Antiviral prodrugs and nanoformulations thereof
View Patent ↗The present invention provides prodrugs and methods of use thereof.
1. A method of inhibiting HIV integrase in a subject in need thereof, the method comprising administering to the subject an effective amount of a pharmaceutical composition comprising:
a) a compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein R is a saturated linear aliphatic chain of a length of 17 carbons, and
b) a pharmaceutically acceptable carrier.
2. The method of claim 1 , wherein the pharmaceutical composition is administered via injection.
3. The method of claim 1 , wherein the pharmaceutical composition is administered one time in a 3, 6, 9, 12, 18, or 24 month period.
4. The method of claim 1 , wherein the method inhibits integrase strand transfer.
5. The method of claim 1 , wherein the subject is human.
6. The method of claim 1 , wherein the subject is at risk of developing an HIV infection.
7. The method of claim 1 , wherein the subject is identified as having an HIV infection.