IP Library › Granted Patent US 12,343,359
Granted Patent B2
US 12,343,359 · App. 17/613,391 · Granted Jul 1, 2025

Inhibitory interneuron treatment methods, uses and compositions for diabetes

Inventor: Zaman Mirzadeh (Phoenix, AZ)
Assignee: DIGNITY HEALTH
A61K35/30A61K9/0085A61K9/08A61P3/10
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Quick Facts
Patent No.
US 12,343,359
App. No.
17/613,391
Granted
Jul 1, 2025
Kind
B2
Abstract

Disclosed herein are compositions, methods of treatment, and uses of inhibitory interneuron precursors, derived from the brain's medial ganglionic eminence, or differentiated from iPSC or ESCs, for the treatment of pre-diabetes or diabetes. In some embodiments, compositions including inhibitory interneuron precursors are transplanted into the arcuate nucleus of the hypothalamus region of the brain, to treat, for example, diabetes, such as, type-2 diabetes, In further embodiments, inhibitory interneuron precursors are used in the manufacture of a medicament for the treatment of diabetes, for example, type-2 diabetes.

Claims (11)

1. A method for the treatment of a mammal having pre-diabetes or diabetes, comprising:

administering an effective amount of mammalian MGE (medial ganglionic eminence) precursor cells to one or more of an arcuate nucleus of the hypothalamus region of the brain, the mediobasal hypothalamus region of the brain, and the ventromedial hypothalamus region of the brain, wherein the mammalian MGE precursor cells form interneurons that functionally integrate with endogenous neurons such that an improvement in the symptoms of prediabetes or diabetes in the treated mammal is achieved.

2. The method of claim 1 , wherein the mammalian MGE precursor cells are administered by injection.

3. The method of claim 1 , wherein the mammalian MGE precursor cells are administered through transplantation with a catheter or needle.

4. The method of claim 1 , wherein the mammal has diabetes.

5. The method of claim 4 , wherein the diabetes is type 2 diabetes.

6. The method of claim 1 , wherein between about 20 nanoliters to 50 microliters of a suspension comprising the mammalian MGE precursor cells is administered.

7. The method of claim 1 , wherein the mammalian MGE precursor cells are embryonic MGE precursor cells.

8. The method of claim 1 , wherein the mammalian MGE precursor cells are cultured MGE precursor cells.

9. The method of claim 1 wherein the mammal is a human.

10. The method of claim 1 , wherein administration is to the arcuate nucleus of the hypothalamus region of the brain.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 25, 2023
From: MIRZADEH, ZAMAN
To: DIGNITY HEALTH
Reel/Frame 063433/0852 →
Continuity (2)
Provisional Application 62851752 · May 23, 2019
Related Publication 20220241343A1 · Aug 4, 2022
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