Preparation of soluble compounds
Oxidized metal complexes are formed using methods which adjust the pH of solutions to obtain oxidized metal complexes having particular physicochemical properties. A method for preparing an oxidized metal complex includes providing a first solution comprising a highly oxidized metal and having a pH between 0 to 7; providing a second solution comprising one or more ligands or a ligand precursor and having a pH between 7 to 13 or greater; and combining the first solution and the second solution to form a third solution comprising the first oxidized metal complex. A method for preparing an oxidized metal complex includes providing a species solution comprising a first oxidized metal complex and having a pH of at least pH 11; and adjusting the pH of the species solution to form a second oxidized metal complex. Compositions and methods for preparing and using same are provided.
1. A method for preparing an oxidized metal complex comprising:
a) providing a species solution comprising a silver periodate complex and having a pH of at least pH 11; and
b) adjusting the pH of the species solution below pH 11 to form a silver diperiodate complex capable of providing enhanced antimicrobial activity compared to a silver periodate complex formed without performing the adjustment.
2. The method of claim 1 , further comprising adjusting one or more of pH, temperature, concentration, or combinations thereof.
3. The method of claim 1 , wherein the pH is adjusted between pH 2.0 to 11.
4. The method of claim 1 , further comprising adding an alkali metal, alkaline earth metal, or both to the species solution before or after pH adjustment, or after isolation of the silver diperiodate complex.
5. The method of claim 4 , wherein the alkali metal is selected from lithium, sodium, potassium, rubidium, cesium, or salts thereof selected from O 2− , Cl − , Br − , F − , I − , CrO 4 2− , CN − , PO 2 3− , S 2 O 5 2− , C 2 O 4 2− , IO 4 − , P 2 O 7 4− , SO 4 2 , B 4 O 7 2− , HCO 3 − , BF 4 − , CO 3 2− , NO 3 − , ClO 4 − , SO 4 2− , F − , Br − , C 3 H 3 O 2 − , NH 4 − , MnO 4 − , NO 2 − , BrO 3 − , IO 3 − , Cr 2 O 7 2− , OH − , ClO 3 − , HCO 2 − , or combinations thereof.
6. The method of claim 5 , wherein the oxidized metal complex is sodium silver diperiodate complex.
7. The method of claim 4 , wherein the alkaline earth metal is selected from beryllium, magnesium, calcium, strontium, barium, or salts thereof selected from O 2− , Cl − , Br − , F − , I − , CrO 4 2− , CN − , PO 2 3− , S 2 O 5 2− , C 2 O 4 2− , IO 4 − , P 2 O 7 4− , SO 4 2 , B 4 O 7 2− , HCO 3 − , BF 4 − , CO 3 2− , NO 3 − , ClO 4 − , SO 4 2− , F − , Br − , C 3 H 3 O 2 − , NH 4 − , MnO 4 − , NO 2 − , BrO 3 − , IO 3 − , Cr 2 O 7 2− , OH − , ClO 3 − , HCO 2 − , or combinations thereof.
8. The method of claim 7 , wherein the oxidized metal complex is selected from calcium silver diperiodate complex, magnesium silver diperiodate complex, or barium silver diperiodate complex.
9. The method of claim 4 , wherein the oxidized metal complex is a silver diperiodate complex comprising an alkali metal cation and an alkaline earth metal cation.
10. The method of claim 1 , wherein the pH is adjusted below pH 7.
11. The method of claim 5 , wherein the oxidized metal complex is potassium silver diperiodate complex.
12. The method of claim 11 , wherein the potassium silver diperiodate complex has the formula K 5-3 H 0-2 Ag(IO 5 OH) 2 .
13. The method of claim 1 , wherein the species solution comprising a silver periodate complex is formed by reacting silver oxynitrate with potassium periodate and potassium hydroxide, and the pH of the species solution is adjusted to below 11 to form a potassium silver diperiodate complex exhibiting enhanced stability.