Anti-VEGF protein compositions and methods for producing the same
The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
1. A culture media composition comprising chemically defined media (CDM) and oxo-aflibercept, wherein one or more amino acid residues of aflibercept is oxidized and wherein said one or more amino acid residues is histidine and/or tryptophan.
2. A culture media composition of claim 1 , wherein said oxo-aflibercept is enzymatically digested resulting in one or more oligopeptides, and wherein said one or more oligopeptides selected from the group consisting of: SEQ ID NO. 17, SEQ ID NO. 18, SEQ ID NO. 19, SEQ ID NO. 20, SEQ ID NO. 21, SEQ ID NO. 22, SEQ ID NO. 23, SEQ ID NO. 28, SEQ ID NO. 29, SEQ ID NO. 30, SEQ ID NO. 31, SEQ ID NO. 32 and combinations thereof.
3. A culture media composition of claim 1 further comprising SEQ ID NO. 17.
4. A culture media composition of claim 1 further comprising SEQ ID NO. 18.
5. A culture media composition of claim 1 further comprising SEQ ID NO. 19.
6. A culture media composition of claim 1 further comprising SEQ ID NO. 20.
7. A culture media composition of claim 1 further comprising SEQ ID NO. 21.
8. A culture media composition of claim 1 further comprising SEQ ID NO. 22.
9. A culture media composition of claim 1 further comprising SEQ ID NO. 23.
10. A culture media composition of claim 1 further comprising SEQ ID NO. 28.
11. A culture media composition of claim 1 further comprising SEQ ID NO. 29.
12. A culture media composition of claim 1 further comprising SEQ ID NO. 30.
13. A culture media composition of claim 1 further comprising SEQ ID NO. 31.
14. A culture media composition of claim 1 further comprising SEQ ID NO. 32.