Granted Patent
B2
US 12,595,252 · App. 17/615,907 · Granted Apr 7, 2026
Inhibitors of SARM1
Inventors:
Robert Owen Hughes (Newtown, CT); Rajesh Devraj (Chesterfield, MO); Todd Bosanac (New Milford, CT); Richard Andrew Jarjes-Pike (Newbury, GB); Andrew Simon Brearley (Chilton, GB); Jonathan Bentley (Abindgon, GB); Shelley Anne Parrott (Abindgon, GB); Sophie Catherine Cooper (Abindgon, GB)
Assignee:
DISARM THERAPEUTICS, INC.
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Abstract
The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
Claims (5)
1 . A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2 . A method comprising a step of: administering a compound of claim 1 to a subject who (i) has a condition characterized by axonal degeneration or (ii) is at risk of developing a condition characterized by axonal degeneration.
3 . A method of treating or preventing axonal degeneration comprising administering to a subject in need thereof a compound of claim 1 .
4 . A method of inhibiting SARM1 comprising contacting a biological sample with a compound of claim 1 .
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 2, 2021
From: JARJES-PIKE, RICHARD ANDREW; BREARLEY, ANDREW SIMON; BENTLEY, JONATHAN; PARROTT, SHELLEY ANNE; COOPER, SOPHIE CATHERINE
To: EVOTEC (UK) LTD
Reel/Frame 058267/0888 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 2, 2021
From: EVOTEC (UK) LTD
To: EVOTEC INTERNATIONAL GMBH
Reel/Frame 058267/0922 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 2, 2021
From: HUGHES, ROBERT OWEN; DEVRAJ, RAJESH; BOSANAC, TODD; EVOTEC INTERNATIONAL GMBH
To: DISARM THERAPEUTICS, INC.
Reel/Frame 058268/0018 →
Continuity (2)
Provisional Application
62861501
· Jun 14, 2019
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