IP Library › Granted Patent US 12,319,672

Granted Patent B2

US 12,319,672 · App. 17/638,799 · Granted Jun 3, 2025

Alpha-D-galactopyranoside derivatives

Inventors: Martin Bolli (Allschwil, CH); John Gatfield (Allschwil, CH); Corinna Grisostomi (Allschwil, CH); Lubos Remen (Allschwil, CH); Christoph Sager (Allschwil, CH); Cornelia Zumbrunn (Allschwil, CH)

Assignee: IDORSIA PHARMACEUTICALS LTD

C07D405/14 C07D413/14 C07D417/14 C07H19/12

View Patent ↗

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US 12,319,672
App. No.: 17/638,799
Granted: Jun 3, 2025
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

The present invention relates to compounds of Formula (I) wherein Ar 1 , R 1 and R 2 are as described in the description, and A is 4,5-dihydroisoxazole-3,5-diyl, imidazolidin-4-one-1,3-diyl, oxazol-2-one-3,5-diyl and oxazolidine-2-one-3,5-diyl, 1,2,3-triazole-1,4-diyl, isoxazole-3,5-diyl, imidazole-1, 4-diyl, and isothiazole-3,5-diyl; and their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

Claims (518)

1. A compound of formula (I)

wherein

Ar 1 represents

aryl which is unsubstituted, or mono-, di-, tri-, tetra-, or penta-substituted, wherein the substituents are independently selected from halogen, methyl, cyano, methoxy, trifluoromethyl, trifluoromethoxy, and ethynyl;

5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl independently is unsubstituted, mono- or di-substituted, wherein the substituents are independently selected from halogen, methyl, cyano, and methoxy; or

9- or 10-membered heteroaryl, wherein said 9- or 10-membered heteroaryl independently is unsubstituted, or mono-substituted with methyl;

R 1 represents

hydroxy; or

methoxy;

A represents 5-membered heterocycloalkylene or 5-membered heteroarylene; wherein said 5-membered heterocycloalkylene is selected from 4,5-dihydroisoxazole-3,5-diyl, imidazolidin-4-one-1,3-diyl, oxazol-2-one-3,5-diyl and oxazolidine-2-one-3,5-diyl; and said 5-membered heteroarylene is selected from 1,2,3-triazole-1,4-diyl, isoxazole-3,5-diyl, imidazole-1,4-diyl, and isothiazole-3,5-diyl; and

R 2 represents

C 1-6 -alkyl;

C 1-6 -alkyl wherein said C 1-6 -alkyl is mono-substituted with C 1-3 -alkoxy, —CO—C 1-4 -alkoxy, —NH 2 or —NH—CO—C 1-4 -alkoxy;

C 1-4 -fluoroalkyl;

C 3-6 -cycloalkyl wherein said C 3-6 -cycloalkyl independently is unsubstituted, mono- or di-substituted wherein the substituents independently are selected from oxo, fluoro, —NH—CO—C 1-4 -alkoxy, C 1-3 -alkyl, C 1-3 -alkoxy, C 1 -fluoroalkyl, cyano, —CH 2 —CN, and —NH—CO—C 1-4 -alkyl wherein said C 1-4 -alkyl is mono-substituted with —NH 2 or —NH—CO—C 1-4 -alkoxy; or said C 3-6 -cycloalkyl together with 1,3-dioxolan-2,2-diyl forms a spiro-bicyclic moiety;

4- to 6-membered heterocycloalkyl wherein said heterocycloalkyl contains one ring oxygen atom and wherein said 4- to 6-membered heterocycloalkyl independently is unsubstituted or mono-substituted with C 1-4 -alkyl;

4- to 6-membered heterocycloalkyl wherein said heterocycloalkyl contains one ring sulfur atom wherein said sulfur atom is unsubstituted or mono-substituted with oxo (=O); or said sulfur atom is disubstituted wherein one substituent is oxo (=O) and the other substituent is selected from oxo (=O), imido (=NH), C 1-3 -alkylimido (=N—C 1-3 -alkyl), 4,4-difluorocyclohexylimido and benzylimido (=N-benzyl);

4- to 7-membered heterocycloalkyl wherein said heterocycloalkyl contains one ring nitrogen atom, wherein said nitrogen atom is unsubstituted or mono-substituted with

C 1-6 -alkyl;

—CO—C 1-6 -alkyl; —CO—C 4-6 -cycloalkyl; —CO—C 1-3 -fluoroalkyl; —CO—C 1-4 -alkoxy; —CO—NH—C 1-4 -alkyl;

—SO 2 —C 1-4 -alkyl; —SO 2 —NH—C 1-4 -alkyl;

—CH 2 —C 3-6 -cycloalkyl;

—CO—C 1-6 -alkyl wherein the C 1-6 -alkyl is mono-substituted with amino;

—CH 2 -oxetanyl;

thiazol-2-yl; oxazol-2-yl; benzo[d]thiazol-2-yl;

—CO-benzyloxy;

—CO—NH 2 ; —CO—NH—C 3-6 -cycloalkyl;

—CO—NR N31 R N32 wherein R N31 and R N32 both independently represent C 1-3 -alkyl;

—CO—NR N41 R N42 wherein R N41 and R N42 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocycloalkyl wherein said 5- or 6-membered heterocycloalkyl independently is unsubstituted or mono-substituted with C 1-3 -alkyl;

—SO—C 1-6 -alkyl;

—SO 2 —C 1-3 -fluoroalkyl; —SO 2 —NH 2 ;

—SO 2 —NR N51 R N52 wherein R N51 and R N52 both independently represent C 1-3 -alkyl;

—SO 2 —NR N61 R N62 wherein R N61 and R N62 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocycloalkyl, wherein said 5- or 6-membered heterocycloalkyl independently is unsubstituted or di-substituted with fluoro;

—SO 2 -phenyl wherein said phenyl is unsubstituted or mono-substituted with methyl;

>—SO(NH)—C 1-6 -alkyl; or —SO(N—C 1-3 -alkyl)-C 1-6 -alkyl;

and wherein said 4- to 7-membered heterocycloalkyl carries no further substituent in addition to said substituent on the ring nitrogen atom, or carries one further substituent which is C 1-4 -alkyl (wherein it is understood that such C 1-4 -alkyl is attached to a ring carbon atom);

wherein R N71 represents hydrogen or —CO—C 1-4 -alkoxy;

cyclopentenyl;

L-OH, wherein L represents

C 1-6 -alkylene;

chloro-C 2-6 -alkylene;

1-phenyl-ethan-1,1-diyl or 1-(2-fluorophenyl)-ethan-1,1-diyl;

(cyclopropyl)-(pyridin-2-yl)-methylene;

