Neural stimulation devices and systems for treatment of chronic inflammation
A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.
1. A leadless, implantable microstimulator device, the device comprising:
a hermetically sealed capsule body;
an electrode saddle on a first side of the capsule body, wherein the electrode saddle comprises a first concave region comprising a first electrode and a second concave region comprising a second electrode;
a resonator within the sealed capsule body configured to resonate at a predetermined frequency range;
a battery within the sealed capsule body; and
an electronic assembly within the sealed capsule body;
wherein the electronic assembly comprises a microcontroller configured to control the application of electrical energy to a nerve held against the electrode saddle by applying energy between the first electrode and the second electrode.
2. The device of claim 1 , wherein the capsule body comprises a tubular body.
3. The device of claim 1 , wherein the capsule body comprises a Zirconia tube.
4. The device of claim 1 , wherein the first electrode is integrated into the first concave region and the second electrode is integrated into the second concave region.
5. The device of claim 1 , wherein the electrode saddle is integrally formed with the capsule body.
6. The device of claim 1 , wherein the electrode saddle is attached to an outside of the capsule body.
7. The device of claim 1 , wherein the first concave region of the electrode saddle is separated along a length of the capsule body by a non-concave gap region from the second concave region.
8. The device of claim 1 , wherein a surface area of the first electrode and the second electrode configured to electrically contact the nerve is greater than 15 mm 2 .
9. The device of claim 1 , wherein the microcontroller is configured to apply a dose of up to 5 mA.
10. The device of claim 1 , wherein a total volume of the device is less than 1.5 cubic centimeters (cc).
11. A leadless, implantable microstimulator device, the device comprising:
a hermetically sealed cylindrical capsule body;
an electrode saddle extending from a first side of the capsule body, wherein the electrode saddle comprises a first concave region comprising a first electrode and a second concave region comprising a second electrode;
a resonator within the sealed capsule body, the resonator comprising a coil and a capacitor configured to resonate at a predetermined frequency range;
a battery within the sealed capsule body; and
an electronic assembly within the sealed capsule body in electrical contact with the first and second electrodes;
wherein the electronic assembly comprises a microcontroller configured to control the application of electrical energy to a nerve held against the electrode saddle by applying energy between the first electrode and the second electrode and to control charging of the battery by the resonator.
12. The device of claim 11 , wherein the capsule body comprises a tubular body.
13. The device of claim 11 , wherein the capsule body comprises a Zirconia tube.
14. The device of claim 11 , wherein the first electrode is integrated into the first concave region and the second electrode is integrated into the second concave region.
15. The device of claim 11 , wherein the electrode saddle is integrally formed with the capsule body.
16. The device of claim 11 , wherein the electrode saddle is attached to an outside of the capsule body.
17. The device of claim 11 , wherein the first concave region of the electrode saddle is separated along a length of the capsule body by a non-concave gap region from the second concave region.
18. The device of claim 11 , wherein a surface area of the first electrode and the second electrode configured to electrically contact the nerve is greater than 15 mm 2 .
19. The device of claim 11 , wherein the microcontroller is configured to apply a dose of up to 5 mA.
20. The device of claim 11 , wherein a total volume of the device is less than 1.5 cubic centimeters (cc).