IP Library › Granted Patent US 12,540,173
Granted Patent B2
US 12,540,173 · App. 17/613,443 · Granted Feb 3, 2026

Methods of treating cancer by targeting ZSCAN4 activity in cancer stem cells

Inventors: Michal Zalzman (Baltimore, MD); Benjamin Portney (Baltimore, MD)
Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
C07K16/18A61P35/00C07K14/4703C12N15/113C07K2317/92C12N2310/10C12N2310/531
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Quick Facts
Patent No.
US 12,540,173
App. No.
17/613,443
Granted
Feb 3, 2026
Kind
B2
Abstract

Provided herein are methods of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of an agent that inhibits the activity of ZSCAN4 in cancer cells in the subject, thereby treating the cancer.

Claims (4)

1 . A composition for treating cancer in a subject, comprising an effective amount of an agent that inhibits the activity of ZSCAN4 in cancer cells in the subject and a pharmaceutically acceptable carrier, wherein the agent comprises a nucleic acid encoding an RNA interference molecule, wherein the RNA interference molecule comprises any of SEQ ID NOS:3-5.

2 . The composition of claim 1 , wherein the RNA interference molecule comprises SEQ ID NO:3.

3 . The composition of claim 1 , wherein the RNA interference molecule comprises SEQ ID NO:4.

4 . The composition of claim 1 , wherein the RNA interference molecule comprises SEQ ID NO:5.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 13, 2023
From: UNIVERSITY OF MARYLAND BALTIMORE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065859/0898 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 24, 2021
From: ZALZMAN, MICHAL; PORTNEY, BENJAMIN
To: UNIVERSITY OF MARYLAND, BALTIMORE
Reel/Frame 058202/0614 →
Continuity (2)
Provisional Application 62851325 · May 22, 2019
Related Publication 20220306730A1 · Sep 29, 2022
References Cited (5)
US 8901288B2 · Fellmann · 2014 [cited by examiner]
US 20140287511A1 · Ko · 2014 [cited by examiner]
US 20160030514A1 · Ko · 2016 [cited by examiner]
Portney, Benjamin, “The Role of ZSCAN4 in Cancer Stemness” Doctoral dissertation, 2018, publicly available from the University of Maryland, Baltimore Online Digital Archive. Retrieved Sep. 20, 2024 from the internet, ht… [cited by examiner]
Portney et al. 2018 “The Role of ZSCAN4 in Cancer Sternness” Doctoral dissertation, 2018, publicly available from the University of Maryland, Baltimore Online Digital Archive. http://hdl.handle.net/10713/8186 (Year: 201… [cited by examiner]