Benzotriazole derivative
The present invention provides a compound having Keap1 inhibitory effects and a pharmaceutical composition containing the same. Specifically, the present invention provides a compound represented by the following general formula (I): [wherein the symbols have the same meanings as those described in the description] or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing the same.
1 . A compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof:
wherein:
R represents a hydrogen atom or an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
R 1 and R 2 each independently represent a hydrogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkenyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, or an alkynyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
or R 1 and R 2 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
R 3 , R 4 , and R 6 each independently represent a hydrogen atom, a halogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkenyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkynyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, a cycloalkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, a nonaromatic heterocyclyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an aryl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, a heteroaryl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, or a cyano group;
R 5 represents (i) a hydrogen atom, or (ii) an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from the group consisting of a halogen atom, a hydroxy group, a cycloalkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, a phenyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, and an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
A has a structure represented by the following formula (II)
R 7 and R 8 each independently represent a hydrogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkenyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, or an alkynyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
or R 7 and R 8 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
ring B represents a bicyclic ring optionally substituted with 1 to 5 substituent(s) independently selected from the group consisting of a halogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkenyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkynyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, a cycloalkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, a nonaromatic heterocyclyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an aryl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, a heteroaryl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, and a cyano group;
the symbol
represents the point of attachment to the rest of molecule; and
Group E represents a group consisting of a halogen atom, a hydroxy group, and an alkoxy group optionally substituted with 1 to 5 halogen atom(s).
2 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein
R represents a hydrogen atom or an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
R 1 and R 2 each independently represent a hydrogen atom or an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
or R 1 and R 2 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
R 3 , R 4 , and R 6 each independently represent a hydrogen atom, a halogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, or an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
R 5 represents (i) a hydrogen atom, or (ii) an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from the group consisting of a halogen atom, a hydroxy group, a phenyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, and an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
R 7 and R 8 each independently represent a hydrogen atom or an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
or R 7 and R 8 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle optionally substituted with 1 to 5 substituent(s) independently selected from Group E; and
ring B represents a bicyclic ring optionally substituted with 1 to 5 substituent(s) independently selected from the group consisting of a halogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, and a cyano group.
3 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein
R represents a hydrogen atom or an alkyl group;
R 1 and R 2 each independently represent a hydrogen atom or an alkyl group;
or R 1 and R 2 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle;
R 3 , R 4 , and R 6 each independently represent a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group;
R 5 represents (i) a hydrogen atom, or (ii) an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from the group consisting of a halogen atom, a hydroxy group, a phenyl group, and an alkoxy group;
R 7 and R 8 each independently represent a hydrogen atom or an alkyl group;
or R 7 and R 8 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle optionally substituted with 1 to 5 substituent(s) independently selected from Group E; and
ring B represents a bicyclic ring optionally substituted with 1 to 5 substituent(s) independently selected from the group consisting of a halogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, and a cyano group.
4 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein
the compound has a structure represented by the following general formula (I-1):
R represents a hydrogen atom or an alkyl group;
R 1 and R 2 each independently represent a hydrogen atom or an alkyl group;
or R 1 and R 2 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle;
R 3 represents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group;
R 4 and R 6 each independently represent a hydrogen atom, an alkyl group, or an alkoxy group; and
R 5 represents a hydrogen atom or an alkyl group.
5 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein
R represents a hydrogen atom;
R 1 and R 2 each independently represent a hydrogen atom or an alkyl group;
or R 1 and R 2 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle;
R 3 represents an alkyl group;
R 4 represents an alkyl group;
R 5 represents an alkyl group; and
R 6 represents a hydrogen atom.
6 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein
A has a structure represented by any one of the following formulae (II-1) to (II-3):
wherein:
R 7 and R 8 each independently represent a hydrogen atom or an alkyl group;
or R 7 and R 8 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
X 1 and X 2 each independently represent CR 9 or a nitrogen atom;
R 9 each independently represents a hydrogen atom, a halogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, or a cyano group; and
ring D represents a 5 to 6 membered carbocycle or a 5 to 6 membered heterocycle, each of which is optionally substituted with 1 to 5 substituent(s) independently selected from the group consisting of a halogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, and a cyano group.
