Granted Patent
B2
US 12,708,433 · App. 17/644,998 · Granted Aug 18, 2026
Methods, systems and devices for endovascular electroporation of a greater splanchnic nerve
Inventors:
Mark Gelfand (New York, NY); Howard Levin (Teaneck, NJ); Daniel Alexander Smith (Boston, MA); Ali Shajii (Weston, MA)
Assignee:
AXON VASCULAR, INC.
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Abstract
Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.
Claims (33)
1 . A method of deactivating a greater splanchnic nerve (GSN) or a GSN root of a live patient, the method comprising:
delivering an ablation catheter to a target zone in a T9, T10 or T11 intercostal vein of the patient;
delivering electroporation energy from the ablation catheter, wherein a frequency of the electroporation energy is in a range of 300 kHz to 500 kHz;
deactivating the GSN or the GSN root; and
removing the ablation catheter from the patient.
2 . The method of claim 1 wherein the deactivating the GSN or the GSN root comprises delivering ablation energy from the ablation catheter.
3 . The method of claim 2 , wherein the ablation catheter comprises one or more energy delivery elements carried by an elongate shaft of the ablation catheter, wherein the electroporation energy and the ablation energy are delivered using the one or more energy delivery elements.
4 . The method of claim 3 , wherein the one or more energy delivery elements comprise one or more electrodes carried by the elongate shaft.
5 . The method of claim 1 , wherein the deactivating the GSN or the GSN root comprises ablating the GSN or the GSN root.
6 . The method of claim 5 , wherein the ablating the GSN or the GSN root comprises delivering RF ablation energy from the ablation catheter.
7 . The method of claim 5 , wherein the delivering electroporation energy from the ablation catheter causes the GSN or the GSN root to be ablated.
8 . The method of claim 1 , further comprising:
delivering a nerve stimulation signal from the ablation catheter before the delivering the electroporation energy, and
monitoring a first physiological reaction to the nerve stimulation signal.
9 . The method of claim 8 , further comprising:
delivering a second nerve stimulation signal from the ablation catheter after the delivering the electroporation energy, and
monitoring a second physiological reaction to the second nerve stimulation signal.
10 . The method of claim 9 , further comprising repeating the delivering electroporation energy in response to a determination that the second physiological reaction is not reduced compared to the first physiological reaction.
11 . The method of claim 1 , wherein the delivering the ablation catheter to the target zone in one of the T9, T10 or T11 intercostal veins comprises delivering the ablation catheter to a segment of the T9, T10 or T11 intercostal vein that is adjacent to an adjoining azygos vein.
12 . The method of claim 11 , wherein the segment is from 5 mm to 20 mm long.
13 . The method of claim 11 , wherein the segment is from 10 mm to 20 mm long.
14 . The method of claim 1 , wherein the delivering the ablation catheter to a target zone in one of the T9, T10 or T11 intercostal veins comprises delivering the ablation catheter that includes distal and proximal electrically conductive flexible and coiled ablation electrodes carried by a distal linear section of the ablation catheter.
15 . The method of claim 14 , wherein the distal and proximal electrically conductive flexible and coiled ablation electrodes together having an axial length in a rage of 5 mm to 25 mm, and an axial spacing therebetween that is not more than 2.0 mm.
16 . The method of claim 14 , wherein the distal and proximal electrically conductive flexible and coiled ablation electrodes each comprise a dielectric coating.
17 . The method of claim 1 , wherein the delivering electroporation energy temporarily deactivates one or more pain nerves in the target zone.
18 . The method of claim 1 , further comprising administering fentanyl or midazolam to the patient.
19 . The method of claim 1 , further comprising delivering saline from the ablation catheter to the patient.
20 . The method of claim 1 , wherein the delivering electroporation energy from the ablation catheter comprises delivering energy from an electroporation console with delivery parameters comprising:
a maximum power in a range of 30 W to 35 W,
a current that is one of DC or RF,
a pulse frequency in a range of 2 Hz to 4 Hz, and
a pulse on duration in a range of 0.5 ms to 2 ms.
21 . The method of claim 1 , wherein the delivering the electroporation energy comprises delivering electroporation energy in a duration in a range of 1 s to 120 s.
Assignments (9)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 3, 2025
From: EMPHYSYS, INC.
To: AXON THERAPIES, INC.
Reel/Frame 072466/0609 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 3, 2025
From: CORIDEA, LLC
To: AXON THERAPIES, INC.
Reel/Frame 072466/0844 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 3, 2025
From: GELFAND, MARK; LEVIN, HOWARD
To: CORIDEA LLC
Reel/Frame 072466/0671 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 3, 2025
From: SMITH, DANIEL ALEXANDER; SHAJII, ALI
To: EMPHYSYS, INC.
Reel/Frame 072466/0534 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 1, 2025
From: AXON THERAPIES, INC.
To: AXON (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC
Reel/Frame 071149/0588 →
PATENT ASSIGNMENT AGREEMENT
Recorded Nov 13, 2024
From: AXON (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC
To: AXON VASCULAR, INC.
Reel/Frame 069353/0549 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 28, 2022
From: EMPHYSYS, INC.
To: AXON THERAPIES, INC.
Reel/Frame 060341/0864 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 28, 2022
From: SMITH, DANIEL ALEXANDER; SHAJII, ALI
To: EMPHYSYS, INC.
Reel/Frame 060341/0779 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 28, 2022
From: GELFAND, MARK; LEVIN, HOWARD
To: AXON THERAPIES, INC.
Reel/Frame 060341/0630 →
Continuity (2)
Provisional Application
63130175
· Dec 23, 2020
Related Publication
20220323142A1
· Oct 13, 2022
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