Bioactive glass compositions
A silicate-based glass composition includes: 40-60 wt. % SiO 2 , 0-10 wt. % B 2 O 3 , 0.01-10 wt. % P 2 O 5 , 0-10 wt. % Al 2 O 3 , 0-5 wt. % Li 2 O, 10-30 wt. % Na 2 O, 0.01-15 wt. % K 2 O, 0.01-5 wt. % MgO, 15-30 wt. % CaO, 15-35 wt. % MO, and 15-30 wt. % R 2 O, such that MO is the sum of MgO, CaO, SrO, BeO, and BaO, and R 2 O is the sum of Na 2 O, K 2 O, Li 2 O, Rb 2 O, and Cs 2 O.
1. A silicate-based glass composition, comprising:
47.7-50.3 wt. % SiO 2 ,
0-10 wt. % B 2 O 3 ,
4.7-5.3 wt. % P 2 O 5 ,
0-10 wt. % Al 2 O 3 ,
0-5 wt. % Li 2 O,
12.2-18.3 wt. % Na 2 O,
4-8 wt. % K 2 O,
1.7-3.3 wt. % MgO,
21.5-23 wt. % CaO,
15-35 wt. % MO, and
15-30 wt. % R 2 O,
wherein MO is the sum of MgO, CaO, SrO, BeO, and BaO, and
wherein R 2 O is the sum of Na 2 O, K 2 O, Li 2 O, Rb 2 O, and Cs 2 O; and
wherein a difference between a glass transition temperature (T g ) of the glass composition and an onset of crystallization temperature (T c,o ) is at least 200° C.
2. The glass composition of claim 1 , further comprising:
hydroxyapatite formation within seven days of immersion in simulated body fluid (SBF).
3. The glass composition of claim 2 , wherein the hydroxyapatite formation comprises: granular spherical crystals having at least one size dimension in a range of 0.1-10 μm.
4. The glass composition of claim 1 , having a melting temperature of below 1200° C.
5. The glass composition of claim 1 , being a particle, bead, particulate, short fiber, long fiber, woolen mesh, combination thereof.
6. The glass composition of claim 5 , having at least one size dimension in a range of 1-100 μm.
7. The glass composition of claim 5 , having at least one size dimension in a range of 1-10 μm.
8. The glass composition of claim 1 , essentially free of at least one of B 2 O 3 , Al 2 O 3 , and Li 2 O.
9. The glass composition of claim 1 , comprising 1 wt. % or less of at least one of B 2 O 3 , Al 2 O 3 , and Li 2 O.
10. A matrix comprising the glass composition of claim 1 , wherein:
the matrix includes at least one of: a toothpaste, mouthwash, rinse, spray, ointment, salve, cream, bandage, polymer film, oral formulation, pill, capsule, or transdermal formulation.
11. The matrix of claim 10 , wherein the glass composition is attached to the matrix or mixed therein.
12. An antibacterial composition comprising: a silicate-based glass composition; and
a culture medium having a pH in a range of 7 to 11;
wherein the silicate-based glass composition comprises:
47.7-50.3 wt. % SiO 2 ,
0-10 wt. % B 2 O 3 ,
4.7-5.3 wt. % P 2 O 5 ,
0-10 wt. % Al 2 O 3 ,
0-5 wt. % Li 2 O,
12.2-18.3 wt. % Na 2 O,
4-8 wt. % K 2 O,
1.7-3.3 wt. % MgO,
21.5-23 wt. % CaO,
15-35 wt. % MO, and
15-30 wt. % R 2 O,
wherein MO is the sum of MgO, CaO, SrO, BeO, and BaO, and
wherein R 2 O is the sum of Na 2 O, K 2 O, Li 2 O, Rb 2 O, and Cs 2 O; and
wherein the antimicrobial composition is colorless or essentially colorless; and
wherein a difference between a glass transition temperature (T g ) of the glass composition and an onset of crystallization temperature (T c,o ) is at least 200° C.
13. The antibacterial composition of claim 12 , wherein the silicate-based glass composition further comprises:
hydroxyapatite formation within seven days of immersion in simulated body fluid (SBF).
14. The antimicrobial composition of claim 13 , wherein the hydroxyapatite formation comprises: granular spherical crystals having at least one size dimension in a range of 0.1-10 μm.
15. The antimicrobial composition of claim 12 , wherein the silicate-based glass composition comprises a melting temperature of below 1200° C.
16. The antimicrobial composition of claim 12 , wherein the silicate-based glass composition is essentially free of at least one of B 2 O 3 , Al 2 O 3 , and Li 2 O.