7 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein
A has a structure represented by any one of the following formulae (II-1-1) to (II-3-4):
wherein:
R 7 and R 8 each independently represent a hydrogen atom or an alkyl group;
or R 7 and R 8 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
X 1 and X 2 each independently represent CR 9 or a nitrogen atom;
Y 1 , Y 2 , Y 3 , and Y 4 each independently represent CR 10 or a nitrogen atom;
R 9 and R 10 each independently represent a hydrogen atom, a halogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, or a cyano group;
Q 1 and Q 2 each independently represent CR 11 R 12 , NR 13 , an oxygen atom, a sulfur atom, SO, or SO 2 ;
R 11 and R 12 each independently represent a hydrogen atom, a halogen atom, or an alkyl group;
R 13 each independently represents a hydrogen atom or an alkyl group;
Z represents NR 14 , an oxygen atom, or a sulfur atom;
R 14 represents a hydrogen atom or an alkyl group;
Q 3 represents (CU 1 U 2 ) n ;
U 1 and U 2 each independently represent a hydrogen atom, a halogen atom, or an alkyl group; and
n represents 1, 2, or 3.
8 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein
A has a structure represented by the following formula (II-1-1):
wherein:
R 7 and R 8 each independently represent a hydrogen atom or an alkyl group;
or R 7 and R 8 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle;
X 1 and X 2 each independently represent CR 9 ;
any one of Y 1 , Y 2 , Y 3 , and Y 4 represents a nitrogen atom, and the other three each independently represent CR 10 ;
R 9 each represents a hydrogen atom; and
R 10 each independently represents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group.
9 . The compound according to claim 1 represented by the following general formula (I-1-1) or a pharmaceutically acceptable salt thereof:
wherein:
R represents a hydrogen atom or an alkyl group;
R 1 and R 2 each independently represent a hydrogen atom or an alkyl group;
or R 1 and R 2 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle;
R 3 , R 4 , and R 6 each independently represent a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group;
R 5 represents (i) a hydrogen atom, or (ii) an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from the group consisting of a halogen atom, a hydroxy group, a phenyl group, and an alkoxy group;
R 7 and R 8 each independently represent a hydrogen atom or an alkyl group;
or R 7 and R 8 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle optionally substituted with 1 to 5 substituent(s) independently selected from Group E;
R 10 represents a hydrogen atom, a halogen atom, an alkyl group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, an alkoxy group optionally substituted with 1 to 5 substituent(s) independently selected from Group E, or a cyano group; and
Group E represents a group consisting of a halogen atom, a hydroxy group, and an alkoxy group optionally substituted with 1 to 5 halogen atom(s).
10 . The compound according to claim 9 or a pharmaceutically acceptable salt thereof, wherein
R represents a hydrogen atom or an alkyl group;
R 1 and R 2 each independently represent a hydrogen atom or an alkyl group;
or R 1 and R 2 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle;
R 3 represents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group;
R 4 represents a hydrogen atom or an alkyl group;
R 5 represents an alkyl group;
R 6 represents a hydrogen atom;
R 7 and R 8 each independently represent a hydrogen atom or an alkyl group;
or R 7 and R 8 are combined with the carbon atom to which they are attached to form a monocyclic carbocycle; and
R 10 represents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group.
