Natriuretic peptide receptor a agonists useful for the treatment of cardiometabolic diseases, kidney disease and diabetes

1. A compound of the formula I, or a pharmaceutically acceptable salt thereof:

wherein

X is N or CH;

R 1 is selected from phenyl, pyridyl, thiazolyl, imidazolyl, pyrazinyl, and oxadiazolyl, wherein R 1 is substituted by 0, 1, 2, or 3, R 5 ;

R 2 is independently selected from:

arylC 0-10 alkyl,

C 3-12 cycloalkylC 0-10 alkyl,

heteroarylC 0-10 alkyl,

heterocyclylC 0-10 alkyl,

C 1-10 alkylaminoC 0-10 alkyl,

heteroarylC 0-10 alkylaminoC 0-10 alkyl,

heterocyclylC 0-10 alkylaminoC 0-10 alkyl,

C 1-10 heteroalkyl aminoC 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

aryl C 0-10 alkylaminoC 0-10 alkyl,

amino, and

(C 1-10 alkyl) 1-2 amino;

wherein R 2 is each substituted with 0, 1, 2, 3, or 4 R 4 substituents;

each R 3 is independently selected from hydrogen, halogen, C 1-6 alkyl, and C 3-12 cycloalkyl C 0-10 alkyl, and heterocyclylC 0-10 alkyl, wherein R 3 is substituted by 0, 1, 2 or 3 groups independently selected from C 1-6 alkyl, C 1-6 haloalkyl, and halogen;

each R 4 is independently selected from:

halogen,

C 1-10 alkyl,

C 1-10 heteroalkyl,

aryl C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl,

heteroaryl C 0-10 alkyl,

heterocyclylC 0-10 alkyl,

amino C 0-10 alkyl,

((C 1-10 )alkyl) 1-2 amino,

—CO 2 (C 1-10 alkyl),

—(C 0-10 alkyl) CO 2 H,

OXO,

hydroxy,

—(C 1-10 alkyl)OH,

C 1-10 alkoxy,

cyano, and

C 1-6 haloalkyl;

wherein R 4 is each substituted with 0, 1, 2, 3, or 4 R 8 substituents and each R 8 is independently selected from: C 1-10 alkyl, —CO 2 (C 1-10 alkyl), —(C 0-10 alkyl) CO 2 H, C 1-10 alkoxy, halogen, C 1-6 haloalkyl, cyano, oxo, hydroxy, and amino;

R 5 is independently selected from:

halogen,

C 1-10 alkyl,

aryl C 0-10 alkyl,

C 3-12 cycloalkylC 0-10 alkyl,

heteroaryl C 0-10 alkyl,

heterocyclyl C 0-10 alkyl,

C 1-10 alkylcarbonylC 0-10 alkyl,

C 1-10 heteroalkylcarbonylC 0-10 alkyl,

arylcarbonylC 0-10 alkyl,

(C 3-12 )cycloalkyl carbonylC 0-10 alkyl,

heteroarylcarbonylC 0-10 alkyl,

heterocyclylcarbonylC 0-10 alkyl,

((C 0-10 )alkyl) 1-2 aminocarbonyl,

C 1-10 alkoxy,

aryl C 0-10 alkyloxy,

C 3-12 cycloalkyloxy,

heteroaryl C 0-10 alkyloxy,

heterocyclyl C 0-10 alkyloxy,

(C 0-10 )alkylaminocarbonyl,

(C 1-10 )heteroalkylaminocarbonyl,

aryl(C 0-10 )alkylaminocarbonyl,

(C 3-12 )cycloalkyl(C 0-10 )alkylaminocarbonyl,

heteroaryl(C 0-10 )alkylaminocarbonyl,

heterocyclyl(C 0-10 )alkylaminocarbonyl,

C 0-10 alkylcarbonylaminoC 0-10 alkyl,

C 1-10 heteroalkylcarbonylaminoC 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkylcarbonylaminoC 0-10 alkyl,

aryl C 0-10 alkylcarbonylaminoC 0-10 alkyl,

heteroaryl C 0-10 alkylcarbonylaminoC 0-10 alkyl,

heterocyclyl C 0-10 alkylcarbonylamino,

—SO 2 N(C 1-6 alkyl) 0-2 ,

C 0-6 alkylS(O) 1-2 amino,

—SO 2 CF 3 ,

—SO 2 CF 2 H,

amino,

(C 0-10 alkyl) 1-2 amino,

hydroxy,

(C 1-10 alkyl)OH,

cyano,

C 1-6 haloalkyl,

—CO 2 (C 1-10 alkyl),

(C 0-10 alkyl) CO 2 H,

OXO,

C 1-10 alkylS(O) 1-2 ,

C 1-10 heteroalkyl S(O) 1-2 ,

(C 3-12 )cycloalkylS(O) 1-2 ,

heterocyclyl S(O) 1-2 ,

heteroarylS(O) 1-2 , and

arylS(O) 1-2 ;

