Dynamic coordinated reset (DCR) stimulation
A neurostimulator is configured to activate a set of N electrodes, which are each adapted to stimulate at least a portion of a population of neurons when activated and applied in an invasive manner, at respective onset times T 1 . . . T N throughout a cycle period T. N is an integer larger than two and the cycle period T is defined as a time period within which each of the N electrodes is activated exactly once. The onset times T 1 . . . T N are not arranged substantially uniformly throughout the cycle period T.
1. A neurostimulator configured to:
activate a set of N electrodes, which are each adapted to stimulate at least a portion of a population of neurons when activated and applied in an invasive manner, at respective onset times T 1 . . . T N throughout a cycle period T, wherein N is an integer larger than two and wherein the cycle period T is defined as a time period within which each of the N electrodes is activated exactly once, and wherein the onset times T 1 . . . T N are not arranged substantially uniformly throughout the cycle period T.
2. The neurostimulator according to claim 1 , being further configured to activate the set of N electrodes at the respective onset times T 1 . . . T N based at least in part on a state of at least a portion of the population of neurons, wherein the neurostimulator is configured to determine the state based at least in part on determining one or more electrodes that were activated before in the cycle period and/or based at least in part on determining one or more respective onset times at which one or more of the electrodes were activated before in the cycle period and/or based at least in part on a refractory period of at least a portion of the population of neurons.
3. The neurostimulator according to claim 1 , wherein the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period T are substantially determined by a function that is nonlinear with respect to i.
4. The neurostimulator according to claim 1 , wherein:
the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period T are substantially given by T i =T/N·(i−1)+T/2N·(1+(−1) i )·C, wherein −1<C<0; or
the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period T are substantially given by T i =T/N·(i−1)+T/2N·(1+(−1) i )·C, wherein 0<C<1.
5. The neurostimulator according to claim 1 , wherein:
the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period T are substantially given by T i =T/N·(i−1)·C, wherein 0<C<1; or
the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period T are substantially given by T i =1/N·(i−1)·C, wherein 1<C<N/N−1.
6. The neurostimulator according to claim 1 , wherein:
the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period T are substantially given by T i =T/N·(i−1)+T·C, wherein C=0 for i=1 and −1/N<C<0 for i>1; or
the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period are substantially given by T i =T/N·(i−1)+T·C, wherein 0<C<1/N.
7. The neurostimulator according to claim 1 , wherein:
the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period T are substantially given by T i =T/N·(i−1)+T·(N+1−i)·C, wherein C=0 for i=1 and − 1 /N·(N−1)<C<0 for i>1; or
the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period T ( 150 ) are substantially given by T i =T/N·(i−1)+T·(N+1−i)·C, wherein 0<C<1/N.
8. The neurostimulator according to claim 1 , wherein:
the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period T are substantially given by T 1 =0 for i=1 and by T i =T i−1 +T/N·C N+1−i for i>1, wherein 0<C<1; or
the onset times T 1 . . . T N at which a respective i-th electrode of the N electrodes is activated in the cycle period T are substantially given by T 1 =0 for i=1 and by T i =T i−1 +T/N·C N+1−i for i>1, wherein 1<C and C N −C/C−1<N.
9. The neurostimulator according to claim 1 , being configured such that, at the respective onset time, the N electrodes are respectively activated for a respective activation time each and the activation times overlap in time not at all or only in part.
10. The neurostimulator according to claim 1 , being further configured to activate the set of N electrodes throughout at least two and at most one hundred consecutive cycle periods.
11. The neurostimulator according to claim 1 , being further configured to activate a further set of M electrodes different from the set of N electrodes throughout at least two and at most one hundred cycle periods based at least in part on a state of the population of neurons, wherein M is an integer.
12. The neurostimulator according to claim 1 , being further configured to not activate any of the electrodes for a duration corresponding to at least one cycle period and at most one hundred cycle periods in alternation with activating the electrodes throughout at least one and at most one hundred consecutive cycle periods.
13. The neurostimulator according to claim 4 , being further configured to determine C based at least in part on an intensity of symptoms resulting from synchronized neuronal brain activity.
14. The neurostimulator according to claim 13 , being further configured to determine C by carrying out stimulations using values of C that lie around an initial value of C determined based at least in part on the intensity of the symptoms.
15. The neurostimulator according to claim 1 , wherein the neurostimulator comprises stimulation leads connected to the electrodes and one or more computer processors configured by computer program code to perform the step of activating the set of N electrodes via the stimulation leads.
16. The neurostimulator according to claim 15 , further comprising the electrodes which are applied in the invasive manner in a brain.
17. The neurostimulator according to claim 15 , wherein the one or more computer processors are associated with a pulse generator which is configured to generate pulses for activating the set of N electrodes via the stimulation leads such that the onset times T 1 . . . T N are not arranged substantially uniformly throughout the cycle period T.
18. A method for neurostimulation comprising:
activating a set of N electrodes, which are each adapted to stimulate at least a portion of a population of neurons when activated and applied in an invasive manner, at respective onset times T 1 . . . T N throughout a cycle period T, wherein N is an integer larger than two and wherein the cycle period T is defined as a time period within which each of the N electrodes is activated exactly once, and wherein the onset times T 1 . . . T N are not arranged substantially uniformly throughout the cycle period T.
19. The method according to claim 18 , wherein the method is performed with the electrodes applied in the invasive manner in a brain for desynchronizing neuronal brain activity.
20. A tangible, non-transitory computer-readable medium comprising instructions, which upon being executed by one or more computer processors of a neurostimulator, cause execution of the following steps:
activating a set of N electrodes, which are each adapted to stimulate at least a portion of a population of neurons when activated and applied in an invasive manner, at respective onset times T 1 . . . T N throughout a cycle period T, wherein N is an integer larger than two and wherein the cycle period T is defined as a time period within which each of the N electrodes is activated exactly once, and wherein the onset times T 1 . . . T N are not arranged substantially uniformly throughout the cycle period T.