IP Library Granted Patent US 12,527,764
Granted Patent B2
US 12,527,764 · App. 17/629,333 · Granted Jan 20, 2026

Methods and compositions for treating androgen receptor deficient, androgen receptor low, and castration-resistant prostate cancers

Inventor: Andrew Hsieh (Seattle, WA)
Assignee: Fred Hutchinson Cancer Center
A61K31/4025A61K31/167A61K31/277A61K31/4166A61K31/4188A61K31/426A61K31/427A61K31/4439A61K31/519A61K31/58A61K38/09A61P35/00
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Quick Facts
Patent No.
US 12,527,764
App. No.
17/629,333
Granted
Jan 20, 2026
Kind
B2
Abstract

Methods and compositions for treatment of prostate cancers, such as androgen receptor (AR) deficient and androgen receptor (AR) low cancers, are disclosed. The methods include administration of an agent that inhibits activity of eIF4F or an agent that disrupts the eIF4F translation-initiation complex (composed of eIF4E, eIF4A, and eIF4G).

Claims (7)

1 . A method for treatment of androgen-receptor deficient, androgen-receptor low, or castration-resistant prostate cancer, the method comprising administering to a subject in need thereof a therapeutically effective amount of an agent that disrupts eIF4F translation-initiation complexes;

wherein the agent inhibits activity of eIF4E translation initiation factor and comprises 4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid (4E1RCat), 5-[5-[(E)-(3-Benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene) methyl]furan-2-yl]-2-chlorobenzoic acid (4E2RCat), or α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]-hydrazinylidene]-2-nitro-benzene-propanoic acid (4EGI-1); or

wherein the agent is an inhibitor of eIF4A and comprises silvesterol, hippuristanol, rocaglates, pateamine A, elatol, sanguinarine, elisabatin A, 15d-PGJ2, eFT226, or a combination thereof.

2 . The method of claim 1 , wherein the prostate cancer is androgen-receptor deficient prostate cancer.

3 . The method of claim 1 , wherein the method further comprises administering to the subject a therapeutically effective amount of an additional agent that is a peptide, wherein the peptide is a peptide mimetic of non-phosphorylated 4EBP1.

4 . The method of claim 1 , wherein the method further comprises administering to the subject a therapeutically effective amount of an androgen lowering agent, an androgen receptor blocker, or a combination thereof; wherein the androgen lowering agent is abiraterone, TAK700, buserelin, goserelin, leuproelin, degarelix, or a combination thereof; and wherein the androgen blocker is enzalutamide, bicalutamide, apalutamide, flutamide, nilutamide, finasteride, dutasteride, or a combination thereof.

5 . The method of claim 4 , wherein the androgen lowering agent, the androgen receptor blocker, or the combination thereof is administered prior to administration of the agent or together with administration of the agent.

Assignments (2)
MERGER AND CHANGE OF NAME Recorded Jun 8, 2022
From: FRED HUTCHINSON CANCER RESEARCH CENTER; SEATTLE CANCER CARE ALLIANCE
To: FRED HUTCHINSON CANCER CENTER
Reel/Frame 060838/0852 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 17, 2022
From: HSIEH, ANDREW
To: FRED HUTCHINSON CANCER RESEARCH CENTER
Reel/Frame 059038/0768 →
Continuity (2)
Provisional Application 62877732 · Jul 23, 2019
Related Publication 20220249439A1 · Aug 11, 2022
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