Halogenated esters of cyclopropanated unsaturated fatty acids for use in the treatment of neurodegenerative diseases
The present disclosure describes novel PKC-ε activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monounsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.
1. A method for treating a neuroaffective disorder, comprising administering to a patient having a neuroaffective disorder an effective amount of a cyclopropanated esterified version of 8-[2-(2-pentylcyclopropylmethyl)-cyclopropyl]-octanoic acid (DCPLA) containing an alkoxy group with at least one CF 3 group in the ester portion, wherein the neuroaffective disorder is selected from the group consisting of depression, bipolar disorder, schizophrenia, and post-traumatic stress disorder (PTSD).
2. The method of claim 1 , wherein the neuroaffective disorder is depression.
3. The method of claim 1 , wherein the cyclopropanated esterified fatty acid is selected from: