hard stop opposite the inlet port;

a fluidic member spring having a first end coupled to an anchor portion; and

a plunger spring having a first end coupled to the plunger,

wherein the hard stop is configured to contact a second end of the plunger spring, opposite the first end of the plunger spring and further configured to contact a second end of the fluidic member spring, opposite the first end of the fluidic member spring coupled to the plunger.

7. The wearable drug delivery device of claim 6 , wherein:

the hard stop further includes a hard stop flexure snap; and

the plunger further includes a plunger flexure snap,

wherein the plunger flexure snap and the hard stop flexure snap are configured to engage one another as the shape memory alloy wire pulls the anchor portion.

8. The wearable drug delivery device of claim 1 , wherein the inlet port further comprises a passive check valve.

9. The wearable drug delivery device of claim 1 , further comprising:

a power source coupled to the shape memory alloy, wherein power from the power source is applied to the shape memory alloy to cause the shape memory wire to contract and thereby pull an anchor portion.

10. The wearable drug delivery device of claim 6 , further comprising a controller communicatively coupled to a power source, wherein the controller is operable to:

activate the power source to cause power to be applied to the shape memory alloy in response to an automated insulin delivery application setting.

11. A delivery pump device of a wearable drug delivery device, the delivery pump device comprising:

a chamber body defining a pump chamber, the chamber body including a hard stop and an inlet valve operable to receive a liquid drug from a reservoir;

a plunger movable within the pump chamber of the chamber body and configured with a plunger channel;

a sliding fluidic member movable within the pump chamber and including a needle coupling, a flow orifice, a face seal and an anchor portion, wherein the anchor portion is positioned and movable within the plunger channel in a leak-proof configuration; and

a shape memory alloy wire coupled to the anchor portion, wherein the shape memory alloy wire is operable to pull the anchor portion and the plunger toward the hard stop.

12. The delivery pump device of claim 11 , wherein the face seal is configured to maintain a leak-proof seal against a first surface of the plunger to form the leak-proof configuration.

13. The delivery pump device of claim 11 , the plunger further comprising:

a plunger hard stop that is configured to engage the hard stop of the housing; and

a plunger spring, wherein the plunger spring is in a compressed position when the plunger hard stop engages the hard stop of the chamber body.

14. The delivery pump device of claim 11 , wherein the shape memory alloy wire is configured to:

pull the sliding fluidic member and the plunger in a first direction away from a front of the chamber body in response to application of a current to the shape memory alloy wire, wherein the liquid drug is drawn from the reservoir through the inlet valve into the pump chamber; and

stop pulling the sliding fluidic member and the plunger in response to the current no longer being applied to the shape memory wire, wherein the pump chamber is filled with the liquid drug.

15. The delivery pump device of claim 14 , further comprising:

a plunger spring; and

a fluidic member spring,

wherein:

the plunger spring is configured to contact a hard stop of the chamber body,

the fluidic member spring is configured to contact the hard stop of the chamber body, and

when the shape memory alloy wire stops pulling the sliding fluidic member, the plunger spring and the fluidic member spring are compressed.

16. The delivery pump device of claim 15 , wherein the delivery pump device is further configured to:

in response to the shape memory alloy stopping pulling the sliding fluidic member, the fluidic member spring begins decompressing causing the sliding fluidic member to travel toward the front of the chamber body, while the plunger remains stationary due to being hydraulically blocked by the liquid drug in the pump chamber.

17. The delivery pump device of claim 16 , wherein the delivery pump device is further configured to:

upon the sliding fluidic member reaching an initial position, the flow orifice is available to enable the liquid drug to flow into the needle coupling; and

the plunger spring begins to decompress causing liquid drug to be expelled from the pump chamber into the needle coupling.

18. The wearable drug delivery device of claim 10 , further comprising:

a first fluid path component connecting the reservoir with an inlet port of the housing; and

a second fluid path component connecting an outlet port of the housing with a cannula, wherein the inlet valve is positioned within the inlet port, and wherein the outlet valve is positioned within the outlet port.

Assignments (2)
SECURITY AGREEMENT SUPPLEMENT Recorded Dec 1, 2022
From: INSULET CORPORATION
To: MORGAN STANLEY SENIOR FUNDING, INC., AS COLLATERAL AGENT
Reel/Frame 062035/0785 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 7, 2022
From: NAZZARO, DAVID
To: INSULET CORPORATION
Reel/Frame 058572/0195 →
Continuity (2)
Provisional Application 63135081 · Jan 8, 2021
Related Publication 20220218897A1 · Jul 14, 2022
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