wherein R 5 is each substituted with 0, 1, 2, 3, or 4 R 6 ;

each R 6 is independently selected from:

halogen,

C 1-10 alkyl,

C 1-6 haloalkyl,

C 1-10 heteroalkyl,

aryl C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl,

heteroaryl C 0-10 alkyl,

heterocyclyl C 0-10 alkyl,

amino C 0-10 alkyl,

((C 1-10 )alkyl) 1-2 amino,

—CO 2 (C 1-10 alkyl),

—(C 0-10 alkyl) CO 2 H,

OXO,

hydroxy,

—(C 1-10 alkyl)OH,

C 1-10 alkoxy,

cyano, and

aminocarbonyl; and

wherein R 6 is each substituted with 0, 1, 2, or 3, R 7 substituents and each R 7 is independently selected from: C 1-4 alkyl, hydroxy, —CO 2 (C 1-6 alkyl), —(C 0-6 alkyl) CO 2 H, C 1-6 alkoxy, halogen, C 1-6 haloalkyl, cyano, and amino.

2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein X is N.

3. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein X is CH.

4. The compound of claim 3 or a pharmaceutically acceptable salt thereof, wherein R 1 is phenyl or pyridyl, wherein R 1 is substituted by 0, 1, 2 or 3 R 5 .

5. The compound of claim 4 or a pharmaceutically acceptable salt thereof, wherein R 5 is independently selected from: halogen, C 1-10 alkyl, aryl C 0-10 alkyl, C 3-12 cycloalkylC 0 -10 alkyl, heteroaryl C 0-10 alkyl, heterocyclyl C 0-10 alkyl, C 1-10 alkylcarbonylC 0-10 alkyl, C 1-10 heteroalkylcarbonylC 0-10 alkyl, arylcarbonylC 0-10 alkyl, (C 3-12 )cycloalkyl carbonylC 0-10 alkyl, heteroarylcarbonylC 0-10 alkyl, heterocyclylcarbonylC 0-10 alkyl, ((C 0-10 )alkyl) 1-2 aminocarbonyl, C 1-10 alkoxy, aryl C 0-10 alkyloxy, C 3-12 cycloalkyloxy, heteroaryl C 0-10 alkyloxy, heterocyclyl C 0-10 alkyloxy, (C 0-10 )alkylaminocarbonyl, (C 1-10 )heteroalkylaminocarbonyl, aryl(C 0-10 )alkylaminocarbonyl, (C 3 -12)cycloalkyl(C 0-10 )alkylaminocarbonyl, heteroaryl(C 0-10 )alkylaminocarbonyl, heterocyclyl(C 0-10 )alkylaminocarbonyl, C 0-10 alkylcarbonylaminoC 0-10 alkyl, heterocyclyl C 0-10 alkylcarbonylamino, —SO 2 N(C 1-6 alkyl) 0-2 , C 0-6 alkylS(O) 1-2 amino, amino, (C 0-10 alkyl) 1-2 amino, hydroxy, —(C 1-10 alkyl)OH, cyano, C 1-6 haloalkyl, —(C 0-10 alkyl) CO 2 H, oxo, C 1-10 alkylS(O) 1-2 , wherein R 5 is each substituted with 0, 1, 2, 3, or 4 R 6 .

6. The compound of claim 5 or a pharmaceutically acceptable salt thereof, wherein R 5 is independently selected from: pyridyl, pyrimidinyl, furyl, pyrazolyl, thiophenyl, methylsulfonylamino, pyrrolidinylcarbamoyl, imidazolyl, triazoylyl, oxazolidinyl, azetidinylcarbamoyl, (pyrrolidinylmethyl) carbamoyl, diazaspiro[3.3]heptane-carbonyl, ethylcarbamoyl, azetidinylcarbonyl, aminocarbonyl, morpholinylcarbonyl, piperazinylcarbonyl, methylcarbamoyl, 1-oxa-3,8-diazaspiro[4.5]decanyl, imidazolidinyl, pyrrolidinylcarbonylamino, ethylcarbonylamino, thiophenyl, phenyl, 1-oxa-4,7-diazaspiro[4,4]nonane-carbonyl, 2,8-diazaspiro[3.5]nonane-carbonyl, piperidylcarbamoyl, octahydropyrrolo[2,3-b]pyrrole-carbonyl, (morpholinoethyl) carbamoyl, morpholinocarbonyl, octahydropyrrolo[3,4-b][1,4]oxazine-carbonyl, pyridazinyl, 1,2-dihydropyridazinyl, 1,2,4-thiadiazolyl, 1,2,4-triazolyl, isoxazolyl, tetrazolyl, 1,2,3,4-tetrahydropyrimidinyl, 1,2,4-thiadiazolyl, pyrrolidinyl, pyrazolyloxy, ethoxy, phenoxy, 1,2-dihydropyridinyl, —NHS(O)2H, 1,3,4-oxathiazinanyl, halogen, and pyridazinyl, wherein R 5 is each substituted with 0, 1, 2, 3, or 4 R 6 .

7. The compound of claim 6 or a pharmaceutically acceptable salt thereof, wherein each R 6 is independently selected from hydroxy, oxo, methyl, carboxy, fluoro, chloro, amino, hydroxyethyl, pyrrolidinylmethyl, 2,2,2-trifluoroethyl, benzyl, cyclopropyl, ethoxy, morpholinyl, cyano, trifluoromethyl, methylcarboxy, aminocarbonyl (carbamoyl), dimethylamino, dimethylsulfamoyl, ethylsulfonyl, and methoxy, wherein R 6 is each substituted with 0,1, or 2, R 7 substituents, and the other groups are provided in the general formula above, or as in the first through sixth embodiments.

8. The compound of claim 7 or a pharmaceutically acceptable salt thereof, wherein each R 2 is independently selected from: piperidinyl, dimethylamino, tetrahydropyranylamino, 5-azaspiro[2.5]octanyl, cyclobutylamino, 2,7-diazaspiro[4.5]decanyl, azetidinyl, oxetanylamino, cyclohexylamino, cyclopentylamino, azabicyclo[3.1.0]hexanyl, pyrrolidinyl, diethylamino, tetrazolyl, 1-oxa-3-azaspiro[4.5]decanyl, methylamino, ethylamino, 2-oxa-5-azabicyclo[2.2.1]heptanyl, piperidylamino, pyrrolidinylamino, piperazinyl, (tetrahydrofuranyl)amino, morpholinyl, N-methylethylamino, octahydro-2H-pyrano[3,2-c]pyridine, oxazepanyl, 1,2,3,6-tetrahydropyridyl, cyclopropylamino, isobutylamino, (pyrazolylmethyl)amino, and diazepanyl; wherein R 2 is each substituted with 0, 1, 2, 3, or 4 R 4 substituents.

9. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein R 4 is independently selected from: halogen, C 1-10 alkyl, aryl C 0-10 alkyl, C 3-12 cycloalkyl C 0-10 alkyl, heteroaryl C 0-10 alkyl, amino C 0-10 alkyl, ((C 1-10 )alkyl) 1-2 amino, —CO 2 (C 1-10 alkyl), —(C 0-10 alkyl) CO 2 H, oxo, hydroxy, —(C 1-10 alkyl)OH, C 1-10 alkoxy, cyano, and C 1-6 haloalkyl; wherein R 4 is each substituted with 0, 1, 2, 3, or 4 R 8 .

10. The compound of claim 9 or a pharmaceutically acceptable salt thereof, wherein each R 8 is independently selected from methyl, ethyl, propyl, methoxy, ethoxy, amino or carboxy.

11. The compound of claim 10 or a pharmaceutically acceptable salt thereof, wherein each R 3 is independently selected from hydrogen, halogen, C 1-6 alkyl, and C 3-12 cycloalkyl C 0-10 alkyl, wherein R 3 is substituted by 0, 1, 2 or 3 groups independently selected from C 1-6 alkyl, C 1-6 haloalkyl, and halogen.

12. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, selected from

ammonium;5-[4-[(1R)-3-(1-piperidyl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]yridine-2-olate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(2-oxo-1H-pyrimidin-5-yl)phenyl]-3-(1-piperidyl)propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(3-furyl)phenyl]-3-(1-piperidyl)propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(3-furyl)phenyl]-3-(1-piperidyl)propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(2-methylpyrazol-3-yl)phenyl]-3-(1-piperidyl)propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-3-(1-piperidyl)-1-[4-(1H-pyrazol-4-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

ammonium;4-[4-[(1R)-3-(1-piperidyl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]thiophene-2-carboxylate;

