IP Library › Granted Patent US 12,612,376
Granted Patent B2
US 12,612,376 · App. 17/622,283 · Granted Apr 28, 2026

Process for synthesizing 5-hydroxymethylfurfural

Inventors: Marc Jacquin (Rueil-Malmaison, FR); Damien Delcroix (Rueil-Malmaison, FR); Kim Larmier (Rueil-Malmaison, FR); Thierry Huard (Rueil-Malmaison, FR)
Assignee: IFP Energies Nouvelles
C07D307/46
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Quick Facts
Patent No.
US 12,612,376
App. No.
17/622,283
Granted
Apr 28, 2026
Kind
B2
Abstract

The invention relates to a process for the production of a mixture of 5-hydroxymethylfurfural and glucose from a feedstock containing fructose in the presence of at least one polar aprotic solvent and of at least one dehydration catalyst, in which process the reaction temperature is less than 90° C.

Claims (10)

1 . A process for 5-hydroxymethylfurfural, comprising bringing a feedstock of sucrose or a mixture of glucose and fructose into contact with methanesulfonic acid and/or HCl as catalyst in dimethyl sulfoxide as solvent, said process being carried out at a temperature of 50 to 90° C. and which process selectively converts fructoside units of the feedstock in contrast to the glucoside units of the feedstock, and in which the feedstock is introduced in an initial concentration by weight of fructoside units of greater than or equal to 7% by weight with respect to the total weight of the dimethyl sulfoxide.

2 . The process as claimed in claim 1 , which is carried out at a temperature of 60 to 85° C.

3 . The process as claimed in claim 1 , in which the conversion of the fructoside fraction into 5-HMF is greater than or equal to 70% and the conversion of the non-fructoside fraction is less than or equal to 20%.

4 . The process as claimed in claim 1 , in which the feedstock is introduced at a dimethyl sulfoxide/feedstock ratio by weight of 0.1 to 200.

5 . The process as claimed in claim 1 , in which the methanesulfonic acid as catalyst is introduced in a dimethyl sulfoxide/methanesulfonic acid ratio by weight of 20 to 10 000, in which the weight of dimethyl sulfoxide corresponds to the total weight of dimethyl sulfoxide in the process.

6 . The process as claimed in claim 1 , in which the catalyst is HCl.

7 . The process as claimed in claim 1 , in which the feedstock is introduced in an initial concentration by weight of fructoside unit of 8% to 30% by weight, with respect to the total weight of solvent.

8 . The process as claimed in claim 1 , which is carried out at a temperature of 65 to 75° C.

9 . The process as claimed in claim 1 , which is carried out at a temperature of 50 to 65° C.

10 . The process as claimed in claim 1 , in which the catalyst is methanesulfonic acid.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 9, 2022
From: JACQUIN, MARC; DELCROIX, DAMIEN; LARMIER, KIM; HUARD, THIERRY
To: IFP ENERGIES NOUVELLES
Reel/Frame 059356/0363 →
Priority Claims (1)
FR 1906806 · Jun 24, 2019 · national
Continuity (1)
Related Publication 20220242840A1 · Aug 4, 2022
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