SOLVENT DELIVERY SYSTEM FOR TOPICAL DELIVERY OF ACTIVE AGENTS
Topical compositions for dermatological use are described. The topical compositions generally comprise a carbo late ester, a monohydric aliphatic alcohol, and a lipophilic compound with logP greater than about 3.00. The compositions may further comprise a polyol and a hydrophilic compound with logP less than about −2.00 optionally in lieu of the lipophilic compound.
1 - 7 . (canceled)
8 . A topical composition, comprising:
a carboxylate ester,
a monohydric aliphatic alcohol, and
a lipophilic compound with logP>5.00
9 . The topical composition of claim 8 , wherein the lipophilic active agent is a non-steroidal anti-inflammatory agent.
10 . (canceled)
11 . The topical composition of claim 8 , wherein the lipophilic active agent is an antihistamine.
12 . The topical composition of claim 8 , wherein the antihistamine is ebastine, fexofenadine, loratadine, or clemastine.
13 . The topical composition of claim 8 , wherein the lipophilic active agent is a photosensitizing agent.
14 . (canceled)
15 . The topical composition of claim 8 , wherein the lipophilic active agent is an antifungal agent.
16 . The topical composition of claim 8 , wherein the antifungal agent is oxiconazole or econazole.
17 - 43 . (canceled)
44 . A topical composition, comprising:
a carboxylate ester,
a polyol,
a monohydric aliphatic alcohol, and
a lipophilic compound with logP>5.00.
45 . The topical composition of claim 44 , wherein the lipophilic active agent is a non-steroidal anti-inflammatory agent.
46 . (canceled)
47 . The topical composition of claim 44 , wherein the lipophilic active agent is an antihistamine.
48 . The topical composition of claim 44 , wherein the antihistamine is ebastine, fexofenadine, loratadine, or clemastine.
49 - 50 . (canceled)
51 . The topical composition of claim 44 , wherein the lipophilic active agent is an antifungal agent.
52 . The topical composition of claim 44 , wherein the antifungal agent is a miconazole, oxiconazole or econazole.
53 - 75 . (canceled)
76 . A topical composition, comprising:
a carboxylate ester,
a polyol,
a monohydric aliphatic alcohol, and
an active agent that is a salt.
77 . The topical composition of claim 76 , wherein the salt is an anesthetics or analgesic agent.
78 . The topical composition of claim 76 , wherein the anesthetics or analgesic agent is lidocaine hydrochloride or tetracaine hydrochloride, or a combination thereof.
79 . The topical composition of claim 76 , wherein the salt is an antihistamine.
80 . The topical composition of claim 76 , wherein the antihistamine is cetirizine hydrochloride.
81 . The topical composition of claim 76 , wherein the salt is an antibiotic.
82 - 93 . (canceled)
94 . A topical composition, comprising:
a carboxylate ester,
a polyol,
a monohydric aliphatic alcohol, and
an active agent comprising at least one polar compound.
95 . The composition of claim 94 , wherein the polar compound is a vasodilating agent.
96 . The composition of claim 94 , wherein the vasodilating agent is minoxidil.
97 . The composition of claim 94 , wherein the polar compound is an antibiotic.
98 . (canceled)
99 . The composition of claim 94 , wherein the polar compound is an anesthetics or analgesic agent.
100 . The composition of claim 94 , wherein the anesthetics or analgesic agent is lidocaine hydrochloride or tetracaine hydrochloride, or a combination thereof.
101 - 122 . (canceled)
123 . The topical composition of claim 44 , wherein the polyol is selected from the group consisting of propylene glycol, glycerol and glycerin.
124 . The topical composition of claim 1 , wherein the carboxylate ester is selected from the group consisting of isopropyl myristate, medium-chain triglycerides, diisopropyl adipate, ethyl acetate, triacetin, dimethyl succinate, propyl acetate, and combinations thereof.
125 . The topical composition of claim 1 , wherein the monohydric aliphatic alcohol is selected from the group consisting of ethanol, isopropanol, propyl alcohol, tert-butyl alcohol, and combinations thereof.