IP Library › Granted Patent US 12,251,228
Granted Patent B2
US 12,251,228 · App. 17/570,871 · Granted Mar 18, 2025

Systems and methods for fetal monitoring

Inventors: Paul A. Friedman (Rochester, MN); Dorothy J. Ladewig (Mazeppa, MN); Itzhak Zachi Attia (Rochester, MN); Kyle D. Traynor (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research
A61B5/344A61B5/0006A61B5/332A61B5/349A61B5/6898A61B5/02411A61B5/339A61B5/4362A61B5/4845A61B5/7278
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Quick Facts
Patent No.
US 12,251,228
App. No.
17/570,871
Granted
Mar 18, 2025
Kind
B2
Abstract

A system obtains a maternal electrocardiogram (ECG) signal that represents an ECG of a pregnant mother during a first time interval. The system further obtains a mixed maternal-fetal ECG signal that represents a combined ECG of the mother and her fetus during the first time interval; processes the maternal ECG signal and the mixed maternal-fetal ECG signal to generate a fetal ECG signal that represents the ECG of the fetus during the time interval, the fetal ECG signal substantially excluding the maternal ECG signal; and provides an output based on the fetal ECG signal.

Claims (36)

1. A method, comprising:

obtaining at least one channel of a maternal electrocardiogram (ECG) signal that represents an ECG of a pregnant mother during a first time interval, wherein the maternal ECG signal is acquired from a first set of electrodes affixed to at least one of an abdominal region of the mother or a chest region of the mother;

obtaining at least one channel of a mixed maternal-fetal ECG signal that represents a combined ECG of the mother and her fetus during the first time interval, wherein the mixed maternal-fetal ECG signal is acquired from a second set of electrodes;

synchronizing multiple channels of at least one of the maternal ECG signal or the mixed maternal-fetal ECG signal thereby aligning beats from the multiple channels in time;

processing synchronized channels of the maternal ECG signal and the mixed maternal-fetal ECG signal to generate a fetal ECG signal that represents the ECG of the fetus during the time interval, the fetal ECG signal substantially excluding the maternal ECG signal; and

providing an output based on the fetal ECG signal.

2. The method of claim 1 , wherein the system comprises a smartphone or a tablet computing device.

3. The method of claim 1 , wherein processing the maternal ECG signal and the mixed maternal-fetal ECG signal to generate the fetal ECG signal comprises subtracting the maternal ECG signal from the mixed maternal-fetal ECG signal to generate the fetal ECG signal.

4. The method of claim 1 , further comprising applying an adaptive filter to the maternal ECG signal before subtracting the maternal ECG signal from the mixed maternal-fetal ECG signal.

5. The method of claim 1 , wherein the adaptive filter comprises a Wiener filter.

6. The method of claim 1 , wherein processing the maternal ECG signal and the mixed maternal-fetal ECG signal to generate the fetal ECG signal comprises using a blind source separation technique to separate the fetal ECG signal from the maternal ECG signal.

7. The method of claim 1 , wherein processing the maternal ECG signal and the mixed maternal-fetal ECG signal to generate the fetal ECG signal comprises using of a principal component analysis (PCA) technique.

8. The method of claim 1 , further comprising analyzing the fetal ECG signal to determine a distress level of the fetus; and

wherein providing the output comprises generating an alert for presentation to a human user in response to a determination that the determined distress level of the fetus exceeds a threshold distress level.

9. The method of claim 1 , further comprising:

processing the fetal ECG signal to determine a representative fetal beat based on a combination of multiple beats from the fetal ECG signal; and

processing the representative fetal beat to predict one or more fetal conditions.

10. The method of claim 9 , wherein the one or more fetal conditions comprise at least one of fetal acidemia, fetal pO 2 , fetal pH, or fetal cardiac anomalies.

11. The method of claim 9 , wherein the representative fetal beat is determined by identifying a set of beats from the fetal ECG signal, excluding noisy beats from the set, and averaging the non-excluded beats from the set.

12. The method of claim 9 , wherein processing the representative fetal beat comprises determining values of one or more features of the representative fetal beat, and providing the values of the one or more features of the representative fetal beat to a model configured to predict the one or more fetal conditions.

13. The method of claim 12 , wherein the one or more features of the representative fetal beat include at least one of a Q-T interval, a slope of an ascending portion of a T-wave, a slope of a descending portion of the T-wave, an amplitude of the T-wave, or an area under the T-wave.

14. The method of claim 1 , wherein obtaining the at least one channel of the mixed maternal-fetal ECG signal comprises:

digitally sampling a pre-amplified version of the mixed maternal-fetal ECG signal;

digitally sampling an amplified version of the mixed maternal-fetal ECG signal; and

combining the pre-amplified version of the mixed maternal-fetal ECG signal.

15. The method of claim 14 , wherein the amplified version of the mixed maternal-fetal ECG signal extends beyond a dynamic range of an analog-to-digital converter that digitally samples the amplified version.

16. The method of claim 1 , wherein the first set of electrodes include electrodes affixed to the chest region of the mother and the second set of electrodes includes electrodes affixed to the abdominal region of the mother.

17. A method, comprising:

receiving multiple channels of a first ECG signal, wherein the first ECG signal is a mixed maternal-fetal ECG signal that represents a combined ECG of a pregnant mother and her fetus, wherein the mixed maternal-fetal ECG signal was acquired using a first set of electrodes;

synchronizing the multiple channels of the first ECG signal thereby aligning beats from the multiple channels in time;

processing the multiple, synchronized channels of the first ECG signal to determine values for one or more features of the first ECG signal;

determining, based on the determined values for the one or more features of the first ECG signal, a condition of at least one of the mother or the fetus; and

providing an output based on the determined condition of the at least one of the mother or the fetus.

18. The method of claim 17 , wherein the features of the first ECG signal comprise features of a waveform for a beat from the first ECG signal, the features of the waveform including a slope or an area of a portion of the waveform for the beat.

19. The method of claim 17 , wherein determining the condition of the at least one of the mother or the fetus comprises accessing a model that correlates at least one of maternal conditions or fetal conditions with ECG signal features.

20. The method of claim 19 , wherein the model comprises an artificial neural network.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 1, 2022
From: FRIEDMAN, PAUL A.; LADEWIG, DOROTHY J.; ATTIA, ITZHAK ZACHI; TRAYNOR, KYLE D.
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 059129/0087 →
Continuity (3)
Continuation 16489600
Provisional Application 62464783 · Feb 28, 2017
Related Publication 20220125366A1 · Apr 28, 2022
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