Granted Patent B2

US 12,237,083 · App. 17/593,845 · Granted Feb 25, 2025

Inventors: Pavel Lazarev (Menlo Park, CA); Alexander Lazarev (Lake Forest, CA)

Assignee: Bragg Analytics, Inc.

G16H50/20A61B5/00A61B5/4312G01N23/20G01N23/201G01N33/4833G06F21/602G06N3/08G06Q20/085G06Q20/325G16H10/40G16H10/60G16H30/20G16H40/63G16H40/67G01N2223/0566G01N2223/6126

Abstract

Claims (25)

1. A system comprising:

(a) one or more diffraction apparatuses operatively coupled to a computer database over a network, wherein the one or more diffraction apparatuses are configured to collect sample data comprising diffraction pattern data for in vitro samples and transfer the sample data, or data derived therefrom, to the computer database over the network; and

(b) one or more computer processors operatively coupled to the one or more diffraction apparatuses, wherein the one or more computer processors are individually or collectively configured to:

(i) receive the sample data, or the data derived therefrom, from at least one of the one or more diffraction apparatuses;

(ii) transmit the sample data, or the data derived therefrom, from at least one of the one or more diffraction apparatuses to the computer database; and

(iii) process the sample data, or the data derived therefrom, for an individual in vitro sample using a data analytics algorithm that provides a computer-aided diagnostic indicator for the in vitro sample or for a subject from which the in vitro sample was derived, wherein the data analytics algorithm comprises a statistical analysis of diffraction pattern data or a function thereof.

2. The system of claim 1 , further comprising a user interface that allows an individual subject or a healthcare provider to upload the individual subject's sample data for an in vitro sample to the computer database in exchange for processing of the sample data to receive the computer-aided diagnostic indicator for the in vitro sample or for the individual subject.

3. The system of claim 1 , comprising two or more diffraction apparatuses located in two or more different geographic locations.

4. The system of claim 1 , wherein the one or more diffraction apparatuses comprise a data encryption device that includes a global positioning system (GPS) positioning sensor and generates encrypted sample data, and wherein when transferred to the computer database the encrypted sample data is used to track changes in location of the one or more diffraction apparatuses.

5. The system of claim 1 , wherein the one or more diffraction apparatuses are configured to perform small angle X-ray scattering (SAXS) measurements or wide angle X-ray scattering (WAXS) measurements.

6. The system of claim 1 , wherein the in vitro samples comprise a surgical sample, a resection sample, a pathology sample, a biopsy sample, or any combination thereof.

7. The system of claim 1 , wherein the sample data further comprises pathology lab image data, subject data, or any combination thereof.

8. The system of claim 7 , wherein the sample data comprises pathology lab image data, and wherein the pathology lab image data comprises micrographs of stained in vitro tissue specimens.

9. The system of claim 1 , wherein the sample data transferred to the computer database are depersonalized prior to the transfer.

10. The system of claim 9 , wherein a key for mapping the depersonalized sample data stored in the computer database to an individual subject is stored in a local institutional database or in the individual subject's personal files.

11. The system of claim 1 , wherein the statistical analysis comprises determination of a pair-wise distance distribution function, determination of a Patterson function, a calculation of a Porod invariant, a cluster analysis, a dispersion analysis, determination of one or more molecular structural periodicities, or any combination thereof.

12. The system of claim 11 , wherein the statistical analysis comprises a determination of a structural periodicity of collagen, a structural periodicity of one or more lipids, or a structural periodicity of a tissue.

13. The system of claim 1 , wherein the data analytics algorithm comprises a machine learning algorithm, wherein the machine learning algorithm comprises a supervised learning algorithm, an unsupervised learning algorithm, a semi-supervised learning algorithm, a reinforcement learning algorithm, a deep learning algorithm, or any combination thereof.

14. The system of claim 13 , wherein the machine learning algorithm is a deep learning algorithm, and wherein the deep learning algorithm is a convolutional neural network, a recurrent neural network, or a recurrent convolutional neural network.

15. The system of claim 13 , wherein the machine learning algorithm is trained using a training dataset comprising pathology lab image data, diffraction pattern data, subject data, or any combination thereof from one or more control samples.

16. The system of claim 15 , wherein the training dataset is updated as new sample data are uploaded to the computer database.

17. The system of claim 1 , wherein the sample data further comprises subject data comprising an individual subject's age, sex, ancestry data, genetic data, behavioral data, or any combination thereof, wherein the sample is from the individual subject.

18. The system of claim 1 , wherein the computer-aided diagnostic indicator for the in vitro sample comprises an indicator of a likelihood that the sample is positive or negative for a cancer.

19. The system of claim 18 , wherein the cancer comprises breast cancer, brain cancer, bone cancer, lung cancer, cervical cancer, bladder cancer, head and neck cancer, kidney cancer, intestinal cancer, liver cancer, ovarian cancer, pancreatic cancer, prostate cancer, skin cancer, throat cancer, oral cancer, vaginal cancer, or any combination thereof.

20. The system of claim 1 , wherein the system is used to monitor the efficacy of a cancer therapeutic treatment.

Assignments (1)

Continuity (2)

References Cited (50)