IP Library › Granted Patent US 12,473,308
Granted Patent B2
US 12,473,308 · App. 17/594,282 · Granted Nov 18, 2025

Luminescent silafluorene and germafluorene compounds

Inventors: Janet Braddock-Wilking (St. Louis, MO); Cynthia M. Dupureur (St. Louis, MO); Stephan Germann (St. Louis, MO); Helena Spikes (St. Louis, MO)
Assignee: The Curators of the University of Missouri
C07F7/0816C07F7/083C07F7/30C09K11/06C12Q1/02G01N1/30G01N21/6428C09K2211/1018G01N2001/302G01N2021/6439
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Quick Facts
Patent No.
US 12,473,308
App. No.
17/594,282
Granted
Nov 18, 2025
Kind
B2
Abstract

Described herein are luminescent sila- and germafluorenes. Also described herein are methods of making and using sila- and germafluorenes. The position and the type of substituent impact the absorption and emission properties in solution and in the solid-state and subsequently influence the role of sila- and germafluorenes as biosensors.

Claims (29)

1 . A method of measuring luminescence, the method comprising

introducing a composition comprising

a compound of Formula I,

wherein R 1 and R 2 are each independently selected from the group consisting of hydrogen, alkyl, and aryl; and

wherein R 3 , R 4 , R 5 , and R 6 are each independently selected from the group consisting of hydrogen, alkoxy, Y, and

 with the proviso that at least two of R 3 , R 4 , R 5 , and R 6 are selected from the group consisting of Y and

wherein Y is selected from the group consisting of aryl, substituted aryl, heteroaryl, and substituted heteroaryl;

a solvent; and

a detergent;

optically exciting the composition; and

measuring luminescence produced by the compound of Formula I.

2 . The method according to claim 1 , wherein the method step of introducing the composition comprises introducing the composition into a live cell.

3 . The method according to claim 1 , wherein the detergent is selected from the group consisting of anionic detergents, nonionic detergents, cationic detergents, zwitterionic detergents, and combinations thereof.

4 . The method according to claim 1 , wherein the method step of optically exciting the composition comprises irradiating the composition with a visible light source.

5 . The method according to claim 1 , wherein the solvent is a polar, water miscible solvent selected from the group consisting of acetonitrile, isopropyl alcohol, DMSO, and combinations thereof.

6 . A method of measuring luminescence, the method comprising

introducing a composition comprising

a compound of Formula IV,

wherein R 1 and R 2 are each independently selected from the group consisting of hydrogen, alkyl, and aryl; and

wherein R 3 , R 4 , R 5 , and R 6 are each independently selected from the group consisting of hydrogen, alkoxy, Y, and with the proviso that at least two of R 3 , R 4 , R 5 , and R 6 are selected from the group consisting of Y and ;

wherein Y is selected from the group consisting of

a solvent; and

a detergent;

optically exciting the composition; and

measuring luminescence produced by the compound of Formula IV.

7 . The method according to claim 6 , wherein the method step of introducing the composition comprises introducing the composition into a live cell.

8 . The method according to claim 6 , wherein the detergent is selected from the group consisting of anionic detergents, nonionic detergents, cationic detergents, zwitterionic detergents, and combinations thereof.

9 . The method according to claim 6 , wherein the method step of optically exciting the composition comprises irradiating the composition with a visible light source.

10 . The method according to claim 6 , wherein the solvent is a polar, water miscible solvent selected from the group consisting of acetonitrile, isopropyl alcohol, DMSO, and combinations thereof.

Assignments (2)
CONFIRMATORY LICENSE Recorded Apr 16, 2025
From: UNIVERSITY OF MISSOURI - ST. LOUIS
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 070865/0199 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 7, 2023
From: BRADDOCK-WILKING, JANET; DUPUREUR, CYNTHIA M.; GERMANN, STEPHAN; SPIKES, HELENA
To: THE CURATORS OF THE UNIVERSITY OF MISSOURI
Reel/Frame 063260/0780 →
Continuity (2)
Provisional Application 62831924 · Apr 10, 2019
Related Publication 20220162235A1 · May 26, 2022
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