(6S)-6-tert-butyl-N-[(1R)-3-(1-piperidyl)-1-(4-pyrimidin-5-ylphenyl)propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

ammonium; methylsulfonyl-[3-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium methylsulfonyl-[3-[(1R)-3-(dimethylamino)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium methylsulfonyl-[3-[(1R)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]-3-(tetrahydropyran-4-ylamino) propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-3-(1-piperidyl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium methylsulfonyl-[3-[(1R)-3-(3-hydroxy-1-piperidyl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium methylsulfonyl-[3-[(1R)-3-(5-azaspiro[2.5]octan-5-yl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-3-(4-fluoro-1-piperidyl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[[(1R)-3-[1-(hydroxymethyl)cyclobutyl]amino]-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-3-(3-hydroxy-3-methyl-azetidin-1-yl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-3-(4-imidazol-1-yl-1-piperidyl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-3-[3-(3-pyridyl)-1-piperidyl]-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-3-(1-oxo-2,9-diazaspiro[4.5]decan-9-yl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-3-(azetidin-1-yl)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-3-(oxetan-3-ylamino)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-3-[3-(2-pyridyl) azetidin-1-yl]-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-3-[4-(2-pyridyl)-1-piperidyl]-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]phenyl]azanide;

ammonium; methylsulfonyl-[3-[(1R)-1-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]-3-[[(1S,2R)-3,3-difluoro-2-hydroxy-cyclohexyl]amino]propyl]phenyl]azanide;

dimethyl-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

[(1S,2R,3S,4S)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-3-[6-(hydroxymethyl)-3-azoniabicyclo[3.1.0]hexan-3-yl]-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

dimethyl-[1-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]-4-piperidyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[4-(1,2,4-triazol-4-yl)piperidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-3-[2-(hydroxymethyl)piperidin-1-ium-1-yl]-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[(2R,3S)-3-hydroxy-2-(hydroxymethyl)piperidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-piperidin-1-ium-1-yl-propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-pyrrolidin-1-ium-1-yl-propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-3-[bis(2-hydroxyethyl)amino]-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[4-(tetrazol-2-yl) piperidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]-tetrahydropyran-4-yl-ammonium;formate;

[(3R,4S)-3,4-dihydroxycyclopentyl]-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

[(3R,4S)-3,4-dihydroxycyclopentyl]-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(2-oxo-1-oxa-3-aza-8-azoniaspiro[4.5]decan-8-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(3-hydroxypyrrolidin-1-ium-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(methylamino)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

1-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]piperidin-1-ium-4-carboxylic acid;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(4-hydroxy-4-methyl-piperidin-1-ium-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

[3-methyl-1-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]azetidin-3-yl]methylammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(5-azoniaspiro[2.5]octan-5-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(3-hydroxyazetidin-1-ium-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

2-hydroxyethyl-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

cyclopentyl-methyl-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[(3R,4R)-3,4-dihydroxypyrrolidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

cyclopentyl-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(2-oxa-5-azoniabicyclo[2.2.1]heptan-5-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(2-oxo-4-piperidyl)-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(3-hydroxypiperidin-1-ium-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

1-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]piperidin-1-ium-3-carboxylic acid;formate;

(5-oxopyrrolidin-3-yl)-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[3-(2H-tetrazol-5-yl)pyrrolidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(4-fluoropiperidin-1-ium-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-3-[4-(difluoromethyl)piperidin-1-ium-1-yl]-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[(3S,4R)-3,4-dihydroxypyrrolidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(4-methoxypiperidin-1-ium-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(1-methylazetidin-3-yl)-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(3-hydroxy-3-methyl-azetidin-1-ium-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-3-[4-(2-methoxyethyl)piperazin-1-yl]-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(2-oxopyrrolidin-3-yl)-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-3-(4-cyanopiperidin-1-ium-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

[(3S,4R)-4-hydroxytetrahydrofuran-3-yl]-[(3R)-3-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[(3S,4S)-3-(dimethylamino)-4-hydroxy-pyrrolidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-[(2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;formate;

(6S)-6-tert-butyl-N-[(1R)-3-morpholino-1-[4-[[(3S,4S)-4-hydroxypyrrolidin-3-yl]carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-[3-(hydroxymethyl)pyrrolidin-1-yl]-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]-3-(tetrahydropyran-4-ylamino) propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(3,3-dimethylazetidin-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(3-hydroxypyrrolidin-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[4-(6-oxo-1H-pyridin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;formate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[4-(1H-pyrazol-4-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;formate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[4-(2-methylpyrazol-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;formate;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(5-fluoro-6-hydroxy-3-pyridyl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-(4-imidazol-1-ylphenyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[4-(1,2,4-triazol-1-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[4-(2-oxooxazolidin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-[(1-methylazetidin-3-yl) carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-[[(3S)-1-methylpyrrolidin-3-yl]carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-[(1-methylpyrrolidin-3-yl)methylcarbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-[[(3S)-pyrrolidin-3-yl]carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-[[(3R,4R)-4-hydroxypyrrolidin-3-yl]carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(2,6-diazaspiro[3.3]heptane-2-carbonyl)phenyl]-3-(dimethylamino) propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(2-aminoethylcarbamoyl)phenyl]-3-(dimethylamino) propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-(3-hydroxy-3-methyl-azetidine-1-carbonyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(3-aminoazetidine-1-carbonyl)phenyl]-3-(dimethylamino) propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-(2-hydroxyethylcarbamoyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-(morpholine-4-carbonyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-(piperazine-1-carbonyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-(methylcarbamoyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-(3-carbamoylphenyl)-3-(dimethylamino) propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(dimethylamino)-1-[3-[[1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