C 4-6 -cycloalkylene wherein said C 4-6 -cycloalkylene independently is unsubstituted, mono- or di-substituted wherein the substituents independently are methyl, fluoro, or —CO—R O2 wherein R O2 represents hydroxy or C 1-4 -alkoxy;

cyclopropylene-(CH 2 ) n —* wherein n represents the integer 0 or 1, and wherein the asterisk indicates the bond which is connected to the —OH group;

4- to 7-membered heterocycloalkylene wherein said heterocycloalkylene contains one ring oxygen atom; or

4- to 7-membered heterocycloalkylene wherein said heterocycloalkylene contains one ring nitrogen atom, wherein said nitrogen atom is unsubstituted or mono-substituted with —CO—C 1-4 -alkyl, or —CO—C 1-4 -alkoxy;

5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl independently is unsubstituted or mono-substituted, wherein the substituents independently are C 1-4 -alkyl, C 1-3 -fluoroalkyl, halogen, C 1-4 -alkoxy, or C 1-4 -fluoroalkoxy;

2-oxo-1,2-dihydropyridin-4-yl, 6-oxo-1,6-dihydropyridin-3-yl, or 1-methyl-2-oxo-1,2-dihydropyridin-4-yl;

wherein m and p independently represent the integer 1 or 2; and R N81 represents hydrogen or C 1-4 -alkyl;

C 0-3 -alkylene-phenyl; wherein the phenyl independently is unsubstituted, mono-, di-, or tri-substituted, wherein the substituents independently are C 1-4 -alkyl, C 1-3 -fluoroalkyl, halogen, hydroxy, C 1-4 -alkoxy, or C 1-4 -fluoroalkoxy;

9-membered heteroaryl;

wherein R N91 represents hydrogen or —CO—C 1-4 -alkoxy;

or R 2 represents a group of the structure (R 2-B ):

wherein ring (B) represents a non-aromatic 5-membered ring fused to the phenyl group, wherein ring (B) comprises two heteroatoms independently selected from nitrogen and oxygen; wherein said ring (B) independently is mono- or di-substituted, wherein one of said substituents is oxo, and the other substituent, if present, is C 1-3 -alkyl;

or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1 , wherein Ar 1 represents phenyl which is mono-, di- or tri-substituted, wherein the substituents are independently selected from halogen, methyl, cyano, methoxy, trifluoromethyl, and ethynyl;

wherein at least one of said substituents is attached in a meta- and/or in para-position of said phenyl;

or a pharmaceutically acceptable salt thereof.

3. A compound according to claim 2 , wherein at least one of said substituents is attached in a meta-position of said phenyl and the substituent is halogen;

or a pharmaceutically acceptable salt thereof.

4. A compound according to claim 2 , wherein at least one of said substituents is attached in para-position of said phenyl and the substituent is selected from halogen, methyl, cyano, methoxy, trifluoromethyl, and ethynyl;

or a pharmaceutically acceptable salt thereof.

5. A compound according to claim 1 , wherein Ar 1 represents a phenyl group of the structure

wherein

R m2 represents halogen; and

R p represents hydrogen, halogen, methyl, cyano, or methoxy;

or a pharmaceutically acceptable salt thereof.

6. A compound according to claim 1 , wherein Ar 1 represents

B or a pharmaceutically acceptable salt thereof.

7. A compound according to claim 1 , wherein R 1 represents methoxy;

or a pharmaceutically acceptable salt thereof.

8. A compound according to claim 1 , wherein A represents 1,2,3-triazole-1,4-diyl or isoxazole-3,5-diyl; or a pharmaceutically acceptable salt thereof.

9. A compound according to claim 1 , wherein R 2 represents

C 1-6 -alkyl;

C 1-6 -alkyl wherein said C 1-6 -alkyl is mono-substituted with C 1-3 -alkoxy, —CO—C 1-4 -alkoxy, —NH 2 or —NH—CO—C 1-4 -alkoxy;

C 1-4 -fluoroalkyl;

4- to 6-membered heterocycloalkyl wherein said heterocycloalkyl contains one ring nitrogen atom, wherein said nitrogen atom is unsubstituted or mono-substituted with

C 1-6 -alkyl;

—CO—C 1-6 -alkyl; —CO—C 4-6 -cycloalkyl; —CO—C 1-3 -fluoroalkyl; —CO—C 1-4 -alkoxy; —CO—NH—C 1-4 -alkyl;

—SO 2 —C 1-4 -alkyl;

—CH 2 —C 3-6 -cycloalkyl;

thiazol-2-yl; oxazol-2-yl; benzo[d]thiazol-2-yl;

—CO-benzyloxy;

—CO—NH—C 3-6 -cycloalkyl;

—CO—NR N31 R N32 wherein R N31 and R N32 both independently represent C 1-3 -alkyl;

—SO—C 1-6 -alkyl;

—SO 2 —C 1-3 -alkyl;

—SO 2 —NR N51 R N52 wherein R N51 and R N52 both independently represent C 1-3 -alkyl;

—SO 2 -phenyl wherein said phenyl is mono-substituted with methyl;

—SO(NH)—C 1-6 -alkyl; or —SO(N—C 1-3 -alkyl)-C 1-6 -alkyl;

and wherein said 4- to 6-membered heterocycloalkyl carries no further substituent in addition to said substituent on the ring nitrogen atom, or carries one further substituent which is C 1-4 -alkyl (wherein it is understood that such C 1-4 -alkyl is attached to a ring carbon atom);

L-OH, wherein L represents

C 1-6 -alkylene;

chloro-C 2-6 -alkylene;

1-phenyl-ethan-1,1-diyl or 1-(2-fluorophenyl)-ethan-1,1-diyl;

C 4-6 -cycloalkylene wherein said C 4-6 -cycloalkylene independently is unsubstituted, or di-substituted wherein the substituents independently are methyl, or fluoro;

cyclopropylene-(CH 2 ) n —* wherein n represents the integer 0 or 1, and wherein the asterisk indicates the bond which is connected to the —OH group;

4- to 6-membered heterocycloalkylene wherein said heterocycloalkylene contains one ring oxygen atom; or

4- to 6-membered heterocycloalkylene wherein said heterocycloalkylene contains one ring nitrogen atom, wherein said nitrogen atom is unsubstituted or mono-substituted with —CO—C 1-4 -alkyl, or —CO—C 1-4 -alkoxy;

2-oxo-1,2-dihydropyridin-4-yl, 6-oxo-1,6-dihydropyridin-3-yl, or 1-methyl-2-oxo-1,2-dihydropyridin-4-yl;

wherein m and p independently represent the integer 1 or 2; and R N81 represents hydrogen or C 1-4 -alkyl;

—CH(CH 3 )-phenyl);

wherein R N91 represents hydrogen or —CO—C 1-4 -alkoxy;

or R 2 represents a group of the structure (R 2-B ):

or a pharmaceutically acceptable salt thereof.

