HEMP EXTRACT FOR TREATMENT OF PAIN, CANCER AND EPILEPSY IN ANIMALS
The present disclosure relates to methods of treating epilepsy, cancer, and post-operative pain in veterinary subjects using pharmaceutical compositions and dosage forms comprising hemp extract.
1 . A pharmaceutical composition comprising hemp extract and a carrier, wherein the hemp extract comprises:
cannabidiol; and
cannabidiolic acid;
wherein the ratio of cannabidiol to cannabidiolic acid is about 0.6:1 to about 1:0.6, and
wherein the carrier comprises biopolymer NF-971P and/or lecithin.
2 . The pharmaceutical composition of claim 1 , wherein the hemp extract further comprises:
cannabigerolic acid;
Δ9-tetrahydrocannabinol; and
cannabichromene.
3 . The pharmaceutical composition of claim 1 , wherein the hemp extract further comprises four or more of:
α-pinene;
β-myrcene;
β-pinene;
δ-limonene;
linalool;
β-caryophyllene;
α-humulene;
nerolidol 2;
guaiol;
caryophyllene oxide; and
α-bisabolol.
4 . The pharmaceutical composition of claim 2 , wherein the concentration of Δ9-tetrahydrocannabinol is insufficient to produce a psychotropic effect.
5 .- 17 . (canceled)
18 . The pharmaceutical composition of claim 1 , wherein the carrier is selected from the group consisting of linseed oil, olive oil, fish oil, salmon oil, coconut oil, catnip oil, sesame oil, MCT oil, and grapeseed oil.
19 . (canceled)
20 . (canceled)
21 . The pharmaceutical composition of claim 1 , wherein the composition comprises lecithin.
22 .- 55 . (canceled)
56 . A dosage form comprising the pharmaceutical composition of claim 1 and one or more pharmaceutically acceptable additives, flavoring agents, surfactants, and adjuvants.
57 .- 68 . (canceled)
69 . The dosage form of claim 56 , wherein the composition is formulated as a chew for oral administration.
70 . The dosage form of claim 69 , where the chew is produced using cold extrusion.
71 . The dosage form of claim 70 , wherein the weight of the chew is about 0.5-10 g.
72 .- 129 . (canceled)
130 . A method of treating epilepsy in a veterinary subject in need thereof, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising hemp extract and a carrier, wherein the hemp extract comprises:
cannabidiol; and
cannabidiolic acid;
wherein the ratio of cannabidiol to cannabidiolic acid is about 0.6:1 to about 1:0.6.
131 . A method of treating cancer in a veterinary subject in need thereof, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising hemp extract and a carrier, wherein the hemp extract comprises:
cannabidiol; and
cannabidiolic acid;
wherein the ratio of cannabidiol to cannabidiolic acid is about 0.6:1 to about 1:0.6.
132 . A method of improving quality of life in a veterinary subject with cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising hemp extract and a carrier, wherein the hemp extract comprises:
cannabidiol; and
cannabidiolic acid;
wherein the ratio of cannabidiol to cannabidiolic acid is about 0.6:1 to about 1:0.6.
133 . The method of claim 130 , wherein the hemp extract further comprises:
cannabigerolic acid;
Δ9-tetrahydrocannabinol; and
cannabichromene.
134 . (canceled)
135 . The method of claim 133 , wherein the concentration of Δ9-tetrahydrocannabinol is insufficient to produce a psychotropic effect.
136 .- 149 . (canceled)
150 . The method of claim 130 , wherein the carrier is selected from the group consisting of linseed oil, olive oil, fish oil, salmon oil, coconut oil, catnip oil, sesame oil, MCT oil, and grapeseed oil.
151 .- 185 . (canceled)
186 . The method of claim 130 , comprising administering a dosage form comprising:
(a) the pharmaceutical composition, wherein the pharmaceutical composition further comprises:
(i) cannabigerolic acid,
(ii) Δ9-tetrahydrocannabinol,
(iii) cannabichromene; and
(b) one or more pharmaceutically acceptable additives, flavoring agents, surfactants, and adjuvants.
187 .- 221 . (canceled)
222 . The method of claim 186 , wherein the carrier is selected from the group consisting of linseed oil, olive oil, fish oil, salmon oil, coconut oil, catnip oil, sesame oil, MCT oil, and grapeseed oil.
223 .- 261 . (canceled)
262 . The method of claim 130 , wherein the composition comprises lecithin.
263 . The method of claim 222 , wherein the composition comprises lecithin.