IP Library Granted Patent US 11,951,099
Granted Patent B2
US 11,951,099 · App. 17/589,060 · Granted Apr 9, 2024

Methods for treating plasma cell neoplasm with human therapeutic agents

Inventors: Gene H. Zaid (Sterling, KS); Thomas W. Burgoyne (Lake Zurich, IL)
Assignee: Ankh Life Sciences Limited
A61K31/437A61K31/11A61K31/12A61K31/4375A61K45/06A61K47/10
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Quick Facts
Patent No.
US 11,951,099
App. No.
17/589,060
Granted
Apr 9, 2024
Kind
B2
Abstract

Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.

Claims (8)

1. A method of treating a patient suffering from plasma cell neoplasm, comprising the step of administering to the patient an anticancer composition comprising a combination of synergistically effective amounts of at least one curcumin component comprising curcumin, at least one harmine component comprising harmine, and at least one isovanillin component comprising isovanillin.

2. The method of claim 1 , wherein said curcumin is synthetically derived or derived from naturally occurring product(s) containing said curcumin which have been treated so that the curcumin is present at a level of at least about 25% by weight in the treated, curcumin-containing naturally occurring product(s), said harmine is synthetically derived or derived from naturally occurring product(s) containing said harmine which have been treated so that the harmine is present at a level of at least about 25% by weight in the treated, harmine-containing naturally occurring product(s), and said isovanillin is synthetically derived or derived from naturally occurring product(s) containing said isovanillin which have been treated so that the isovanillin is present at a level of at least about 25% by weight in the treated, isovanillin-containing naturally occurring product(s).

3. The method of claim 1 , wherein said curcumin, said harmine, and said isovanillin are each at least about 50% pure.

4. The method of claim 1 , wherein said isovanillin is present in an amount greater than the amounts of the harmine and the curcumin.

5. The method of claim 1 , wherein the ratio of said at least one curcumin component, said at least one harmine component, and said at least one isovanillin component is from about 0.1-5:0.1-5:0.1-25.

6. The method of claim 1 , wherein the at least one isovanillin component is present at a level of from about 25-85% by weight, the at least one harmine component is present at a level of from about 7-50% by weight, and the at least one curcumin component is present at a level of from about 5-40% by weight, based upon the total weight of the three components taken as 100% by weight.

7. The method of claim 1 , wherein said at least one curcumin component consists essentially of curcumin, said at least one harmine component consists essentially of harmine, and said at least one isovanillin component consists essentially of isovanillin.

8. The method of claim 1 , wherein said plasma cell neoplasm is multiple myeloma.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 31, 2022
From: IONS PHARMACEUTICAL S.A R.L.
To: ANKH LIFE SCIENCES LIMITED
Reel/Frame 058833/0590 →
Continuity (14)
Continuation 17000164 · Aug 21, 2020
Continuation 16724979 · Dec 23, 2019
Continuation 16541665 · Aug 15, 2019
Continuation 16213774 · Dec 7, 2018
Continuation 15826101 · Nov 29, 2017
Continuation 15337987 · Oct 28, 2016
Continuation In Part PCTUS2015055968 · Oct 16, 2015
Continuation In Part 14721011 · May 26, 2015
Continuation PCTIB2016000723 · Apr 20, 2016
Continuation In Part 14721011 · May 26, 2015
Provisional Application 62184051 · Jun 24, 2015
Provisional Application 62161090 · May 13, 2015
Provisional Application 62066686 · Oct 21, 2014
Related Publication 20220152001A1 · May 19, 2022