10. A compound according to claim 1 ; wherein R 2 represents

C 1-6 -alkyl;

C 1-6 -alkyl wherein said C 1-6 -alkyl is mono-substituted with C 1-3 -alkoxy;

C 1-4 -fluoroalkyl; or

L-OH, wherein L represents

C 1-6 -alkylene;

C 4-6 -cycloalkylene wherein said C 4-6 -cycloalkylene independently is unsubstituted; or

cyclopropylene-(CH 2 ) n —* wherein n represents the integer 0 or 1, and wherein the asterisk indicates the bond which is connected to the —OH group;

or a pharmaceutically acceptable salt thereof.

11. A compound according to claim 1 , wherein R 2 represents

C 1-6 -alkyl;

cyclobutyl, or cyclopentyl;

cyclohexyl which is mono- or di-substituted wherein the substituents independently are oxo, fluoro, or —NH—CO—C 1-4 -alkoxy;

4- to 6-membered heterocycloalkyl wherein said heterocycloalkyl contains one ring oxygen atom;

4- to 7-membered heterocycloalkyl wherein said heterocycloalkyl contains one ring nitrogen atom, wherein said nitrogen atom is unsubstituted or mono-substituted with C 1-6 -alkyl, —CO—C 1-6 -alkyl, —CO—C 4-6 -cycloalkyl, —CO—C 1-3 -fluoroalkyl, —CO—C 1-4 -alkoxy, —CO—NH—C 1-4 -alkyl, —SO 2 —C 1-4 -alkyl, —SO 2 —NH—C 1-4 -alkyl, —CH 2 —C 3-6 -cycloalkyl, —CO—C 1-6 -alkyl wherein the C 1-6 -alkyl is mono-substituted with amino, —CH 2 -oxetanyl, thiazol-2-yl, oxazol-2-yl, or benzo[d]thiazol-2-yl;

L-OH, wherein L represents

C 4-6 -cycloalkylene wherein said C 4-6 -cycloalkylene independently is unsubstituted or mono- or di-substituted wherein the substituents independently are methyl, or fluoro;

4- to 7-membered heterocycloalkylene wherein said heterocycloalkylene contains one ring oxygen atom; or

or R 2 represents a group of the structure (R 2-B ):

or a pharmaceutically acceptable salt thereof.

12. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

13. A method for the treatment of an indication selected from fibrosis of organs; liver diseases and disorders; cardiovascular diseases and disorders; cell proliferative diseases and cancers; inflammatory and autoimmune diseases and disorders; gastrointestinal tract diseases and disorders; pancreatic diseases and disorders; abnormal angiogenesis-associated diseases and disorders; brain-associated diseases and disorders; neuropathic pain and peripheral neuropathy; ocular diseases and disorders; acute kidney injury and chronic kidney disease; interstitial lung diseases and disorders; and transplant rejection; comprising administering to a subject in a need thereof an effective amount of a compound according to claim 1 , or of a pharmaceutically acceptable salt thereof.

14. A compound, wherein said compound is:

6-((RS)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)benzo[d]oxazol-2(3H)-one;

6-((RS)-5-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol- 1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)benzo[d]oxazol-2(3H)-one;

6-((S)-5-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)benzo[d]oxazol-2(3H)-one;

tert-butyl 4-(3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((S)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

(2R,3R,4R,5R,6R)-2-((5-(tert-butyl)isoxazol-3-yl)methyl)-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

tert-butyl (RS)-3-(3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

(2R,3R,4R,5R,6R)-2-(hydroxymethyl)-6-((5-(tetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

tert-butyl 4-(3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)-4-hydroxypiperidine-1-carboxylate;

tert-butyl 4-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(tetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-cyclopentylisoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(1-hydroxycyclohexyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-cyclobutylisoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(4,4-difluorocyclohexyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

tert-butyl ((1R,4R)-4-(3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)cyclohexyl)carbamate;

tert-butyl ((1S,4S)-4-(3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)cyclohexyl)carbamate;

(2R,3R,4R,5R,6R)-2-(hydroxymethyl)-6-((5-(1-(oxazol-2-yl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4R,5R,6R)-2-((5-(1-(benzo[d]thiazol-2-yl)piperidin-4-yl)isoxazol-3-yl)methyl)-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4R,5R,6R)-2-(hydroxymethyl)-6-((5-(1-(thiazol-2-yl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

5-((RS)-5-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol- 1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)pyridin-2(1H)-one;

4-((S)-5-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)pyridin-2(1H)-one;

4-((RS)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)pyridin-2(1H)-one;

4-((S)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)pyridin-2(1H)-one;

4-(3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)cyclohexan-1-one;

(2R,3R,4R,5R,6R)-2-((5-(4-hydroxycyclohexyl)isoxazol-3-yl)methyl)-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4R,5R,6R)-2-((5-((1R,4R)-4-hydroxycyclohexyl)isoxazol-3-yl)methyl)-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4R,5R,6R)-2-(hydroxymethyl)-6-(((RS)-3-(piperidin-4-yl)-4,5-dihydroisoxazol-5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

1-(4-((RS)-5-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidin-1-yl)ethan-1-one;

1-(4-((RS)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H- 1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidin-1-yl)ethan-1-one;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-(((S)-3-(piperidin-4-yl)-4,5-dihydroisoxazol-5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4R,5R,6R)-2-(hydroxymethyl)-6-((5-(piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

1-(4-((S)-5-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidin-1-yl)ethan-1-one;

1-(4-((S)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H- 1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidin-1-yl)ethan-1-one;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

1-(4-(3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3- triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-((RS)-3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-((S)-3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

ethyl 4-(3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol- 1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

4-(3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)-N-ethylpiperidine-1-carboxamide;

(2R,3R,4R,5R,6R)-2-(hydroxymethyl)-6-((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4R,5R,6R)-2-(hydroxymethyl)-6-((5-(1-methylpiperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

1-(4-(3-(((2R,3R,4R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3- triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)-2,2-dimethylpropan-1-one;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

methyl 4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

1-(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)-2-methylpropan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)-2,2-dimethylpropan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)butan-1-one;

N-ethyl-4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxamide;

4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)-N-isopropylpiperidine-1-carboxamide;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-methylpiperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-((5-(1-isobutylpiperidin-4-yl)isoxazol-3-yl)methyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(1-(3,3-dimethylbutyl)piperidin-4-yl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(1-(cyclopropylmethyl)piperidin-4-yl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(propylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-((5-(1-(isopropylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