11 . The compound according to claim 1 selected from the group consisting of
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-2,2-difluoro-6,7-dihydro-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-f][1,4]oxazepin-8 (9H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-2,2-difluoro-6,7-dihydro-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-f][1,4]oxazepin-8 (9H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-9-ethyl-2,2-difluoro-8,9-dihydro-[1,3]dioxolo[4′,5′:3,4]benzo[1,2-f][1,4]oxazepin-7 (6H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-9-ethyl-2,2-difluoro-8,9-dihydro-[1,3]dioxolo[4′,5′:3,4]benzo[1,2-f][1,4]oxazepin-7 (6H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,5,7,8,9-hexahydro-4H-indeno[5,6-f][1,4]oxazepin-4-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,5,7,8,9-hexahydro-4H-indeno[5,6-f][1,4]oxazepin-4-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,7,8,9,10-hexahydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,7,8,9,10-hexahydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4,8,9,10,11-hexahydronaphtho[1,2-f][1,4]oxazepin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4,8,9,10,11-hexahydronaphtho[1,2-f][1,4]oxazepin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,5,8,9,10-hexahydro-4H-indeno[5,4-f][1,4]oxazepin-4-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,5,8,9,10-hexahydro-4H-indeno[5,4-f][1,4]oxazepin-4-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,8,9,10,11-hexahydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,8,9,10,11-hexahydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-10-methyl-2,3-dihydro-[1,4]oxazepino [7,6-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-10-methyl-2,3-dihydro-[1,4]oxazepino [7,6-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-8-methyl-2,3-dihydro-[1,4]oxazepino [7,6-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-8-methyl-2,3-dihydro-[1,4]oxazepino [7,6-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-1,5,7,8-tetrahydro-6H-[1,4]oxazepino [6,7-f]indazol-6-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-1,5,7,8-tetrahydro-6H-[1,4]oxazepino [6,7-f]indazol-6-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4-dihydronaphtho[1,2-f][1,4]oxazepin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4-dihydronaphtho[1,2-f][1,4]oxazepin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-8,9-dihydro-[1,4]oxazepino [7,6-h]quinolin-10 (11H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-8,9-dihydro-[1,4]oxazepino [7,6-h]quinolin-10 (11H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4-dihydro-[1,4]oxazepino [6,7-f]quinolin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4-dihydro-[1,4]oxazepino [6,7-f]quinolin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4-dihydro-[1,4]oxazepino [7,6-c]quinolin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4-dihydro-[1,4]oxazepino [7,6-c]quinolin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-7-ethyl-1,7,8,10-tetrahydro-9H-[1,4]oxazepino [7,6-g]indazol-9-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-7-ethyl-1,7,8,10-tetrahydro-9H-[1,4]oxazepino [7,6-g]indazol-9-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-7-ethyl-1-methyl-1,7,8,10-tetrahydro-9H-[1,4]oxazepino [7,6-g]indazol-9-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-7-ethyl-1-methyl-1,7,8,10-tetrahydro-9H-[1,4]oxazepino [7,6-g]indazol-9-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-7-ethyl-2-methyl-2,7,8,10-tetrahydro-9H-[1,4]oxazepino [7,6-g]indazol-9-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-7-ethyl-2-methyl-2,7,8,10-tetrahydro-9H-[1,4]oxazepino [7,6-g]indazol-9-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-1,3,4,9,10,11-hexahydro-2H-pyrimido[1′,2′: 1,6]pyrido[2,3-f][1,4]oxazepin-2-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-c]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-c]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-c]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-c]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-h]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-h]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-f]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-f]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-7-fluoro-2,3-dihydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-7-fluoro-2,3-dihydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-1-methyl-1,5,7,8-tetrahydro-6H-[1,4]oxazepino [6,7-f]indazol-6-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-1-methyl-1,5,7,8-tetrahydro-6H-[1,4]oxazepino [6,7-f]indazol-6-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-2-methyl-2,5,7,8-tetrahydro-6H-[1,4]oxazepino [6,7-f]indazol-6-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-2-methyl-2,5,7,8-tetrahydro-6H-[1,4]oxazepino [6,7-f]indazol-6-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-g]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-g]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-7-fluoro-2,3-dihydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-7-fluoro-2,3-dihydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-f]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-f]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
ethyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl) propanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl) propanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((S)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((S)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1-ethyl-4-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoate;
3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1-ethyl-4-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-((2,2-dimethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-((2,2-dimethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-2,2-dimethyl-6,7-dihydro-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-f][1,4]oxazepin-8 (9H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-2,2-dimethyl-6,7-dihydro-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-f][1,4]oxazepin-8 (9H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-h]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(3-((2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoate;
