IP Library Granted Patent US 12,293,820
Granted Patent B2
US 12,293,820 · App. 17/640,618 · Granted May 6, 2025

Methods and apparatus for determining radioablation treatment

Inventors: Leigh Scott Johnson (Chicago, IL); Patrik Niklaus Kunz (Baden, CH); Andrea Morgan (Seattle, WA); Francesca Attanasi (Baar, CH); Stefan Georg Scheib (Waedenswil, CH); Jonas Honegger (Zurich, CH)
Assignees: VARIAN MEDICAL SYSTEMS, INC.; SIEMENS HEALTHINEERS INTERNATIONAL AG
G16H30/40G06T17/20G06V10/26G06T2210/41
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,293,820
App. No.
17/640,618
Granted
May 6, 2025
Kind
B2
Abstract

Systems and methods for cardiac radioablation treatment planning are disclosed. In some examples, a computing device receives an image volume and a dose matrix data. The computing device generates a first mesh of organ substructures for the organ based on substructure contours for the organ. Further, the computing device generates a second mesh of an isodose volume based on the dose matrix data. The computing device displays the first mesh of the organ substructures and the second mesh of the isodose volume within a same scene. In some examples, the computing device samples a plurality of dosage values, determines representative dosage values for each of a plurality of points along surfaces of a dose matrix, and generates an image for display based on the representative dosage values. In some examples, a segmentation model is generated for display based on the representative dosage values.

Claims (60)

1. A computer-implemented method comprising:

receiving substructure data identifying substructure contours of an organ, and dose matrix data;

generating a first mesh of organ substructures for the organ based on the substructure data;

obtaining a dose threshold value;

generating a second mesh of an isodose volume based on filtering the dose matrix data based on the dose threshold value; and

displaying the first mesh of the organ substructures and the second mesh of the isodose volume within a same scene.

2. The computer-implemented method of claim 1 wherein generating the first mesh of organ substructures comprises:

generating a voxelized volume of the substructure contours; and

executing an image based meshing algorithm that operates on the voxelized volume of the substructure contours.

3. The computer-implemented method of claim 1 wherein generating the second mesh of the isodose volume comprises executing an image based meshing algorithm that operates on the filtered dose matrix data.

4. The computer-implemented method of claim 1 wherein the organ is a heart.

5. The computer-implemented method of claim 1 wherein generating the second mesh of the isodose volume comprises associating a plurality of dose value ranges with a unique identifier; and determining the unique identifier for each of a plurality of surface points of the second mesh based on the plurality of dose value ranges.

6. The computer-implemented method of claim 5 wherein determining the unique identifier for each of the plurality of surface points of the second mesh comprises:

determining each of a plurality of dosage values along a tangential line to each of the plurality of surface points;

determining a representative dosage value for each of the plurality of surface points based on the corresponding plurality of dosage values; and

determining the unique identifier for each of the plurality of surface points based on the corresponding representative dosage value.

7. The computer-implemented method of claim 6 comprising:

mapping the unique identifier for each of the plurality of surface points to a segmentation model;

generating an image of the segmentation model based on the mapped unique identifiers; and

displaying the image of the segmentation model.

8. The computer-implemented method of claim 7 wherein generating the image of the segmentation model comprises applying a color wash to the segmentation model based on the mapped unique identifiers.

9. The computer-implemented method of claim 5 wherein the unique identifier is a color.

10. A non-transitory computer readable medium storing instructions that, when executed by at least one processor, cause the at least one processor to perform operations comprising:

receiving substructure data identifying substructure contours for an organ, and dose matrix data;

generating a first mesh of organ substructures for the organ based on the substructure data;

obtaining a dose threshold value;

generating a second mesh of an isodose volume based on filtering the dose matrix data based on the dose threshold value; and

displaying the first mesh of the organ substructures and the second mesh of the isodose volume within a same scene.

11. The non-transitory computer readable medium of claim 10 wherein generating the first mesh of organ substructures comprises:

generating a voxelized volume of the substructure contours; and

executing an image based meshing algorithm that operates on the voxelized volume of the substructure contours.

