Closed loop system for controlling insulin infusion
A closed loop infusion system controls the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The sensor signal is used to generate a controller input. The controller uses the controller input to generate commands to operate the delivery system. The delivery system infuses a liquid into the user at a rate dictated by the commands from the controller. Preferably, the sensor system monitors the glucose concentration in the body of the user, and the liquid infused by the delivery system into the body of the user includes insulin.
1. A method of infusing insulin into a body of a user, the method comprising:
obtaining a blood glucose concentration of the user;
generating a controller input based on the blood glucose concentration; and
generating infusion commands by a proportional plus, integral plus, derivative (PID) controller from the controller input using at least one preset controller gain;
wherein the at least one preset controller gain includes at least one tuning parameter that further modifies the infusion commands generated by the PID controller to create an insulin concentration profile that more closely resembles the insulin concentration profile that would be generated by the release of insulin by beta cells in an individual with a healthy normally functioning pancreas; and
wherein the at least one tuning parameter is an integrator leak.
2. A method of infusing insulin into a body of a user, the method comprising:
obtaining a blood glucose concentration of the user;
generating a controller input based on the blood glucose concentration; and
generating infusion commands by a proportional plus, integral plus, derivative (PID) controller from the controller input using at least one preset controller gain;
wherein the at least one preset controller gain includes at least one tuning parameter that further modifies the infusion commands generated by the PID controller to create an insulin concentration profile that more closely resembles the insulin concentration profile that would be generated by the release of insulin by beta cells in an individual with a healthy normally functioning pancreas; and
wherein the at least one tuning parameter is a lead/lag compensator.
3. A method of infUsing insulin into a body of a user, the method comprising:
obtaining a blood glucose concentration of the user;
generating a controller input based on the blood glucose concentration; and
generating infusion commands by a proportional plus, integral plus, derivative (PID) controller from the controller input using at least one preset controller gain;
wherein the at least one preset controller gain includes at least one tuning parameter that further modifies the infUsion commands generated by the PID controller to create an insulin concentration profile that more closely resembles the insulin concentration profile that would be generated by the release of insulin by beta cells in an individual with a healthy normally functioning pancreas; and
wherein the at least one tuning parameter is an integrator clip.