2-[1-[(3R)-3-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-4-piperidyl]acetic acid;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-[4-(2-hydroxyethyl)-1-piperidyl]-1-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[4-(1H-tetrazol-5-yl)-1-piperidyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-[4-(hydroxymethyl)-1-piperidyl]-1-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

4-[1-[(3R)-3-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-4-piperidyl]benzoic acid;2,2,2-trifluoroacetate;

2-[(2S)-1-[(3R)-3-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]pyrrolidin-2-yl]acetic acid;2,2,2-trifluoroacetate;

3-[1-[(3R)-3-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-4-piperidyl]benzoic acid;2,2,2-trifluoroacetate;

3-[(3R)-3-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-methoxy-1-piperidyl)-1-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

methyl 2-[1-[(3R)-3-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-4-piperidyl]acetate;2,2,2-trifluoroacetate;

3-[methyl-[(3R)-3-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]amino]propanoic acid;2,2,2-trifluoroacetate;

(3R)-1-[(3R)-3-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetate;

(3S)-1-[(3R)-3-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetate;

methyl 1-[(3R)-3-[3-[(1-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]piperidine-4-carboxylate;2,2,2-trifluoroacetate;

carboxymethyl-[(3R)-3-[3-[(1-methylazetidin-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]ammonium;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-(2-oxo-1-oxa-3-aza-8-azoniaspiro[4.5]decan-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[3-(2-oxoimidazolidin-1-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-(pyrrolidin-1-ium-3-carbonylamino)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2 trifluoroacetate;

[3-oxo-3-[3-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]anilino]propyl]ammonium;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[3-(2-oxooxazolidin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

1-[(3R)-3-[3-[(1-methylpyrrolidin-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]piperidine-4-carboxylic acid;

1-[(3R)-3-[3-(azetidin-1-ium-3-ylcarbamoyl)phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]piperidine-4-carboxylic acid;2,2,2-trifluoroacetate;

1-[(3R)-3-[3-[(1-benzylazetidin-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]piperidin-1-ium-4-carboxylic acid;2,2,2-trifluoroacetate;

1-[(3R)-3-[3-[(1-cyclopropylpyrrolidin-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]piperidin-1-ium-4-carboxylic acid;2,2,2-trifluoroacetate;

1-[(3R)-3-[3-[(3-methylazetidin-1-ium-3-yl) carbamoyl]phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]piperidine-4-carboxylic acid;2,2,2-trifluoroacetate;

4-[4-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]phenyl]thiophene-2-carboxylic acid;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[4-(2-oxo-1H-pyrimidin-5-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[4-[6-(2-fluoroethoxy)-3-pyridyl]phenyl]-3-(4-hydroxypiperidin-1-ium-1-yl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(4-hydroxyphenyl)phenyl]-3-(4-hydroxypiperidin-1-ium-1-yl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[[(3R)-pyrrolidin-3-yl]carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(2,8-diazaspiro[3.5]nonane-2-carbonyl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[3-(pyrrolidin-1-ylmethyl) azetidine-1-carbonyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-(4-piperidylcarbamoyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[[(3R)-1-methylpyrrolidin-3-yl]carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[[(3R,4R)-4-hydroxypyrrolidin-3-yl]carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(azetidin-3-ylcarbamoyl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[[(3S,4S)-4-hydroxypyrrolidin-3-yl]carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[[(3S)-1-methylpyrrolidin-3-yl]carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-[(2,2-dimethylpyrrolidin-3-yl) carbamoyl]phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[(1-methyl-3-piperidyl) carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[(1-methyl-4-piperidyl) carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[(1-methylpyrrolidin-3-yl)methylcarbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-(3-piperidylcarbamoyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-(5-methyl-6-oxo-7-oxa-2,5-diazaspiro[3.4]octane-2-carbonyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(3-hydroxy-3-methyl-azetidine-1-carbonyl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(2,3,3a,5,6,6a-hexahydro-1H-pyrrolo[3,2-b]pyrrole-4-carbonyl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(3-aminoazetidine-1-carbonyl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-[3-(dimethylamino) azetidine-1-carbonyl]phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[(1-methyl-5-oxo-pyrrolidin-3-yl) carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-(2-morpholinoethylcarbamoyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(2-hydroxyethylcarbamoyl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-(pyrrolidin-3-ylmethylcarbamoyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[3-hydroxy-3-(trifluoromethyl) azetidine-1-carbonyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[(2-oxopyrrolidin-3-yl) carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[(5-oxopyrrolidin-3-yl) carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(3-hydroxyazetidine-1-carbonyl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-(3-morpholinoazetidine-1-carbonyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[(1-methyl-6-oxo-3-piperidyl) carbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[(1-methyl-5-oxo-pyrrolidin-3-yl)methylcarbamoyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