1-(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)-3-methylbutan-1-one;

cyclopentyl(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)methanone;

cyclobutyl(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)methanone;

3,3,3-trifluoro-1-(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)propan-1-one;

N-(tert-butyl)-4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxamide;

(RS)-1-(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H- 1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)-2-methylbutan-1-one;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

1-(4-(1-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)piperidin-1-yl)ethan-1-one;

tert-butyl 4-(4-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate;

1-(4-(4-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)piperidin-1-yl)ethan-1-one;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((1-(1-(methylsulfonyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

N-(tert-butyl)-4-(4-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxamide;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((1-(1-(propylsulfonyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-((1-(1-(isopropylsulfonyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

tert-butyl 4-((RS)-5-(((2R,3R,4R,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4R,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4R,5R,6R)-4-(4-(3,4-dichlorophenyl)-1H-1,2,3-triazol-1-yl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4R,5R,6R)-4-(4-(3,4-difluoro-5-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4R,5R,6R)-4-(4-(4-chloro-3-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

(RS)-5-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)piperidin-2-one;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5- hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)-1-methylpyridin-2(1H)-one;

(2R,3R,4S,5R,6R)-6-((3-cyclohexylisoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

tert-butyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

tert-butyl 4-(5-(((2R,3R,4S,5R,6R)-4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6- (hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-(5-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-(5-(((2R,3R,4S,5R,6R)-4-(4-(4-bromo-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-(5-(((2R,3R,4S,5R,6R)-4-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-6-((5-(4-bromothiazol-2-yl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-(((S)-5-cyclohexyl-4,5-dihydroisoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

tert-butyl (4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)bicyclo[2.2.2]octan-1-yl)carbamate;

(2R,3R,4S,5R,6R)-6-((5-(4-aminobicyclo[2.2.2]octan-1-yl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol formate;

tert-butyl 4-hydroxy-4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-4-ol formate;

tert-butyl ((1R,4r)-4-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)cyclohexyl)carbamate;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-4-(4-(3,5-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5- hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-4-(4-(3-fluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5- hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5- hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-((S)-1-(N-methylpropan-2-ylsulfonimidoyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-((R)-1-(N-methylpropan-2-ylsulfonimidoyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5- hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5- hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-(((RS)-3-(piperidin-4-yl)-4,5-dihydroisoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol formate;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-(((RS)-3-(piperidin-4-yl)-4,5-dihydroisoxazol-5-yl)methyl)-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol formate;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5- hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-(((RS)-3-(piperidin-4-yl)-4,5-dihydroisoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol formate;

(1R,4r)-4-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)-1-(isopropylimino)hexahydro-116-thiopyran 1-oxide;

(1S,4s)-4-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)-1-(isopropylimino)hexahydro-116-thiopyran 1-oxide;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-4-(4-(3,5-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(3-fluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6- ((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6- ((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-5-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6- ((5-(1-(methylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

1-(4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3,5-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy- 6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3-fluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy- 6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy- 6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy- 6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

1-(4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3-chloro-5-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-((5-cyclohexylisoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-cyclohexylisoxazol-3-yl)methyl)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol- 1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(3,5-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(tetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(3-fluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6- ((5-(tetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(tetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(tetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6- ((5-(tetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(tetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(tetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(tetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(3,5-difluoro-4-methylphenyl)-1H-1,2,3- triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(3-fluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3- triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3- triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3- triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-((5-(1-(N-isopropylpropan-2-ylsulfonimidoyl)piperidin-4-yl)isoxazol-3-yl)methyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3-chloro-5-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3-fluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3,5-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

(2R,3R,4R,5R,6R)-2-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3- triazol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4S,5R,6R)-6-((3-(tert-butyl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(1-hydroxy-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

ethyl 3-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)-3-methylbutanoate;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methoxycyclopentyl)isoxazol-5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methoxycyclohexyl)isoxazol-5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(3-methyloxetan-3-yl)isoxazol-5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(3-ethyloxetan-3-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(1-fluorocyclopropyl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(1-(difluoromethyl)cyclopropyl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methylcyclopropyl)isoxazol-5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(2-aminopropan-2-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

1-(4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3-chloro-4,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy- 6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)ethan-1-one;

ethyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3-chloro-4,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(3-chloro-4,5-difluorophenyl)-1H-1,2,3- triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-cyclopentylisoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-cyclobutylisoxazol-3-yl)methyl)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol- 1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-cyclobutylisoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-((5-cyclobutylisoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

tert-butyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6- (hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-((5-(2-hydroxypropan-2-yl)isoxazol-3-yl)methyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(1-hydroxycyclohexyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(1-hydroxycyclopentyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-cyclopentylisoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(1-hydroxycyclobutyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-6-((5-(2-hydroxypropan-2-yl)isoxazol-3-yl)methyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-(1-hydroxycyclohexyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-(1-hydroxycyclopentyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-cyclopentylisoxazol-3-yl)methyl)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-(1-hydroxycyclobutyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-6-((5-(2-hydroxypropan-2-yl)isoxazol-3-yl)methyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-((5-(1-hydroxycyclohexyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-((5-(1-hydroxycyclopentyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-((5-cyclopentylisoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-((5-(1-hydroxycyclobutyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(2,5-difluoro-4-methylphenyl)-1H-1,2,3- triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

tert-butyl 4-(3-(((2R,3R,4S,5R,6R)-4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6- (hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-6-((3-(tert-butyl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methylcyclopropyl)isoxazol-5-yl)methyl)-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(3-methyloxetan-3-yl)isoxazol-5-yl)methyl)-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(1-hydroxy-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(tert-butyl)isoxazol-5-yl)methyl)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3- triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methylcyclopropyl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((3-(3-methyloxetan-3-yl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((3-(1-hydroxy-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(tert-butyl)isoxazol-5-yl)methyl)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3- triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methylcyclopropyl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((3-(3-methyloxetan-3-yl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-((3-(1-hydroxy-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(1-chloro-3-hydroxy-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(1-chloro-3-hydroxy-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-4-(4-(2,3- difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-((3-(1-chloro-3- hydroxy-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-(((RS)-3-(tert-butyl)-4,5-dihydroisoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-(((RS)-3-(tert-butyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

4-(1-((2R,3R,4S,5R,6R)-2-((5-(tert-butyl)isoxazol-3-yl)methyl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-4-yl)-2,3-difluorobenzonitrile;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(4-methyltetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(4-methyltetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(4-methyltetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(4-methyltetrahydro-2H-pyran-4-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-methylcyclopentyl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-methylcyclopentyl)isoxazol-3-yl)methyl)-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-methylcyclopentyl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-methylcyclopentyl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

