METHOD OF INITIATING AND ESCALATING SOTALOL HYDROCHLORIDE DOSING
The present invention provides novel methods of initiating and escalating sotalol hydrochloride in patients in need thereof.
1 - 20 . (canceled)
21 . A method of escalating oral sotalol hydrochloride therapy, comprising:
identifying a subject:
(i) as having a creatinine clearance within a range of 10-90 mL/min;
(ii) as having had symptomatic atrial fibrillation or atrial flutter, wherein the subject is currently in sinus rhythm; and
(iii) as having received a prior oral dose of 120 mg of sotalol hydrochloride;
administering an intravenous (IV) dose of 105 mg of sotalol hydrochloride to the subject over a period of 1 hour to escalate the subject from the prior oral dose of 120 mg to a higher target oral dose of 160 mg.
22 . The method of claim 21 , wherein:
the subject is identified as non-renally impaired and as having a creatinine clearance in the range of 60-90 mL/min; or
the subject is identified as renally impaired as indicated by having a creatinine clearance in the range of 10-30 mL/min.
23 . The method of claim 22 , further comprising after the administering of the IV dose, administering a 160 mg oral dose of sotalol hydrochloride to the non-renally impaired subject or to the renally impaired subject.
24 . The method of claim 23 , further comprising administering a second 160 mg oral dose of sotalol hydrochloride to the non-renally impaired subject or to the renally impaired subject.
25 . The method of claim 24 , wherein the subject is identified as renally impaired and as having a creatinine clearance in the range of 10-30 mL/min.
26 . The method of claim 24 , wherein the subject is identified as non-renally impaired and as having a creatinine clearance in the range of 60-90 mL/min.