Granted Patent
B2
US 12,220,579 · App. 17/578,339 · Granted Feb 11, 2025
Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
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Abstract
Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.
Claims (23)
1. A device for reducing bleed time in a subject by simultaneously concurrently stimulating both a vagus nerve and a trigeminal nerve, the device comprising:
a housing configured to fit on or in an auricle region of an ear of the subject;
a vagus stimulator coupled to the housing and configured to be applied to the ear;
a trigeminal stimulator coupled to the housing and configured to be applied to the subject's face or head over a region innervated by the trigeminal nerve; and
a controller within the housing, the controller comprising control circuitry, power control circuitry, a waveform generator, a trigeminal stimulation drive and a vagus stimulation drive, wherein the control circuitry is configured to control the trigeminal stimulation drive and the vagus stimulation drive to coordinate concurrent application of activation from both the vagus stimulator and the trigeminal stimulator in a stimulation pattern configured to reduce bleed time in a subject.
2. The device of claim 1 , wherein controlling the trigeminal stimulation drive comprises driving the trigeminal stimulator at between 1-50 Hz and wherein controlling the vagus stimulation drive comprises driving the vagus stimulator at between 0.5-100 Hz.
3. The device of claim 1 , wherein the vagus stimulation drive is configured to electrically activate the vagus stimulator with a current having a pulse width of between 0.1 ms and 5 ms at between 0.5-100 Hz, and the trigeminal stimulation drive is configured to electrically activate the trigeminal stimulator with a current having a pulse width of between 0.1 ms and 5 ms at between 0.5-100 Hz.
4. The device of claim 1 , wherein the housing comprises an ear retainer configured to hold the device in or on the ear.
5. The device of claim 1 , further comprising a connector coupled to the trigeminal stimulator.
6. The device of claim 5 , wherein the connector comprises a cable.
7. The device of claim 1 , wherein the vagus stimulator is configured as an electrical stimulator comprising an electrode configured to couple to the subject's skin.
8. The device of claim 1 , wherein the vagus stimulator is configured as a mechanical stimulator.
9. The device of claim 1 , wherein the trigeminal stimulator is configured as an electrical stimulator comprising an electrode configured to couple to the subject's skin.
10. The device of claim 1 , wherein the trigeminal stimulator is configured as a mechanical stimulator.
11. The device of claim 1 , wherein the concurrent application comprises overlapping application.
12. The device of claim 1 , wherein controlling the trigeminal stimulation drive comprises driving the trigeminal stimulator at between 0.1-100 Hz.
13. The device of claim 1 , wherein controlling the vagus stimulation drive comprises driving the vagus stimulator at between 0.5-50 Hz.
14. The device of claim 1 , wherein the vagus stimulation drive is configured to electrically activate the vagus stimulator with a current having a pulse width of between 0.1 ms and 5 ms at between 0.5-100 Hz, and the trigeminal stimulation drive is configured to electrically activate the trigeminal stimulator with a current between 0.1 and 100 mA having a pulse width of between 0.1 ms and 5 ms at between 0.5-100 Hz.
15. A device for reducing bleed time in a subject by concurrently stimulating both a vagus nerve and a trigeminal nerve, the device comprising:
a housing configured to be worn by the subject;
a vagus stimulator coupled to the housing and configured to be applied to the ear;
a trigeminal stimulator coupled to the housing and configured to be applied to the subject's face or head over a region innervated by the trigeminal nerve; and
a controller within the housing, the controller comprising control circuitry, power control circuitry, a waveform generator, a trigeminal stimulation drive and a vagus stimulation drive, wherein the control circuitry is configured to control the trigeminal stimulation drive and the vagus stimulation drive to coordinate concurrent application of activation from both the vagus stimulator and the trigeminal stimulator in a stimulation pattern configured to reduce blood loss and/or bleeding volume.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 3, 2023
From: MANOGUE, KIRK R.
To: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
Reel/Frame 062590/0962 →
Continuity (3)
Provisional Application
62736447
· Sep 25, 2018
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