1-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)cyclopentane-1-carbonitrile;

1-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)cyclopentane-1-carbonitrile;

1-(3-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)cyclopentane-1-carbonitrile;

1-(3-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)cyclopentane-1-carbonitrile;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-(((RS)-3-(1-hydroxy-2-methylpropan-2-yl)-4,5-dihydroisoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(4-methyltetrahydro-2H-pyran-4-yl)isoxazol-5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(4-methyltetrahydro-2H-pyran-4-yl)isoxazol-5-yl)methyl)-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((3-(4-methyltetrahydro-2H-pyran-4-yl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((3-(4-methyltetrahydro-2H-pyran-4-yl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methylcyclopentyl)isoxazol-5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methylcyclopentyl)isoxazol-5-yl)methyl)-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methylcyclopentyl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methylcyclopentyl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol;

1-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)cyclopentane-1-carbonitrile;

1-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)cyclopentane-1-carbonitrile;

1-(5-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)cyclopentane-1-carbonitrile;

1-(5-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)cyclopentane-1-carbonitrile;

(2R,3R,4R,5R,6R)-2-((3-(tert-butyl)isoxazol-5-yl)methyl)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3- triazol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4S,5R,6R)-6-((3-(1,1-difluoro-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-((3-isopropylisoxazol-5-yl)methyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((3-(1-hydroxycyclopentyl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

2-(1-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)cyclopropyl)acetonitrile;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methoxy-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

tert-butyl (2-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)-2-methylpropyl)carbamate;

(2R,3R,4S,5R,6R)-6-((3-(1-amino-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-((RS)-1-hydroxy-1-phenylethyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-(1-hydroxycyclopropyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((5-(3-methyloxetan-3-yl)isoxazol-3-yl)methyl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-6-((5-(1-(hydroxymethyl)cyclopropyl)isoxazol-3-yl)methyl)-5-methoxytetrahydro-2H-pyran-3-ol;

ethyl 4-(5-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)-4-methylpiperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((3-(1-hydroxycyclopentyl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((3-(2-ethoxypropan-2-yl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxy-6-((3-(1-methoxy-2-methylpropan-2-yl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3-ol;

tert-butyl (2-(5-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5- hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)-2-methylpropyl)carbamate;

2-(1-(5-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy- 6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)cyclopropyl)acetonitrile;

(2R,3R,4R,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-6-((3-(1-methylcyclopropyl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4R,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-((3-(1-hydroxy-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4R,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-6-((3-(3-methyloxetan-3-yl)isoxazol-5-yl)methyl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4S,5R,6R)-6-((3-(1-amino-2-methylpropan-2-yl)isoxazol-5-yl)methyl)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(RS)-5-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)azepan-2-one;

4-(1-((2R,3R,4S,5R,6R)-2-((3-(tert-butyl)isoxazol-5-yl)methyl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-4-yl)-2,3-difluorobenzonitrile;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-((R)-1-hydroxy-1-phenylethyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-((1RS,2RS)-2-hydroxycyclobutyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-2-((5-((1RS,2RS)-2-hydroxycyclopentyl)isoxazol-3-yl)methyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl acetate;

(RS)-5-(5-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)-1-methylazepan-2-one;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-((1S,2S)-2-hydroxycyclobutyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-((1R,2R)-2-hydroxycyclobutyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(RS)-5-(5-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)azepan-2-one;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-((1S,2R)-2-hydroxycyclopropyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((5-((1R,2R)-2-hydroxycyclopropyl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(2,3-difluoro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(RS)-4-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)-1-methylpiperidin-2-one;

(RS)-4-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)piperidin-2-one;

(RS)-4-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)pyrrolidin-2-one;

tert-butyl 4-((RS)-5-(((2R,3R,4R,5R,6R)-4-(4-(4-chloro-2,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl 4-((RS)-5-(((2R,3R,4R,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydroisoxazol-3-yl)piperidine-1-carboxylate;

tert-butyl ((S)-1-(((1R,4S)-4-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)cyclohexyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate;

(S)-2-amino-N-((1R,4S)-4-(5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-3-yl)cyclohexyl)-3-methylbutanamide;

(2R,3R,4S,5R,6R)-6-((5-(tert-butyl)isoxazol-3-yl)methyl)-4-(4-(4-ethynyl-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4R,5R,6R)-2-((3-(tert-butyl)isoxazol-5-yl)methyl)-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4R,5R,6R)-2-((3-(tert-butyl)isoxazol-5-yl)methyl)-6-(hydroxymethyl)-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4R,5R,6R)-2-((3-(tert-butyl)isoxazol-5-yl)methyl)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3- triazol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-6-((3-(1-hydroxycyclobutyl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-6-((3-(1-hydroxycyclobutyl)isoxazol-5-yl)methyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-((3-(2-hydroxypropan-2-yl)isoxazol-5-yl)methyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-6-((3-(2-hydroxypropan-2-yl)isoxazol-5-yl)methyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-6-((3-(2-hydroxypropan-2-yl)isoxazol-5-yl)methyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(1-((S)-tert-butylsulfinyl)piperidin-4-yl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(2-methylpropan-2-ylsulfonimidoyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(N-methylpropan-2-ylsulfonimidoyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)-N,N-dimethylpiperidine-1-sulfonamide;

N-cyclopropyl-4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidine-1-carboxamide;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-(((S)-3-(1-(isopropylsulfonyl)piperidin-4-yl)-4,5-dihydroisoxazol-5-yl)methyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(morpholinosulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(piperidin-1-ylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(1-(pyrrolidin-1-ylsulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((5-(1-((4,4-difluoropiperidin-1-yl)sulfonyl)piperidin-4-yl)isoxazol-3-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)piperidin-1-yl)(piperidin-1-yl)methanone;

N-ethyl-4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)-N-methylpiperidine-1-carboxamide;

4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isoxazol-5-yl)-N,N-dimethylpiperidine-1-carboxamide;

benzyl 4-(4-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((1-(tetrahydro-2H-thiopyran-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

4-(4-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-thiopyran 1-oxide;

(2R,3R,4S,5R,6R)-6-((1-(1-((S)-tert-butylsulfinyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

benzyl 4-(1-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((1-(1-(2-methylpropan-2-ylsulfonimidoyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-((4-(1-(isopropylsulfonyl)piperidin-4-yl)-1H-1,2,3-triazol-1-yl)methyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((4-(1-tosylpiperidin-4-yl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

