Method for synthesizing furoimidazopyridine compound, polymorphic substance and polymorphic substance of salt
A method for synthesizing a compound 2-[(2R,5S)-5-[2-methylfuro[3,2-b]imidazo[4,5-d]pyridin-1-yl]tetrahydropyran-2-yl]acetonitr ile as a selective JAK1/TYK2 kinase inhibitor. The compound is prepared by taking 7-chloro-6-nitrofuro[3,2-b]pyridine as the starting material, and by nucleophilic substitution, palladium on carbon reduction and cyclization reactions. The present synthesis method has mild reaction conditions, high product yield and high purity, and is suitable for industrial production. A crystal form of the compound, crystal forms of the salts thereof and preparation methods thereof. The crystal form of the compound and the crystal forms of the salts thereof have good physical and chemical properties and are suitable for drug development.
1. Crystal form O of a tartrate of a compound of formula I
wherein the X-ray powder diffraction pattern of the crystal form shows characteristic peaks at 2theta angles of 6.3°±0.2°, 26.1°±0.2° and 26.9°±0.2°.
2. The crystal form O of a tartrate of a compound of formula I according to claim 1 , wherein the X-ray powder diffraction pattern of the crystal form shows characteristic peaks at 2theta angles of 6.3°±0.2°, 12.5°±0.2°, 15.1°±0.2°, 26.1°±0.2°, 26.9°±0.2° and 27.5°±0.2°.
3. The crystal form O of a tartrate of a compound of formula I according to claim 1 , wherein the X-ray powder diffraction pattern of the crystal form shows characteristic peaks at 2theta angles of 6.3°±0.2°, 11.4°±0.2°, 12.5°±0.2°, 14.1°±0.2°, 14.4°±0.2°, 15.1°±0.2°, 26.1°±0.2°, 26.9°±0.2° and 27.5°±0.2°.