3-(3-((2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-1,6,7,9-tetrahydro-8H-[1,4]oxazepino [7,6-f]indazol-8-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-1,6,7,9-tetrahydro-8H-[1,4]oxazepino [7,6-f]indazol-8-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-1-methyl-1,6,7,9-tetrahydro-8H-[1,4]oxazepino [7,6-f]indazol-8-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-1-methyl-1,6,7,9-tetrahydro-8H-[1,4]oxazepino [7,6-f]indazol-8-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-2-methyl-2,6,7,9-tetrahydro-8H-[1,4]oxazepino [7,6-f]indazol-8-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-2-methyl-2,6,7,9-tetrahydro-8H-[1,4]oxazepino [7,6-f]indazol-8-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(3-(((R)-7-chloro-2-ethyl-2,3-dihydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoate;
3-(3-(((R)-7-chloro-2-ethyl-2,3-dihydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
methyl 3-(3-(((R)-7-chloro-2-ethyl-2,3-dihydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoate;
3-(3-(((R)-7-chloro-2-ethyl-2,3-dihydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
3-(3-(((R)-10-chloro-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-10-methoxy-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-10-methoxy-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-10-methyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-10-methyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydrothieno[2′,3′: 4,5]benzo[1,2-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydrothieno[2′,3′: 4,5]benzo[1,2-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,7,8-tetrahydrothieno[2′,3′: 4,5]benzo[1,2-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,7,8-tetrahydrothieno[2′,3′: 4,5]benzo[1,2-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-9,9-dioxide-2,3,7,8-tetrahydrothieno[2′,3′: 4,5]benzo[1,2-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-9,9-dioxide-2,3,7,8-tetrahydrothieno[2′,3′: 4,5]benzo[1,2-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethyl-3-(4-methyl-3-(((R)-2-methyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl) propanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethyl-3-(4-methyl-3-(((R)-2-methyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl) propanoic acid;
methyl 3-(3-((3′H-spiro[cyclopropane-1,2′-[1,4]oxazepino [7,6-g]quinoline]-4′ (5′H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoate;
3-(3-((3′H-spiro[cyclopropane-1,2′-[1,4]oxazepino [7,6-g]quinoline]-4′ (5′H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethyl-3-(4-methyl-3-((2-propyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl) propanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethyl-3-(4-methyl-3-((2-propyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl) propanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl)-2,2-dimethylpropanoic acid;
methyl 3-(4-chloro-3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoate;
3-(4-chloro-3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methoxyphenyl)-2,2-dimethylpropanoate;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methoxyphenyl)-2,2-dimethylpropanoic acid;
methyl 3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethyl-3-(1-methyl-1H-benzo[d][1,2,3]triazol-5-yl) propanoate;
3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethyl-3-(1-methyl-1H-benzo[d][1,2,3]triazol-5-yl) propanoic acid;
methyl 1-((1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl) (3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)methyl)cyclopentane-1-carboxylate;
1-((1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl) (3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)methyl)cyclopentane-1-carboxylic acid;
methyl 1-((1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl) (3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)methyl)cyclobutane-1-carboxylate;
1-((1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl) (3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)methyl)cyclobutane-1-carboxylic acid;
methyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((S)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-c]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoate; and
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((S)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-c]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid or a pharmaceutically acceptable salt thereof.
12 . The compound according to claim 1 selected from the group consisting of
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-2,2-difluoro-6,7-dihydro-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-f][1,4]oxazepin-8 (9H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-9-ethyl-2,2-difluoro-8,9-dihydro-[1,3]dioxolo[4′,5′:3,4]benzo[1,2-f][1,4]oxazepin-7 (6H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,5,7,8,9-hexahydro-4H-indeno[5,6-f][1,4]oxazepin-4-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,7,8,9,10-hexahydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4,8,9,10,11-hexahydronaphtho[1,2-f][1,4]oxazepin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,5,8,9,10-hexahydro-4H-indeno[5,4-f][1,4]oxazepin-4-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,8,9,10,11-hexahydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-10-methyl-2,3-dihydro-[1,4]oxazepino [7,6-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-8-methyl-2,3-dihydro-[1,4]oxazepino [7,6-b]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-1,5,7,8-tetrahydro-6H-[1,4]oxazepino [6,7-f]indazol-6-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4-dihydronaphtho[1,2-f][1,4]oxazepin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-8,9-dihydro-[1,4]oxazepino [7,6-h]quinolin-10 (11H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4-dihydro-[1,4]oxazepino [6,7-f]quinolin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-3,4-dihydro-[1,4]oxazepino [7,6-c]quinolin-2 (1H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-7-ethyl-1,7,8,10-tetrahydro-9H-[1,4]oxazepino [7,6-g]indazol-9-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-7-ethyl-1-methyl-1,7,8,10-tetrahydro-9H-[1,4]oxazepino [7,6-g]indazol-9-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-7-ethyl-2-methyl-2,7,8,10-tetrahydro-9H-[1,4]oxazepino [7,6-g]indazol-9-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-4-ethyl-1,3,4,9,10,11-hexahydro-2H-pyrimido[1′,2′: 1,6]pyrido[2,3-f][1,4]oxazepin-2-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-c]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-c]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-h]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-f]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-7-fluoro-2,3-dihydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-1-methyl-1,5,7,8-tetrahydro-6H-[1,4]oxazepino [6,7-f]indazol-6-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-8-ethyl-2-methyl-2,5,7,8-tetrahydro-6H-[1,4]oxazepino [6,7-f]indazol-6-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-g]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-7-fluoro-2,3-dihydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-f]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl) propanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((S)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1-ethyl-4-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-((2,2-dimethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-2,2-dimethyl-6,7-dihydro-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-f][1,4]oxazepin-8 (9H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-h]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(3-((2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-1,6,7,9-tetrahydro-8H-[1,4]oxazepino [7,6-f]indazol-8-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-1-methyl-1,6,7,9-tetrahydro-8H-[1,4]oxazepino [7,6-f]indazol-8-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-6-ethyl-2-methyl-2,6,7,9-tetrahydro-8H-[1,4]oxazepino [7,6-f]indazol-8-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(3-(((R)-7-chloro-2-ethyl-2,3-dihydronaphtho[2,1-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
3-(3-(((R)-7-chloro-2-ethyl-2,3-dihydronaphtho[2,3-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
3-(3-(((R)-10-chloro-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-10-methoxy-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-10-methyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydrothieno[2′,3′: 4,5]benzo[1,2-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3,7,8-tetrahydrothieno[2′,3′: 4,5]benzo[1,2-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-9,9-dioxide-2,3,7,8-tetrahydrothieno[2′,3′: 4,5]benzo[1,2-f][1,4]oxazepin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethyl-3-(4-methyl-3-(((R)-2-methyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl) propanoic acid;
3-(3-((3′H-spiro[cyclopropane-1,2′-[1,4]oxazepino [7,6-g]quinoline]-4′ (5′H)-yl)methyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethyl-3-(4-methyl-3-((2-propyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl) propanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl)-2,2-dimethylpropanoic acid;
3-(4-chloro-3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)phenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-dimethylpropanoic acid;
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methoxyphenyl)-2,2-dimethylpropanoic acid;
3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethyl-3-(1-methyl-1H-benzo[d][1,2,3]triazol-5-yl) propanoic acid;
1-((1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl) (3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)methyl)cyclopentane-1-carboxylic acid;
1-((1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl) (3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino [7,6-g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)methyl)cyclobutane-1-carboxylic acid; and
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((S)-2-ethyl-2,3-dihydro-[1,4]oxazepino [6,7-c]isoquinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid
or a pharmaceutically acceptable salt thereof.
13 . A pharmaceutical composition comprising the compound according to claim 1 or a pharmaceutically acceptable salt thereof.
14 . A method for prevention, alleviation, and/or treatment of a disease which is improved by the inhibition of Keap1, comprising administering the pharmaceutical composition according to claim 13 to a subject in need thereof.
15 . The pharmaceutical composition according to claim 14 , wherein the disease which is improved by the inhibition of Keap1 is a renal disease.
16 . The compound according to claim 1 , which is 3-(1,4-dimethyl-1H-benzo [d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino[7,6-g]quinolin- 4(5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid,
or a pharmaceutically acceptable salt thereof.
17 . The compound according to claim 1 , which is 3-(1,4-dimethyl-1H-benzo [d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino[6,7-c]isoquinolin- 4(5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid,
or a pharmaceutically acceptable salt thereof.
18 . The compound according to claim 1 , which is 3-(1,4-dimethyl-1H-benzo [d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino[6,7-c]quinolin- 4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid,
or a pharmaceutically acceptable salt thereof.
19 . The compound according to claim 1 , which is 3-(1,4-dimethyl-1H-benzo [d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-10-methoxy-2,3-dihydro-[1,4]oxazepino[7,6- g]quinolin-4 (5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid,
or a pharmaceutically acceptable salt thereof.
20 . The compound according to claim 1 , which is 1-((1,4-dimethyl-1H-benzo [d][1,2,3]triazol-5-yl)(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino[7,6-g]quinolin-4(5H)- y1)methyl)-4-methylphenyl)methyl)cyclobutane-1-carboxylic acid,
or a pharmaceutically acceptable salt thereof.