1-(ethylimino)-4-(4-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)hexahydro-116-thiopyran 1-oxide;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((4-(1-(N-methylpropan-2-ylsulfonimidoyl)piperidin-4-yl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

4-(1-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)-N,N-dimethylpiperidine-1-sulfonamide;

N-(tert-butyl)-4-(1-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)piperidine-1-carboxamide;

1-(benzylimino)-4-(4-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)hexahydro-116-thiopyran 1-oxide;

(2R,3R,4S,5R,6R)-6-((1-cyclohexyl-1H-1,2,3-triazol-4-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

N-cyclopropyl-4-(1-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)piperidine-1-carboxamide;

1-((4,4-difluorocyclohexyl)imino)-4-(4-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)hexahydro-116-thiopyran 1-oxide;

benzyl 4-(4-(((2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate;

benzyl 4-(4-(((2R,3R,4S,5R,6R)-4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6- (hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate;

benzyl 4-(4-(((2R,3R,4S,5R,6R)-4-(4-(4-bromo-3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate;

benzyl 4-(4-(((2R,3R,4S,5R,6R)-4-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-6-((4-(tert-butyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

ethyl 4-(1-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((4-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-((4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl)methyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((4-cyclopentyl-1H-1,2,3-triazol-1-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((4-(1-methylcyclopentyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((4-(4-methyltetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((4-(tert-butyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((4-(tert-butyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

(RS)-3-(1-acetylpiperidin-4-yl)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)oxazolidin-2-one;

(RS)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-3-(1-(methylsulfonyl)piperidin-4-yl)oxazolidin-2-one;

(S)-3-(1-acetylpiperidin-4-yl)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)oxazolidin-2-one;

(S)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-3-(1-(methylsulfonyl)piperidin-4-yl)oxazolidin-2-one;

(R)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-3-(1-(methylsulfonyl)piperidin-4-yl)oxazolidin-2-one;

(RS)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-3-(1-isobutyrylpiperidin-4-yl)oxazolidin-2-one;

4-((RS)_5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-2-oxooxazolidin-3-yl)-N,N-dimethylpiperidine-1-carboxamide;

(S)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-3-(1-isobutyrylpiperidin-4-yl)oxazolidin-2-one;

tert-butyl 4-((R)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-2-oxooxazolidin-3-yl)piperidine-1-carboxylate;

(RS)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-3-(tetrahydro-2H-pyran-4-yl)oxazolidin-2-one;

(RS)-3-(1-(3,3-dimethylbutanoyl)piperidin-4-yl)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)oxazolidin-2-one;

(RS)-3-(1-(tert-butylsulfonyl)piperidin-4-yl)-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)oxazolidin-2-one;

(RS)-3-cyclohexyl-5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)oxazolidin-2-one;

tert-butyl 4-((RS)-3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-2-oxooxazolidin-5-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)isothiazol-5-yl)piperidine-1-carboxylate;

(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-5-methoxy-6-((5-(piperidin-4-yl)isothiazol-3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

(2R,3R,4S,5R,6R)-6-((4-(tert-butyl)-1H-imidazol-1-yl)methyl)-2-(hydroxymethyl)-5-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3-ol;

5-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-3-phenyloxazol-2(3H)-one;

3-cyclohexyl-1-(((2R,3R,4S,5R,6R)-4-(4-(2,3-difluoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy- 6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)methyl)imidazolidin-4-one;

1-(1-acetylpiperidin-4-yl)-3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)imidazolidin-4-one;

3-(1-acetylpiperidin-4-yl)-1-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)imidazolidin-4-one;

3-cyclohexyl-1-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)imidazolidin-4-one;

1-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-3-(tetrahydro-2H-pyran-4-yl)imidazolidin-4-one; or

ethyl 4-(3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-yl)methyl)-5-oxoimidazolidin-1-yl) piperidine-1-carboxylate;

or a pharmaceutically acceptable salt thereof.

15. A pharmaceutical composition comprising a compound according to claim 14 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

16. A method for the treatment of an indication selected from fibrosis of organs; liver diseases and disorders; cardiovascular diseases and disorders; cell proliferative diseases and cancers; inflammatory and autoimmune diseases and disorders; gastrointestinal tract diseases and disorders; pancreatic diseases and disorders; abnormal angiogenesis-associated diseases and disorders; brain-associated diseases and disorders; neuropathic pain and peripheral neuropathy; ocular diseases and disorders; acute kidney injury and chronic kidney disease; interstitial lung diseases and disorders; and transplant rejection; comprising administering to a subject in a need thereof an effective amount of a compound according to claim 14 , or of a pharmaceutically acceptable salt thereof.

17. A compound, wherein said compound is (2R,3R,4S,5R,6R)-6-((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol;

or a pharmaceutically acceptable salt thereof.

18. A pharmaceutical composition comprising the compound according to claim 17 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

19. A method for the treatment of an indication selected from fibrosis of organs; liver diseases and disorders; cardiovascular diseases and disorders; cell proliferative diseases and cancers; inflammatory and autoimmune diseases and disorders; gastrointestinal tract diseases and disorders; pancreatic diseases and disorders; abnormal angiogenesis-associated diseases and disorders; brain-associated diseases and disorders; neuropathic pain and peripheral neuropathy; ocular diseases and disorders; acute kidney injury and chronic kidney disease; interstitial lung diseases and disorders; and transplant rejection; comprising administering to a subject in a need thereof an effective amount of the compound according to claim 1 , or of a pharmaceutically acceptable salt thereof.

20. The compound according to claim 17 , wherein said compound is (2R,3R,4S,5R,6R)-6-((1-(tert-butyl)-1H-1,2,3-triazol-4-yl) methyl)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol.

21. A pharmaceutical composition comprising the compound according to claim 20 and a pharmaceutically acceptable carrier.

22. The compound according to claim 17 , wherein said compound is a pharmaceutically acceptable salt of (2R,3R,4S,5R,6R)-6-((1-(tert-butyl)-1H-1,2,3-triazol-4-yl) methyl)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3-ol.

23. A pharmaceutical composition comprising the compound according to claim 22 and a pharmaceutically acceptable carrier.

