Granted Patent
B2
US 12,290,471 · App. 17/670,215 · Granted May 6, 2025
Fluid delivery alignment system
Inventors:
Daniel V. Palanker (Sunnyvale, CA); Yehuda Ivri (Newport Coast, CA); Mark S. Blumenkranz (Portola Valley, CA); Reynaldo Quintana (Menlo Park, CA)
Assignee:
BAUSCH + LOMB IRELAND LIMITED
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Abstract
Aspects of the invention include a device for fluid delivery to the ocular surface having a self-alignment system. The fluid delivery device includes a fluid package having a reservoir and one or more apertures, an actuator component configured to eject fluid from the reservoir through the one or more apertures and an image-based self-alignment system configured to align fluid ejected through the one or more apertures with a target location on the eye of a user. Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.
Claims (14)
1. A device for self-administration of a fluid to a target location, the device comprising:
a) a fluid delivery package having a reservoir including one or more apertures;
b) an actuator positioned adjacent the reservoir to act on the reservoir to eject fluid therefrom through the one or more apertures, the fluid being ejected towards the target location with a delivery time less than 150 ms; and
c) a concave mirror disposed downstream of the one or more apertures and having an opening through which the fluid ejected from the one or more apertures is directed, the concave mirror provided with a design to enable self-alignment of the device with the target location when an image of the target location is in focus and is centered in the concave mirror,
wherein the device further includes a housing, wherein the housing comprises a cover, and wherein the cover is configurable between an open position, in which the one or more apertures are exposed, and a closed position, in which the one or more apertures are not exposed, and wherein movement of the cover from the closed to the open position transitions the actuator from an inactive to active state.
2. The device according to claim 1 , where the concave mirror is spherical.
3. The device according to claim 2 , where the spherical mirror has a focal distance ranging from 10 to 100 mm.
4. The device according to claim 1 , wherein the device comprises a light source for illumination of the target location.
5. The device according to claim 1 , wherein the device further comprises a distance sensor configured to determine a distance between the device and the target location.
6. The device according to claim 5 , wherein the device is configured to provide a signal when the determined distance between the device and the target location is with a predetermined range.
7. The device according to claim 1 , wherein the one or more apertures are disposed at corresponding offsets relative to an optical axis of the concave mirror, and wherein the offsets are in a range from 1 mm to 20 mm.
8. The device according to claim 1 , wherein the device further includes a switch configured to control the actuator.
9. The device according to claim 1 , wherein the concave mirror is further configured to enable the self-alignment of the device by transitioning a blurry image, as viewed from an eye of a user, into an in-focus image in the concave mirror signifying to the user that the device is properly aligned.
10. The device according to claim 1 , wherein the concave mirror magnifies the image in the concave mirror to facilitate the self-alignment of the device.
Assignments (8)
ASSIGNMENT OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (066694/0131)
Recorded Aug 14, 2025
From: CITIBANK, N.A., AS RESIGNING AGENT
To: JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT
Reel/Frame 072460/0655 →
PATENT SECURITY AGREEMENT
Recorded Jul 1, 2025
From: BAUSCH & LOMB INCORPORATED; ALDEN OPTICAL LABORATORIES, INC.; BAUSCH + LOMB IRELAND LIMITED
To: CITIBANK, N.A., AS NOTES COLLATERAL AGENT
Reel/Frame 071773/0871 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT
Recorded Feb 29, 2024
From: BAUSCH + LOMB IRELAND LIMITED
To: CITIBANK, N.A., AS NOTES COLLATERAL AGENT
Reel/Frame 066707/0684 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT
Recorded Feb 27, 2024
From: BAUSCH + LOMB IRELAND LIMITED
To: CITIBANK, N.A., AS COLLATERAL AGENT
Reel/Frame 066694/0131 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 9, 2023
From: NOVARTIS AG
To: BAUSCH + LOMB IRELAND LIMITED
Reel/Frame 065531/0583 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNMENT AGREEMENT PREVIOUSLY RECORDED ON REEL 062116 FRAME 0917. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT.
Recorded Jul 10, 2023
From: KEDALION THERAPEUTICS, INC.
To: NOVARTIS AG
Reel/Frame 064237/0507 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 13, 2022
From: KEDALION THERAPEUTICS, INC.
To: NOVARTIS AG
Reel/Frame 062116/0917 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 24, 2022
From: PALANKER, DANIEL V.; IVRI, YEHUDA; BLUMENKRANZ, MARK S.; QUINTANA, REYNALDO
To: KEDALION THERAPEUTICS, INC.
Reel/Frame 059094/0668 →
Continuity (5)
Continuation
16463137
Provisional Application
62653446
· Apr 5, 2018
Provisional Application
62613908
· Jan 5, 2018
Provisional Application
62596668
· Dec 8, 2017
References Cited (353)
US 3640274A
· Costello
· 1972
[cited by applicant]
US 3779245A
· Windsor
· 1973
[cited by applicant]
US 3812854A
· Michaels et al.
· 1974
[cited by applicant]
US 3861386A
· Harris et al.
· 1975
[cited by applicant]
US 3934585A
· Maurice
· 1976
[cited by applicant]
US 3970250A
· Drews
· 1976
[cited by applicant]
US 3976072A
· Walker
· 1976
[cited by applicant]
US 4159803A
· Cameto et al.
· 1979
[cited by applicant]
US 4300546A
· Kruber
· 1981
[cited by applicant]
US 4334531A
· Reichl et al.
· 1982
[cited by applicant]
US 4338576A
· Takahashi et al.
· 1982
[cited by applicant]
US 4344744A
· Schuster et al.
· 1982
[cited by applicant]
US 4352459A
· Berger et al.