methyl 4-[3-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]benzoyl]morpholine-2-carboxylate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[3-[(4aR,7aS)-3,4a,5,6,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazine-4-carbonyl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-(4-pyridazin-4-ylphenyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[4-(1-oxidopyridazin-1-ium-4-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[4-(6-hydroxy-3-pyridyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[4-(6-hydroxypyridazin-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(3-cyano-1H-pyrazol-4-yl)phenyl]-3-(4-hydroxypiperidin-1-ium-1-yl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[4-[3-(trifluoromethyl)-1H-pyrazol-4-yl]phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(2-amino-4-pyridyl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[4-(1,2,4-thiadiazol-5-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[4-(4-methyl-1,2,4-triazol-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[4-(3-methyl-1H-pyrazol-4-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(5-cyano-6-hydroxy-3-pyridyl)phenyl]-3-(4-hydroxypiperidin-1-ium-1-yl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[4-(5-methyl-1H-imidazol-4-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(3-amino-4-pyridyl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-(4-isoxazol-4-ylphenyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[4-(1-methyltetrazol-5-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(5-cyano-1H-imidazol-4-yl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[4-(3-methylimidazol-4-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-(4-isothiazol-4-ylphenyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(3-fluoro-5-hydroxy-2-pyridyl)phenyl]-3-(4-hydroxypiperidin-1-ium-1-yl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(2,4-dioxo-1H-pyrimidin-6-yl)phenyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[4-(1,2,5-thiadiazol-3-yl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[4-(3,5-difluoro-4-hydroxy-phenyl)phenyl]-3-(4-hydroxypiperidin-1-ium-1-yl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-(4-thiazol-5-ylphenyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[6-(2-oxooxazolidin-3-yl)-3-pyridyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

ammonium;3,5-dimethyl-1-[5-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-2-pyridyl]pyrazol-4-olate;

(7S)-7-tert-butyl-N-[(1R)-1-[6-(3-hydroxy-2-oxo-pyrrolidin-1-yl)-3-pyridyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[6-(4-hydroxy-1-piperidyl)-3-pyridyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[6-(3-hydroxypyrrolidin-1-yl)-3-pyridyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[6-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-3-pyridyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[6-(2-hydroxyethoxy)-3-pyridyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-1-[6-(2-amino-2-oxo-ethoxy)-3-pyridyl]-3-(4-hydroxy-1-piperidyl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

ammonium;4-[5-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-2-pyridyl]oxy]phenolate;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[6-(6-oxo-1H-pyridin-3-yl)-3-pyridyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-tert-butyl-N-[(1R)-3-(4-hydroxy-1-piperidyl)-1-[6-(1H-pyrazol-4-yl)-3-pyridyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

4-[5-[(1R)-3-(4-hydroxypiperidin-1-ium-1-yl)-1-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-2-pyridyl]thiophene-2-carboxylic acid;2,2,2-trifluoroacetate;

[1-[(3R)-3-[4-(5-fluoro-6-hydroxy-3-pyridyl)phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-4-piperidyl]ammonium;formate;

[4-hydroxy-1-[(3R)-3-[4-(5-fluoro-6-hydroxy-3-pyridyl)phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-4-piperidyl]methylammonium;formate;

(7S)-7-tert-butyl-N-[(1R)-3-[4-[(dimethylamino)methyl]-4-hydroxy-piperidin-1-ium-1-yl]-1-[4-(5-fluoro-6-hydroxy-3-pyridyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;formate;

(3R,4S)-3-fluoro-1-[(3R)-3-[4-(5-fluoro-6-hydroxy-3-pyridyl)phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]piperidin-1-ium-4-carboxylic acid;formate;

diethyl-[(3R)-3-[4-(5-fluoro-6-hydroxy-3-pyridyl)phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]ammonium;formate;

(3R,4R)-3-fluoro-1-[(3R)-3-[4-(5-fluoro-6-hydroxy-3-pyridyl)phenyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]piperidin-1-ium-4-carboxylic acid;formate;

(7S)-7-tert-butyl-N-[(1R)-3-(3,4,4a,5,6,7,8,8a-octahydro-2H-pyrano[3,2-c]pyridin-6-ium-6-yl)-1-[4-(5-fluoro-6-hydroxy-3-pyridyl)phenyl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;formate;

(7S)-7-tert-butyl-N-[(1R)-1-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-(1,4-oxazepan-4-ium-4-yl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

2-hydroxyethyl-methyl-[(3R)-3-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]ammonium;2,2,2-trifluoroacetate;

