IP Library Granted Patent US 12,381,014
Granted Patent B2
US 12,381,014 · App. 17/590,514 · Granted Aug 5, 2025

Method for enhancing an accuracy of a benign tumor development trend assessment system

Inventors: Cheng-Chia Lee (Taipei, TW); Huai-Che Yang (Taipei, TW); Wen-Yuh Chung (Taipei, TW); Chih-Chun Wu (Taipei, TW); Wan-Yuo Guo (Taipei, TW); Wei-Kai Lee (Taipei, TW); Tzu-Hsuan Huang (Taipei, TW); Chun-Yi Lin (Taipei, TW); Chia-Feng Lu (Taipei, TW); Yu-Te Wu (Taipei, TW)
Assignees: NATIONAL YANG MING CHIAO TUNG UNIVERSITY; TAIPEI VETERANS GENERAL HOSPITAL
G16H50/70G06T7/0014G16H30/20G16H50/20G16H80/00G06T2207/30096
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Quick Facts
Patent No.
US 12,381,014
App. No.
17/590,514
Granted
Aug 5, 2025
Kind
B2
Abstract

A method for enhancing an accuracy of a benign tumor development trend assessment system includes: a first processing procedure, an image captured before the treatment is inputted to and be processed by a server computing device of the benign tumor development trend assessment system to obtain a first processing result; a second processing procedure, the images captured before and in at least one period after the treatment are inputted to and processed by the server computing device to obtain a second processing result; a trend analyzing procedure, the trend analyzing module of the server computing device analyzes the first processing result, the second processing result and the trend pathways to obtain a tumor development trend result; and a storing procedure, the first processing result, the second processing result and the tumor development trend result are transformed to an individual trend pathway which is stored in the trend analyzing module.

Claims (17)

1. A method for enhancing an accuracy of a benign tumor development trend assessment system, the benign tumor development trend assessment system comprising an image outputting device and a server computing device, the server computing device comprising a trend analyzing module, the trend analyzing module storing a plurality of trend pathways, the trend pathways being obtained by the trend analyzing module through analyzing a plurality of reference images, and the image outputting device outputting an image captured from a benign tumor of a patient before a treatment and outputting an image captured from the benign tumor of the patient in at least one period after the treatment, the image comprising a T1-weighted (T1W) MRI image, T2-weighted (T2W) MRI image or T1-weighted gadolinium contrast enhanced T1W+C) MRI image, the method comprising:

a first processing procedure, the image captured before the treatment is inputted to the server computing device and is processed by the server computing device to obtain a first processing result;

a second processing procedure, the image captured before the treatment and the image captured in at least one period after the treatment are inputted to the server computing device, and the images are processed by the server computing device to obtain a second processing result, wherein in the first processing procedure and the second processing procedure, a tumor region is automatically detected and delineated from the captured image by using U-Net neural network or 3D dual-pathway U-Net neural network, a grayscale feature is obtained from the captured image by using a histogram filter, a texture feature is obtained the captured image by using a gray-level run-length matrix (GLRLM) filter;

a trend analyzing procedure, the trend analyzing module analyzes the first processing result, the second processing result and the trend pathways through support vector machine (SVM), manual or gap analysis to obtain a tumor development trend result; and

a storing procedure, the first processing result, the second processing result and the tumor development trend result are transformed to an individual trend pathway, and the trend analyzing module further stores the individual trend pathway.

2. The method according to claim 1 , further comprising:

an adjusting procedure, the individual trend pathway is compared with the trend pathways to obtain an adjusting trend pathway.

3. The method according to claim 2 , wherein the image outputting device further outputs an image captured from the benign tumor of the patient in another period after the treatment.

4. The method according to claim 3 , further comprising:

a third processing procedure, the image captured in the another period after the treatment is inputted to the server computing device and the image is processed by the server computing device to obtain a third processing result; and

an accurate trend analyzing procedure, the trend analyzing module analyzes the third processing result, the individual trend pathway and/or the adjusting trend pathway to obtain an accurate tumor development trend result.

5. The method according to claim 4 , wherein the images of the benign tumor are automatically detected and delineated by the benign tumor development trend assessment system to obtain volumes of the images of the benign tumor and volume change ratios in the first processing procedure, the second processing procedure, or the third processing procedure, respectively.

6. The method according to claim 1 , wherein the images are captured from one patient.

7. The method according to claim 1 , wherein the images are 2D images and/or 3D images.

8. The method according to claim 1 , wherein the at least one period after the treatment is a plurality of periods, and at least one of the periods is partially overlapped with a recommend follow-up time point.

9. The method according to claim 8 , wherein the recommend follow-up time point is 6 months after the treatment, 12 months after the treatment, 18 months after the treatment, or 24 months after the treatment.

10. The method according to claim 8 , wherein a duration of the periods is 1 month, 2 months, 3 months, 4 months, 5 months, or 6 months.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 1, 2023
From: NATIONAL YANG MING CHIAO TUNG UNIVERSITY
To: NATIONAL YANG MING CHIAO TUNG UNIVERSITY; TAIPEI VETERANS GENERAL HOSPITAL
Reel/Frame 065733/0084 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 15, 2022
From: LEE, CHENG-CHIA; YANG, HUAI-CHE; CHUNG, WEN-YUH; WU, CHIH-CHUN; GUO, WAN-YUO; LEE, WEI-KAI; HUANG, TZU-HSUAN; LIN, CHUN-YI; LU, CHIA-FENG; WU, YU-TE
To: NATIONAL YANG MING CHIAO TUNG UNIVERSITY
Reel/Frame 059009/0632 →
Priority Claims (1)
TW 109106437 · Feb 27, 2020 · national
Continuity (2)
Continuation In Part 16939881 · Jul 27, 2020
Related Publication 20220157472A1 · May 19, 2022
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