IP Library › Granted Patent US 12,415,092
Granted Patent B2
US 12,415,092 · App. 17/575,074 · Granted Sep 16, 2025

Flash radiotherapy accelerator system

Inventors: Stephen E. Sampayan (Manteca, CA); George James Caporaso (East Quogue, NY); Yu-Jiuan Chen (Fremont, CA); Kristin Cortella Sampayan (Manteca, CA)
Assignees: Lawrence Livermore National Security, LLC; Opcondys, Inc.
A61N5/1048A61N5/1078H05H7/04H05H7/06H05H7/22A61N2005/1088A61N2005/1089H05H2277/11
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Quick Facts
Patent No.
US 12,415,092
App. No.
17/575,074
Granted
Sep 16, 2025
Kind
B2
Abstract

Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One radiotherapy system includes a particle accelerator configured to receive charged particles from a pulsed source. The particle accelerator includes a pipe configured to allow the charged particles to pass through as a beam, a magnetic core positioned proximate to the pipe and coupled to the pulsed source, and at least one multilayer insulator positioned adjacent to the pipe and the magnetic core. The system also includes a photoconductive switch coupled to the particle accelerator and configured to supply the particle accelerator with a plurality of voltage pulses.

Claims (41)

1. An accelerator system for use in a radiotherapy system, comprising:

a particle accelerator configured to receive charged particles from a pulsed source, wherein the particle accelerator comprises:

a pipe configured to allow the charged particles to pass through as a beam,

a magnetic core positioned proximate to the pipe and coupled to the pulsed source, and

a multilayer insulator positioned adjacent to the pipe and the magnetic core; and

a photoconductive switch coupled to the particle accelerator and configured to supply the particle accelerator with a plurality of voltage pulses, wherein the particle accelerator is operable to accelerate the charged particles based on the plurality of voltage pulses, and to produce an output beam comprising one or more radiation pulses for radiotherapy,

wherein the photoconductive switch includes a doped crystalline material that is configured to receive a voltage from an energy source to establish an electric field across the doped crystalline material, and

wherein the photoconductive switch is configured to receive light from a light source and to operate in response to the received light, the photoconductive switch being operable in a linear mode of operation in response to the received light,

wherein the accelerator system is operable to:

produce output radiation pulses with an instantaneous dose rate that exceeds 1.8×10 5 Gy/s,

administer a totality of the output radiation pulses that constitute a required dose in less than 200 ms,

produce the output radiation pulses with an average dose rate greater than 100 Gy/s, and

irradiate an entirety of a target region with levels above both the instantaneous dose rate and the average dose rate.

2. The accelerator system of claim 1 , wherein the particle accelerator comprises:

a solenoid coupled to the magnetic core that is positioned around the pipe, wherein the solenoid is positioned proximate to the magnetic core and the multilayer insulator, wherein the pulsed source is coupled to the magnetic core via the solenoid to enable the particle accelerator to receive the charged particles.

3. The accelerator system of claim 1 , wherein the light source includes one or more laser sources.

4. The accelerator system of claim 1 , wherein the photoconductive switch is operable to modify one or more of an amplitude, shape, spacing, number or width of the plurality of voltage pulses supplied to the particle accelerator.

5. The accelerator system of claim 1 , wherein the accelerator system has a three-dimensional footprint of less than or equal to 100 cubic meters.

6. The accelerator system of claim 1 , wherein the particle accelerator is an induction linear accelerator.

7. The accelerator system of claim 1 , wherein the charged particles comprise electrons.

8. The accelerator system of claim 1 , wherein the pipe is configured to accommodate multiple beams of charged particles.

9. A method for producing output radiation in a radiotherapy system, comprising:

receiving, at a particle accelerator of a particle accelerator system, a beam of charged particles from a particle source, wherein the particle accelerator comprises a pipe configured to allow the beam of charged particles to pass through, a magnetic core positioned proximate to the pipe and coupled to a pulsed source, and an insulator positioned adjacent to the pipe and the magnetic core, wherein the particle accelerator system further includes a photoconductive switch coupled to the particle accelerator that comprises a doped crystalline material that is configured to receive a voltage from an energy source to establish an electric field across the doped crystalline material;

producing a plurality of voltage pulses by the photoconductive switch in response to receiving light that is incident on the doped crystalline material; and

accelerating the beam of charged particles by the particle accelerator based on the plurality of voltage pulses to produce one or more output radiation beams for flash radiotherapy,

wherein the method further comprises:

producing the one or more output radiation beams that include radiation pulses with an instantaneous dose rate that exceed 1.8×105 Gy/s,

administering a required dose in less than 200 ms,

producing the one or more output radiation beams having radiation pulses with an average dose rate greater than 100 Gy/s, and

irradiating an entirety of a target region with levels above both the instantaneous dose rate and the average dose rate.

10. The method of claim 9 , wherein the photoconductive switch is configured to receive the light from a light source and to operate in response to the received light, the photoconductive switch being operable in a linear mode of operation in response to the received light.

11. The method of claim 10 , wherein the light source includes one or more laser sources.

12. The method of claim 9 , further comprising:

measuring a radiation amount administered to the entirety of the target region.

13. The method of claim 9 , comprising:

modifying an instantaneous dose rate or average dose rate of the one or more output radiation beams based on the plurality of voltage pulses produced by the photoconductive switch.

14. The method of claim 9 , wherein the particle accelerator is an induction linear accelerator.

15. The method of claim 9 , wherein the beam of charged particles comprise electrons.

16. The method of claim 9 , wherein the pipe is configured to accommodate multiple beams of charged particle beams.

17. The method of claim 9 , wherein the particle accelerator system has a three-dimensional footprint of less than or equal to 100 cubic meters, and the method further comprises:

operating the particle accelerator system in a clinical setting.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 16, 2022
From: SAMPAYAN, STEPHEN E.; CAPORASO, GEORGE JAMES; CHEN, YU-JIUAN
To: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
Reel/Frame 059915/0568 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 16, 2022
From: SAMPAYAN, KRISTIN CORTELLA
To: OPCONDYS, INC.
Reel/Frame 059915/0679 →
CONFIRMATORY LICENSE (SEE DOCUMENT FOR DETAILS) Recorded Feb 23, 2022
From: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
To: U.S. DEPARTMENT OF ENERGY
Reel/Frame 059220/0766 →
Continuity (2)
Provisional Application 63136645 · Jan 13, 2021
Related Publication 20220219014A1 · Jul 14, 2022
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