[(3R)-3-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]-bis(trideuteriomethyl) ammonium;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-(1,2,3,6-tetrahydropyridin-1-ium-1-yl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(1-hydroxycyclopropyl)methyl-methyl-[(3R)-3-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]ammonium;2,2,2-trifluoroacetate;

2-methoxyethyl-methyl-[(3R)-3-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]ammonium;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-[(3R)-3-hydroxypyrrolidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

isobutyl-methyl-[(3R)-3-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]ammonium;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-[(2S)-2-(hydroxymethyl) azetidin-1-ium-1-yl]propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

methyl-(1H-pyrazol-5-ylmethyl)-[(3R)-3-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-[[(7S)-7-tert-butyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carbonyl]amino]propyl]ammonium;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[6-(dimethylsulfamoylamino)-3-pyridyl]-3-(5-oxo-1,4-diazepan-1-ium-1-yl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;2,2,2-trifluoroacetate;

(7S)-7-tert-butyl-N-[(1R)-1-[3-(dimethylsulfamoylamino)phenyl]-3-(4-hydroxypiperidin-1-ium-1-yl)propyl]-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

formate;

(S)-N-((R)-1-(6-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)pyridin-3-yl)-3-(4-hydroxypiperidin-1-yl)propyl)-7-fluoro-7-isopropyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-1-(6-(2,4-dioxoimidazolidin-1-yl)pyridin-3-yl)-3-(4-hydroxypiperidin-1-yl)propyl)-7-(1-methylcyclopropyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-1-(6-(2,4-dioxoimidazolidin-1-yl)pyridin-3-yl)-3-(4-hydroxypiperidin-1-yl)propyl)-7-fluoro-7-isopropyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-7-(tert-butyl)-N-((R)-1-(6-(2,4-dioxoimidazolidin-1-yl)pyridin-3-yl)-3-(4-hydroxypiperidin-1-yl)propyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-1-(6-(2,4-dioxoimidazolidin-1-yl)pyridin-3-yl)-3-(4-hydroxypiperidin-1-yl)propyl)-7-(1-(trifluoromethyl)cyclopropyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

1-((R)-3-((S)-7-(tert-butyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamido)-3-(6-(2,4-dioxoimidazolidin-1-yl)pyridin-3-yl)propyl)piperidine-4-carboxylic acid;

1-((R)-3-((S)-7-(tert-butyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamido)-3-(4-(5-fluoro-6-hydroxypyridin-3-yl)phenyl)propyl)piperidine-4-carboxylic acid;

sodium 1-((R)-3-((S)-7-(tert-butyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamido)-3-(4-(5-fluoro-6-hydroxypyridin-3-yl)phenyl)propyl)piperidine-4-carboxylate;

(S)-N-((R)-3-amino-1-(3-(((S)-pyrrolidin-3-yl) carbamoyl)phenyl)propyl)-6-(tert-butyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(S)-7-(tert-butyl)-N-((R)-1-(4-((N,N-dimethylsulfamoyl)amino)-3-fluorophenyl)-3-(4-hydroxypiperidin-1-yl)propyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-7-(tert-butyl)-N-((R)-1-(6-(ethylsulfonyl)pyridin-3-yl)-3-(4-hydroxypiperidin-1-yl)propyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-7-(tert-butyl)-N-((R)-1-(4-(4-fluoro-5-hydroxypyridin-2-yl)phenyl)-3-(4-hydroxypiperidin-1-yl)propyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-3-amino-1-phenylpropyl)-6-(tert-butyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(S)-7-(tert-butyl)-N-((R)-3-(4-hydroxypiperidin-1-yl)-1-(4-(2-oxooxazolidin-3-yl)phenyl)propyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-3-(4-hydroxypiperidin-1-yl)-1-(4-(2-oxooxazolidin-3-yl)phenyl)propyl)-7-(1-methylcyclopropyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-3-(4-hydroxypiperidin-1-yl)-1-(4-(2-oxooxazolidin-3-yl)phenyl)propyl)-7-(1-(trifluoromethyl)cyclopropyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