12. The non-transitory computer readable medium of claim 10 wherein generating the second mesh of the isodose volume comprises associating a plurality of dose value ranges with a unique identifier; and determining the unique identifier for each of a plurality of surface points of the second mesh based on the plurality of dose value ranges.

13. The non-transitory computer readable medium of claim 12 wherein determining the unique identifier for each of the plurality of surface points of the second mesh comprises:

determining each of a plurality of dosage values along a tangential line to each of the plurality of surface points;

determining a representative dosage value for each of the plurality of surface points based on the corresponding plurality of dosage values; and

determining the unique identifier for each of the plurality of surface points based on the corresponding representative dosage value.

14. The non-transitory computer readable medium of claim 13 wherein the operations further comprise:

mapping the unique identifier for each of the plurality of surface points to a segmentation model;

generating an image of the segmentation model based on the mapped unique identifiers; and

displaying the image of the segmentation model.

15. A system comprising:

a computing device configured to:

receive-substructure data identifying substructure contours for an organ, and dose matrix data;

generate a first mesh of organ substructures for the organ based on the substructure data;

obtain a dose threshold value;

generate a second mesh of an isodose volume based on filtering the dose matrix data based on the dose threshold value; and

display the first mesh of the organ substructures and the second mesh of the isodose volume within a same scene.

16. The system of claim 15 , wherein to generate the first mesh of organ substructures, the computing device is configured to:

generate a voxelized volume of the substructure contours; and

execute an image based meshing algorithm that operates on the voxelized volume of the substructure contours.

17. The system of claim 15 , wherein to generate the second mesh of the isodose volume, the computing device is configured to associate a plurality of dose value ranges with a unique identifier; and determine the unique identifier for each of a plurality of surface points of the second mesh based on the plurality of dose value ranges.

18. The system of claim 17 , wherein to determine the unique identifier for each of the plurality of surface points of the second mesh, the computing device is configured to:

determine each of a plurality of dosage values along a tangential line to each of the plurality of surface points;

determine a representative dosage value for each of the plurality of surface points based on the corresponding plurality of dosage values; and

determine the unique identifier for each of the plurality of surface points based on the corresponding representative dosage value.

19. The system of claim 18 , wherein the computing device is configured to:

map the unique identifier for each of the plurality of surface points to a segmentation model;

generate an image of the segmentation model based on the mapped unique identifiers; and

display the image of the segmentation model.

20. The system of claim 15 , wherein to generate the second mesh of the isodose volume, the computing device is configured to execute an image based meshing algorithm that operates on the filtered dose matrix data.