Assignments (2)

PATENT SECURITY AGREEMENT Recorded Jun 25, 2026

From: IDORSIA PHARMACEUTICALS LTD

To: BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT

Reel/Frame 076038/0461 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 27, 2022

From: BOLLI, MARTIN; GATFIELD, JOHN; GRISOSTOMI, CORINNA; REMEN, LUBOS; SAGER, CHRISTOPH; ZUMBRUNN, CORNELIA

To: IDORSIA PHARMACEUTICALS LTD

Reel/Frame 060444/0230 →

Priority Claims (1)

WO PCT/EP2019/073063 · Aug 29, 2019 · international

Continuity (1)

Related Publication 20220281855A1 · Sep 8, 2022

References Cited (91)

US 20140099319A1 · Traber · 2014 [cited by applicant]

US 20230295182A1 · Bolli et al. · 2023 [cited by applicant]

US 20230348442A1 · Bolli et al. · 2023 [cited by applicant]

US 20240109930A1 · Bolli et al. · 2024 [cited by applicant]

US 20240124427A1 · Bolli et al. · 2024 [cited by applicant]

WO WO02057284A1 · 2002 [cited by applicant]

WO WO2005113568A1 · 2005 [cited by applicant]

WO WO2005113569A1 · 2005 [cited by applicant]

WO WO2014067986A1 · 2014 [cited by applicant]

WO WO2014078655A1 · 2014 [cited by applicant]

WO WO2016120403A1 · 2016 [cited by examiner]

WO WO2017007689A1 · 2017 [cited by applicant]

WO WO2018011094A1 · 2018 [cited by applicant]

WO WO2018209255A1 · 2018 [cited by applicant]

WO WO2018209276A1 · 2018 [cited by applicant]

WO WO2019067702A1 · 2019 [cited by applicant]

WO WO2019067702A9 · 2019 [cited by applicant]

WO WO2019075045A1 · 2019 [cited by applicant]

WO WO2019089080A1 · 2019 [cited by applicant]

WO WO2020078807A1 · 2020 [cited by applicant]

WO WO2020078808A1 · 2020 [cited by applicant]

WO WO2020104335A1 · 2020 [cited by applicant]

WO WO2020210308A1 · 2020 [cited by applicant]

WO WO2021001528A1 · 2021 [cited by applicant]

WO WO2021004940A1 · 2021 [cited by applicant]

WO WO2021028323A1 · 2021 [cited by applicant]

WO WO2021028336A1 · 2021 [cited by applicant]

WO WO2021028570A1 · 2021 [cited by applicant]

WO WO2022073969A1 · 2022 [cited by applicant]

WO WO2022090544A1 · 2022 [cited by applicant]

WO WO2022171594A1 · 2022 [cited by applicant]

WO WO2022184755A1 · 2022 [cited by applicant]

U.S. Appl. No. 18/248,007, filed Apr. 5, 2023 (371(c) Date), Bolli et al. [cited by applicant]

U.S. Appl. No. 18/251,273, filed May 1, 2023 (371(c) Date), Bolli et al. [cited by applicant]

U.S. Appl. No. 18/264,751, filed Aug. 8, 2023 (371(c) Date), Bolli et al. [cited by applicant]

U.S. Appl. No. 18/548,833, filed Sep. 1, 2023 (371(c) Date), Bolli et al. [cited by applicant]

U.S. Appl. No. 17/633,895, filed Feb. 8, 2022 (371(c) Date), Bolli et al. [cited by applicant]

U.S. Appl. No. 17/633,941, filed Feb. 8, 2022 (371(c) Date), Bolli et al. [cited by applicant]

U.S. Appl. No. 17/634,512, filed Feb. 10, 2022 (371(c) Date), Bolli et al. [cited by applicant]

Arciniegas, E. et al., “Galectin-1 and Galectin-3 and Their Potential Binding Partners in the Dermal Thickening of Keloid Tissues,” The American Journal of Dermatopathology, 2019, 41 (3), 193-204. [cited by applicant]

Barondes, S. et al., “Galectins: A Family of Animal βGalactoside-Binding Lectins,” Cell, 1994, 76, 597-598. [cited by applicant]

Burguillos, M. et al., “Macroglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation,” Cell Reports, 2015, 10, 1626-1638. [cited by applicant]

Caniglia, J. et al., “A potential role for Galectin-3 inhibitors in the treatment of COVID-19,” PeerJ, 2020, 8:e9392, 10 pages, doi:10.7717/peerj.9392. [cited by applicant]

Chen, W-S. et al., “Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis,” Investigative Ophthalmology & Visual Science, 2017, 58 (1), 9-20. [cited by applicant]

Chen, Y-J. et al., “Galectin-3 Enhances Avian H5N1 Influenza A Virus-Induced Pulmonary Inflammation by Promoting NLRP3 Inflammasome Activation,” The American Journal of Pathology, 2018, 188 (4), 1031-1042. [cited by applicant]

Chiariotti, L. et al., “Galectin genes: Regulation of expression,” Glycoconjugate Journal, 2004, 19, 441-449. [cited by applicant]

Dang, Z. et al., “Tubular Atrophy and Interstitial Fibrosis After Renal Transplantation Is Dependent on Galectin-3,” Transplantation, 2012, 93 (5), 477-484. [cited by applicant]

Deroo, E. et al., “The role of galectin-3 and galectin-3-binding protein in venous thrombosis,” Blood, 2015, 125 (11), 1813-1821. [cited by applicant]

Falcone, C. et al., “Galectin-3 Plasma Levels and Coronary Artery Disease: A New Possible Biomarker of Acute Coronary Syndrome,” International Journal of Immunopathology and Pharmacology, 2011, 24 (4), 905-913. [cited by applicant]

Farhad, M. et al., “The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment,” OncoImmunology, 2018, 7 (6), e 1434467, 8 pages, https://doi.org/10.1080/2162402X.2018.1434… [cited by applicant]

Galectin Therapeutics, “Combination Immunotherapy with Galectin-3 Inhibitor GR-MD-02 Enhances Effects in Pre-clinical Models and Early Results of Phase 1 Clinical Trials,” Press Release, dated 2017, 3 pages. [cited by applicant]

Galectin Therapeutics, “Galectin Therapeutics Announces Results from Phase 2b NASH-CX Trial,” Bloomberg, Press Release, dated 2017, 5 pages. [cited by applicant]

Galecto Biotech, “Galecto Biotech's Lead Molecule TD139 is Safe, Well Tolerated, with Direct Target Engagement and Biomarker Effects in a Clinical Phase Ib/IIa trial in IPF Patients,” Press Release, dated 2017, 4 pages. [cited by applicant]

Gao, P. et al., “Galectin-3: its role in asthma and potential as an anti-inflammatory target,” Respiratory Research, 2013, 14:136, 9 pages, doi: 10.1186/1465-9921-14-136. [cited by applicant]

Gehlken, C. et al., “Galectin-3 in Heart Failure: An Update of the Last 3 Years,” Heart Failure Clinics, 2018, 14, 75-92. [cited by applicant]

Greene, T. et al., Eds., Protective Groups in Organic Synthesis, Wiley-Interscience, 1999. [cited by applicant]

