Granted Patent
B2
US 12,551,619 · App. 17/582,374 · Granted Feb 17, 2026
Automated insulin delivery system using pramlintide
Inventors:
Joon Bok Lee (Acton, MA); Jason O'Connor (Acton, MA); Yibin Zheng (Hartland, WI); Ashutosh Zade (San Diego, CA)
Assignee:
INSULET CORPORATION
A61M5/1723A61B5/14532A61B5/4839A61B5/4866A61B5/7282A61K38/22A61K38/26A61K38/28A61M5/1408A61M5/14248G16H20/17G16H40/67A61M2205/502A61M2205/52A61M2205/8206A61M2230/201
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Abstract
Disclosed herein are systems and methods for the delivery of insulin and pramlintide using an automated insulin delivery system. In a first embodiment, a drug delivery system is configured to deliver independent doses of insulin and pramlintide. The system monitors the user's blood glucose level and determines when a meal is been ingested and, in response, delivers the dose of pramlintide which, in turn alters the required delivery of insulin. In the second embodiment, the drug delivery system is configured to deliver a co-formulation of insulin and pramlintide as basal doses. The total amount of pramlintide delivered in a most recent pre-determine period of time, for example, 24 hours, is used to alter the aggressiveness of the algorithm which determines the basal doses of the co-formulation.
Claims (15)
1 . A system comprising:
a drug delivery device configured to deliver co-formulated doses of insulin and pramlintide to a user;
a sensor, for periodically measuring a blood glucose level of the user and
an algorithm, implemented by software executed by a processor, to determine the timing and quantity of the delivery of the co-formulation of the insulin and the pramlintide, wherein the algorithm determines when the user has ingested a meal based on an average over a predetermined threshold of one or more of: a predetermined rise in the blood glucose level of the user during a most recent predetermined time; a predetermined rise in the blood glucose level of the user over a target glucose reading; or a predetermined rise in a mean blood glucose level of the user over a predetermined time period over a mean glucose level of the user during a preceding predetermined time period.
2 . The system of claim 1 wherein the algorithm:
calculates a total quantity of pramlintide delivered during a most recent predetermined period of time; and
adjusts delivery of basal doses of the co-formulation based on the calculation.
3 . The system of claim 2 wherein the predetermined period of time is 24 hours.
4 . The system of claim 2 wherein the algorithm provides a more aggressive response to blood glucose excursions of the user based on a higher quantity of pramlintide being delivered to the user during the most recent predetermined period of time.
5 . The system of claim 2 wherein the algorithm decreases the quantity of the co-formulation delivered during a certain period of time based on the quantity of pramlintide being delivered to the user during the most recent predetermined period of time.
6 . The system of claim 1 wherein the algorithm controls delivery of basal dose of the co-formulation to the user based on the periodic blood glucose readings.
7 . The system of claim 1 , wherein the algorithm allows a higher dose of the co-formulation to be delivered to the user in response to sustained increases in the blood glucose readings of the user.
8 . The system of claim 1 , wherein the algorithm reduces the total amount of the co-formulation to be delivered to the user based on a sustained increase in the blood glucose readings of the user.
9 . The system of claim 1 wherein the algorithm directs the drug delivery device to deliver a dose the co-formulation of the insulin and the pramlintide to the user when the algorithm determines that the user has ingested a meal.
10 . The system of claim 1 wherein the determination that the user has ingested a meal is based on one or more of: a predetermined rise in the glucose readings of the user during most recent predetermined time; a predetermined rise in the glucose readings over a target glucose reading; or a predetermined rise in the mean glucose level of the user over a predetermined time period over the mean glucose level of the user during a preceding predetermined time period.
Assignments (2)
SECURITY AGREEMENT SUPPLEMENT
Recorded Dec 1, 2022
From: INSULET CORPORATION
To: MORGAN STANLEY SENIOR FUNDING, INC., AS COLLATERAL AGENT
Reel/Frame 062035/0785 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 31, 2022
From: LEE, JOON BOK; O'CONNOR, JASON; ZHENG, YIBIN; ZADE, ASHUTOSH
To: INSULET CORPORATION
Reel/Frame 058830/0812 →
Continuity (2)
Provisional Application
63143437
· Jan 29, 2021
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