Granted Patent
B2
US 12,746,411 · App. 17/627,701 · Granted Sep 29, 2026
Selective laser stimulation of corneal stem cells
Assignee:
BELKIN VISION LTD.
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Abstract
Apparatus ( 20 ) for ophthalmic treatment includes an optical unit ( 30 ), which includes a camera ( 54 ), which is configured to capture an image of an eye ( 25 ) of a patient, a laser ( 48 ), which is configured to emit pulses of laser radiation, and beam conditioning and scanning optics ( 49, 50 ), which are configured to focus and direct the laser radiation to impinge on an anterior surface of the eye. A controller ( 44 ) is configured to analyze the image so as to identify a limbus of the eye, and to control the optical unit so that the laser radiation impinges on a set of one or more locations on the anterior surface of the eye that are in a vicinity of the limbus with a pulse duration and an energy selected so as to stem cells at the one or more locations.
Claims (13)
1 . Apparatus for treating an eye of a patient, the apparatus comprising:
an optical unit, comprising:
a laser, which is configured to emit laser radiation, wherein the laser radiation is pulsed, with a pulse duration that is less than 1 us and an energy that is less than 5 mJ per pulse;
one or more mirrors positioned around an optical axis of the eye; and
beam conditioning and scanning optics, which are configured to focus and direct the laser radiation to reflect from the one or more mirrors so as to impinge on an anterior surface of the eye at an oblique angle relative to the optical axis with a beam diameter no greater than 1 mm; and
a controller, which is configured to control the optical unit so that the laser radiation impinges on the eye at the oblique angle in a set of one or more locations in a vicinity of the limbus with a fluence selected so as to stimulate stem cells at the one or more locations.
2 . The apparatus according to claim 1 , wherein the one or more mirrors comprise a ring mirror, which surrounds the optical axis.
3 . The apparatus according to claim 1 , wherein the controller is configured to control the optical unit so that the laser radiation impinges on and stimulates the stem cells in a epithelium of the eye.
4 . The apparatus according to claim 1 , wherein the controller is configured to control the optical unit so that the laser radiation impinges on and stimulates the stem cells in a stroma of the eye.
5 . The apparatus according to claim 1 , wherein the controller is configured to control the optical unit so that the laser radiation impinges on and stimulates the stem cells in an endothelium of the eye.
6 . The apparatus according to claim 1 , wherein the pulse duration is less than 100 ns.
7 . The apparatus according to claim 1 , wherein the energy per pulse is less than 3 mJ.
8 . The apparatus according to claim 1 , wherein the laser radiation is focused to impinge on each of the one or more locations with a fluence less than 0.4 J/cm 2 .
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 17, 2022
From: BELKIN, MICHAEL; SACKS, ZACHARY
To: BELKIN VISION LTD.
Reel/Frame 058669/0228 →
Continuity (2)
Provisional Application
62899162
· Sep 12, 2019
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