7-fluoro-N-((R)-3-(4-hydroxypiperidin-1-yl)-1-(4-(2-oxooxazolidin-3-yl)phenyl)propyl)-7-isopropyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-1-(4-(5-fluoro-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-3-(4-hydroxypiperidin-1-yl)propyl)-7-(1-methylcyclopropyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-1-(4-(5-fluoro-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-3-(4-hydroxypiperidin-1-yl)propyl)-7-(1-(trifluoromethyl)cyclopropyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-7-(tert-butyl)-N-((R)-1-(4-(5-fluoro-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-3-(4-hydroxypiperidin-1-yl)propyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-1-[4-(5-chloro-6-hydroxypyridin-3-yl)phenyl]-3-piperidin-1-ylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(S)-6-(tert-butyl)-N-((R)-1-(4-(5-fluoro-6-hydroxypyridin-3-yl)phenyl)-3-(piperidin-1-yl)propyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-1-[4-(6-hydroxy-5-methylpyridin-3-yl)phenyl]-3-piperidin-1-ylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-1-[4-(6-hydroxy-2-methylpyridin-3-yl)phenyl]-3-piperidin-1-ylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-N-{(1R)-1-[4-(5-amino-6-hydroxypyridin-3-yl)phenyl]-3-piperidin-1-ylpropyl}-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-(1-phenyl-3-piperidin-1-ylpropyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-(3-morpholin-4-yl-1-phenylpropyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[3-(diethylamino)-1-phenylpropyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-(1-phenyl-3-piperazin-1-ylpropyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-1-phenyl-3-[(2,2,2-trifluoroethyl)amino]propyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-3-[(2-fluoroethyl)amino]-1-phenylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-1-phenyl-3-(tetrahydro-2H-pyran-4-ylamino) propyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-3-[(4-hydroxycyclohexyl)amino]-1-phenylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-3-(4-hydroxypiperidin-1-yl)-1-phenylpropyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-3-(3-hydroxypiperidin-1-yl)-1-phenylpropyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-3-(4-fluoropiperidin-1-yl)-1-phenylpropyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-1-phenyl-3-pyrrolidin-1-ylpropyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-3-[3-(hydroxymethyl) azetidin-1-yl]-1-phenylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-3-[4-(hydroxymethyl)piperidin-1-yl]-1-phenylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-3-(3-hydroxyazetidin-1-yl)-1-phenylpropyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-1-phenylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

1-[(3R)-3-({[(6S)-6-tert-butyl-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-2-yl]carbonyl}amino)-3-phenylpropyl]piperidine-4-carboxylic acid;

(6S)-6-tert-butyl-N-{(1R)-3-[3-(hydroxymethyl)pyrrolidin-1-yl]-1-phenylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-3-[(trans-3-hydroxycyclobutyl)amino]-1-phenylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-[(1R)-3-(3-hydroxypyrrolidin-1-yl)-1-phenylpropyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(6S)-6-tert-butyl-N-{(1R)-3-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]-1-phenylpropyl}-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide;

(S)-7-(tert-butyl)-N-((R)-3-(4-hydroxypiperidin-1-yl)-1-(6-(pyridazin-4-yl)pyridin-3-yl) propyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-3-(4-hydroxypiperidin-1-yl)-1-(6-(pyridazin-4-yl)pyridin-3-yl)propyl)-7-(1-methylcyclopropyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-7-fluoro-N-((R)-3-(4-hydroxypiperidin-1-yl)-1-(6-(pyridazin-4-yl)pyridin-3-yl) propyl)-7-isopropyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-7-(tert-butyl)-N-((R)-1-(5-fluoro-6-(pyridazin-4-yl)pyridin-3-yl)-3-(4-hydroxypiperidin-1-yl)propyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-1-(4-(1H-pyrazol-4-yl)phenyl)-3-(4-hydroxypiperidin-1-yl)propyl)-7-(1-methylcyclopropyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(S)-N-((R)-1-(4-(1H-pyrazol-4-yl)phenyl)-3-(4-hydroxypiperidin-1-yl)propyl)-7-(1-(trifluoromethyl)cyclopropyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

methyl 1-((R)-3-((S)-7-fluoro-7-isopropyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamido)-3-(6-(pyridazin-4-yl)pyridin-3-yl)propyl)piperidine-4-carboxylate;

1-((R)-3-((S)-7-fluoro-7-isopropyl-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamido)-3-(6-(pyridazin-4-yl)pyridin-3-yl)propyl)piperidine-4-carboxylic acid;

(R)-N-((R)-3-(4-(2H-tetrazol-5-yl)piperidin-1-yl)-1-(4-(5-fluoro-6-hydroxypyridin-3-yl)phenyl)propyl)-7-(tert-butyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide;

(7S)-7-(tert-butyl)-N-(1-(pyridin-4-yl)-3-(pyrrolidin-1-yl)propyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide; and

(S)-7-(tert-butyl)-N-((R)-1-(6-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)pyridin-3-yl)-3-(4-hydroxypiperidin-1-yl)propyl)-5,6,7,8-tetrahydrothiazolo[5,4-b]quinoline-2-carboxamide.

13. A pharmaceutical composition comprising an effective amount of a compound of claim 12 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

14. The pharmaceutical composition of claim 13 , further comprising one or more additional therapeutic agents.

15. A method for treatment of cardiometabolic diseases, kidney disease, or diabetes which comprises administering to a subject in need of such treatment a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, according to claim 1 .