Guha, P. et al., “Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis,” Proceedings of the National Academy of Sciences, 2013, 110 (13), 5052-5057. [cited by applicant]

Henderson, N. et al., “Galectin-3 regulates myofibroblast activation and hepatic fibrosis,” Proceedings of the National Academy of Sciences, 2006, 103 (13), 5060-5065. [cited by applicant]

Henderson, N. et al., “Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis,” The American Journal of Pathology, 2008, 172 (2), 288-298. [cited by applicant]

Henderson, N. et al., “The regulation of inflammation by galectin-3,” Immunological Reviews, 2009, 230, 160-171. [cited by applicant]

Hsu, D. et al., “Galectin-3 Expression is Induced in Cirrhotic Liver and Hepatocellular Carcinoma,” International Journal of Cancer, 1999, 81, 519-526. [cited by applicant]

Jin, Q-h. et al., “Serum galectin-3: a risk factor for vascular complications in type 2 diabetes mellitus,” Chinese Medical Journal, 2013, 126 (11), 2109-2115. [cited by applicant]

Johannes, L. et al., “Galectins at a glance,” Journal of Cell Science, 2018, 131, jcs208884, 9 pages, doi:10.1242/jcs.208884. [cited by applicant]

Kikuchi, Y. et al., “Galectin-3-positive call infiltration in human diabetic nephropathy,” Nephrology Dialysis Transplantation, 2004, 19 (3), 602-607. [cited by applicant]

Lacina, L. et al., “Glycophenotype of Psoriatic Skin,” Folia Biologica (Praha), 2006, 52, 10-15. [cited by applicant]

Leffler, H. et al., “Introduction to galectins,” Glycoconjugate Journal, 2004, 19, 433-440. [cited by applicant]

Li, P. et al., “Hematopoietic-derived Galectin-3 Causes Cellular and Systemic Insulin Resistance,” HHS Public Access, Author manuscript, available in PMC 2017, 22 pages, face of article states: Published in final edited… [cited by applicant]

Liu, F-T. et al., “Galectins in acute and chronic inflammation,” Annals of the New York Academy of Sciences, 2012, 1253, 80-91. [cited by applicant]

Lowary, T. et al., “Recognition of synthetic O-methyl, epimeric, and amino analogues of the acceptor α-L-Fuc p-(1 → 2)-ß-D-Gal p-OR by the blood-group A and B gene-specified glycosyltransferases,” Carbohydrate Research,… [cited by applicant]

MacKinnon, A et al., “Regulation of Transforming Growth Factor-ß1-driven Lung Fibrosis by Galectin-3,” American Journal of Respiratory and Critical Care Medicine, 2012, 185 (5), 537-546. [cited by applicant]

Mooring, S. et al., “Design and Synthesis of Novel Small-Molecule Inhibitors of the Hypoxia Inducible Factor Pathway,” Journal of Medicinal Chemistry, 2011, 54, 8471-8489. [cited by applicant]

Mukaiyama, T. et al., “The Reactions of Primary Nitroparaffins with Isocyanates,” Journal of the American Chemical Society, 1960, 82, 5339-5342. [cited by applicant]

Nachtigal, M. et al., “Galectin-3 Expression in Human Atherosclerotic Lesions,” American Journal of Pathology, 1998, 152 (5), 1199-1208. [cited by applicant]

Nishi, Y. et al., “Role of Galectin-3 in Human Pulmonary Fibrosis,” Allergology International, 2007, 56 (1), 57-65. [cited by applicant]

Noël, J-C. et al., “Galectin-3 is Overexpressed in Various Forms of Endometriosis,” Applied Immunohistochemistry & Molecular Morphology, 2011, 19 (3), 253-257. [cited by applicant]

Rao, S. et al., “Regulation of Eosinophil Recruitment and Activation by Galectins in Allergic Asthma,” Frontiers in Medicine, 2017, 4:68, 12 pages, doi:10.3389/fmed.2017.00068. [cited by applicant]

Rebholz, C. et al., “Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease,” Kidney International, 2018, 93, 252-259. [cited by applicant]

Remington, The Science and Practice of Pharmacy, 21st Edition, 2005, Part 5, “Pharmaceutical Manufacturing,” published by Lippincott Williams & Wilkins. [cited by applicant]

Ruvolo, P., “Galectin 3 as a guardian of the tumor microenvironment,” Biochimica et Biophysica Acta, 2016, 1863, 427-437. [cited by applicant]

Saegusa J. et al., “Galectin-3 Is Critical for the Development of the Allergic Inflammatory Response in a Mouse Model of Atopic Dermatitis,” The American Journal of Pathology, 2009, 174 (3), 922-931. [cited by applicant]

Sano, H. et al., “Human Galectin-3 Is a Novel Chemoattractant for Monocytes and Macrophages,” The Journal of Immunology, 2000, 165 (4), 2156-2164. [cited by applicant]

Sciacchitano, S. et al., “Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z,” International Journal of Molecular Sciences, 2018, 19, 379, 59 pages, doi:10.3390/ijms19020379. [cited by applicant]

Sharma, U. et al., “Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage,” HHS Public Access, Author manuscript, available in PMC 2019, 17 pages, face of article sta… [cited by applicant]

Stahl, P. et al., Eds., Handbook of Pharmaceutical Salts, Properties, Selection, and Use, Wiley-VCH, 2008. [cited by applicant]

Sundblad, V. et al., “Regulated expression of galectin-3, a multifunctional glycan-binding protein, in haematopoietic and non-haematopoietic tissues,” Histology and Histopathology, 2011, 26, 247-265. [cited by applicant]

Taniguchi, T. et al., “Serum Levels of Galectin-3: Possible Association with Fibrosis, Aberrant Angiogenesis, and Immune Activation in Patients with Systemic Sclerosis,” Journal of Rheumatology, 2012, 39 (3), 539-544. [cited by applicant]

Thandavarayan, R. et al., “14-3-3 protein regulates Askl signaling and protects against diabetic cardiomyopathy,” Biochemical Pharmacology, 2008, 75, 1797-1806. [cited by applicant]

Vuong, L. et al., “An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade,” Cancer Research, 2019, 79 (7), 1480-1492. [cited by applicant]

Witczak, Z. et al., Eds., Click Chemistry in Glycoscience: New Developments and Strategies, 2013, John Wiley & Sons, Inc., Hoboken, New Jersey. [cited by applicant]

Wouters, J. et al., Eds., Pharmaceutical Salts and Co-crystals, RSC Publishing, 2012. [cited by applicant]

Zhong, X. et al., “The role of galectin-3 in heart failure and cardiovascular disease,” Clinical and Experimental Pharmacology and Physiology, 2019, 46, 197-203. [cited by applicant]