Assignments (2)
CHANGE OF NAME Recorded Sep 11, 2024
From: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
To: SIEMENS HEALTHINEERS INTERNATIONAL AG
Reel/Frame 068946/0110 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 30, 2022
From: JOHNSON, LEIGH SCOTT; KUNZ, PATRIK NIKLAUS; MORGAN, ANDREA; ATTANASI, FRANCESCA; HONEGGER, JONAS MICHAEL; SCHEIB, STEFAN GEORG
To: VARIAN MEDICAL SYSTEMS, INC.; VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
Reel/Frame 062243/0697 →
Continuity (1)
Related Publication 20220351836A1 · Nov 3, 2022
References Cited (41)
US 11922634B2 · Peters · 2024 [cited by examiner]
US 20050143965A1 · Failla · 2005 [cited by examiner]
US 20080004543A1 · Davies · 2008 [cited by applicant]
US 20110166408A1 · Sumanaweera · 2011 [cited by examiner]
US 20130058460A1 · Weigand · 2013 [cited by examiner]
US 20130083004A1 · Nord · 2013 [cited by examiner]
US 20130113802A1 · Weersink et al. · 2013 [cited by applicant]
US 20130289332A1 · Purdie · 2013 [cited by examiner]
US 20140022250A1 · Mansi et al. · 2014 [cited by applicant]
US 20140171791A1 · Simon et al. · 2014 [cited by applicant]
US 20140282008A1 · Verard et al. · 2014 [cited by applicant]
US 20160332000A1 · Hale · 2016 [cited by examiner]
US 20160339268A1 · Bzdusek · 2016 [cited by examiner]
US 20180063386A1 · Sharma · 2018 [cited by examiner]
US 20190012066A1 · Ahonen · 2019 [cited by examiner]
US 20220288420A1 · Brown · 2022 [cited by examiner]
US 20230181929A1 · Sung · 2023 [cited by examiner]
CN 104318554A · 2015 [cited by applicant]
CN 107072595A · 2017 [cited by applicant]
WO 2010064154A1 · 2010 [cited by applicant]
WO 2011009121A1 · 2011 [cited by applicant]
WO 2017078757A1 · 2017 [cited by applicant]
WO 2019055491A1 · 2019 [cited by applicant]
WO 2019118640A1 · 2019 [cited by applicant]
Sung et al. Dose Gradient Curve: A New Tool for Evaluating Dose Gradient (Year: 2018). [cited by examiner]
Lobos et al. Techniques for the generation of 3D finite element meshes of human organs (Year: 2009). [cited by examiner]
Third Party Observations for European Patent Application No. 20746499.1 dated Feb. 29, 2024, 3 pages. [cited by applicant]
Blanck, et al., “Radiosurgery for ventricular tachycardia: preclinical and clinical evidence and study design for a German multi-center mult⋅⋅platform feasibility trial (RAVENTA),” Apr. 18, 2020. Clinical Research in Ca… [cited by applicant]
Brett, et al., “Novel Workflow for Conversion of Catheter-Based Electroanatomic Mapping to DICOM Imaging for Noninvasive Radioablation of Ventricular Tachycardia,” May 13, 2020. Pract Radiat Oncol., 11(1):84-88. [cited by applicant]
Wei, et al., “Non-invasive Stereotactic Radioablation: A New Option for the Treatment of Ventricular Arrhythmias,” Feb. 12, 2020. Arrhythm Electrophysiol Rev., 8(4):285-293. [cited by applicant]
Anonymous, “Remote Desktop Software-Wikipedia” Jun. 26, 2020 (Jun. 26, 2020), XP055727436, Retrieved from the Internet: URL:https://en.wikipedia.org/w/index.php?title= Remote_desktop_software&oldid=9645967 74 [retrieved… [cited by applicant]
Zellmer, et al., “The Shortage of radiation oncology physicists is addressable through remote treatment planning combined with periodic visits by consultant physicists”, Medical Physics, AIP, Melville, NY, US, vol. 35, … [cited by applicant]
International Search Report and Written Opinion for PCT International Application No. PCT/US2020/040808 dated Mar. 18, 2021, 14 pages. [cited by applicant]
International Search Report and Written Opinion for PCT International Application No. PCT/US2020/040812 dated Apr. 23, 2021, 14 pages. [cited by applicant]
Ferrante, et al., “Slice-to-volume medical image registration: A survey”, Medical Image Analysis, Apr. 2017, 39: 101-123. [cited by applicant]
Schwein, et al., “Feasibility of three-dimensional magnetic resonance angiography-fluoroscopy image fusion technique in guiding complex endovascular aortic procedures in patients with renal insufficiency”, Journal of Va… [cited by applicant]
Anonymous, “Medical Imaging Interaction Toolkit: The Rigid Registration View”, Dec. 2019, Retrieved from the Internet: URL:https://web.archive.org/web/2019121009 4930/https://docs.mitk.org/2016.11/org_mitk_views_rigidre… [cited by applicant]
Anonymous, “Optimized automatic registration 3D-MIPAV”, Oct. 2013, Retrieved from the Internet: URL:https://web.archive.org/web/2013102904 1146/https://mipav.cit.nih.gov/pubwiki/index.php/Optimized_automatic_registratio… [cited by applicant]
Sawaneh, et al., “A Computerized Patient's Database Management System” International Journal of Computer Science and Information Technology Research, Apr.-Jun. 2018, 6(2): 6-10. [cited by applicant]
Asabe, “Hospital Patient Database Management System” Compusoft, Mar. 2013, 2(3): 65-72. [cited by applicant]
International Search Report and Written Opinion for PCT International Application No. PCT/US2020/066213 dated Dec. 22, 2021, 21 pages. [cited by applicant]