· 1982
[cited by applicant]
US 4465234A
· Maehara et al.
· 1984
[cited by applicant]
US 4632311A
· Nakane et al.
· 1986
[cited by applicant]
US 4655393A
· Berger
· 1987
[cited by applicant]
US 4793339A
· Matsumoto et al.
· 1988
[cited by applicant]
US 4850534A
· Takahashi et al.
· 1989
[cited by applicant]
US 4882150A
· Kaufman
· 1989
[cited by applicant]
US 4952581A
· Bito et al.
· 1990
[cited by applicant]
US 4961345A
· Tsuruoka et al.
· 1990
[cited by applicant]
US 4976259A
· Higson et al.
· 1990
[cited by applicant]
US 4981625A
· Rhim et al.
· 1991
[cited by applicant]
US 5025957A
· Ranalletta et al.
· 1991
[cited by applicant]
US 5171306A
· Vo
· 1992
[cited by applicant]
US 5232363A
· Meller
· 1993
[cited by applicant]
US 5368582A
· Bertera
· 1994
[cited by applicant]
US 5370317A
· Weston
· 1994
[cited by applicant]
US 5487378A
· Robertson et al.
· 1996
[cited by applicant]
US 5549249A
· Foster et al.
· 1996
[cited by applicant]
US 5624057A
· Lifshey
· 1997
[cited by applicant]
US 5627611A
· Scheiner
· 1997
[cited by applicant]
US 5630793A
· Rowe
· 1997
[cited by applicant]
US 5657926A
· Toda
· 1997
[cited by applicant]
US 5692651A
· Fuchs
· 1997
[cited by applicant]
US 5811443A
· DeSantis, Jr. et al.
· 1998
[cited by applicant]
US 5828394A
· Khuri-Yakub et al.
· 1998
[cited by applicant]
US 5938117A
· Ivri
· 1999
[cited by applicant]
US 5958342A
· Gamble et al.
· 1999
[cited by applicant]
US 5960224A
· Sanada et al.
· 1999
[cited by applicant]
US 6024717A
· Ball et al.
· 2000
[cited by applicant]
US 6062212A
· Davison et al.
· 2000
[cited by applicant]
US 6065623A
· Hierzer et al.
· 2000
[cited by applicant]
US 6095376A
· Hennemann et al.
· 2000
[cited by applicant]
US 6196218B1
· Voges
· 2001
[cited by applicant]
US 6232129B1
· Wiktor
· 2001
[cited by applicant]
US 6273092B1
· Nolan
· 2001
[cited by applicant]
US 6302101B1
· Py
· 2001
[cited by applicant]
US 6467476B1
· Ivri et al.
· 2002
[cited by applicant]
US RE38077E
· Cohen et al.
· 2003
[cited by applicant]
US 6543442B2
· Gonda et al.
· 2003
[cited by applicant]
US 6629646B1
· Ivri
· 2003
[cited by applicant]
US 6730066B1
· Bennwik et al.
· 2004
[cited by applicant]
US 6758837B2
· Péclat et al.
· 2004
[cited by applicant]
US 6869275B2
· Dante et al.
· 2005
[cited by applicant]
US 7066398B2
· Borland et al.
· 2006
[cited by applicant]
US 7105357B1
· Kalkum et al.
· 2006
[cited by applicant]
US 7201732B2
· Anderson et al.
· 2007
[cited by applicant]
US 7314938B2
· Shen et al.
· 2008
[cited by applicant]
US 7571722B2
· Wuttke et al.
· 2009
[cited by applicant]
US 7745460B2
· Shen et al.
· 2010
[cited by applicant]
US 7790743B2
· Shen et al.
· 2010
[cited by applicant]
US 7874467B2
· Pardes et al.
· 2011
[cited by applicant]
US 7883031B2
· Collins, Jr. et al.
· 2011
[cited by applicant]
US 7928122B2
· Shen et al.
· 2011
[cited by applicant]
US 8012136B2
· Collins, Jr. et al.
· 2011
[cited by applicant]
US 8048047B2
· Domash
· 2011
[cited by applicant]
US 8056766B2
· Grevin
· 2011
[cited by applicant]
US 8128606B2
· Anderson et al.
· 2012
[cited by applicant]
US 8133210B2
· Al-Abdulla et al.
· 2012
[cited by applicant]
US 8144399B2
· Steenblik et al.
· 2012
[cited by applicant]
US 8168655B2
· Gadek et al.
· 2012
[cited by applicant]
US 8273307B2
· Eickhoff et al.
· 2012
[cited by applicant]
US 8367701B2
· Burnier et al.
· 2013
[cited by applicant]
US 8398001B2
· Borland et al.
· 2013
[cited by applicant]
US 8435544B2
· Mitra et al.
· 2013
[cited by applicant]
US 8544462B2
· Papania et al.
· 2013
[cited by applicant]
US 8545463B2
· Collins, Jr. et al.
· 2013
[cited by applicant]
US 8592450B2
· Acheampong et al.
· 2013
[cited by applicant]
US 8629111B2
· Acheampong et al.
· 2014
[cited by applicant]
US 8633162B2
· Acheampong et al.
· 2014
[cited by applicant]
US 8642556B2
· Acheampong et al.
· 2014
[cited by applicant]
US 8648048B2
· Acheampong et al.
· 2014
[cited by applicant]
US 8684980B2
· Hunter et al.
· 2014
[cited by applicant]
US 8685930B2
· Acheampong et al.
· 2014
[cited by applicant]
US 8722728B2
· Wong et al.
· 2014
[cited by applicant]
US 8733935B2
· Ballou, Jr. et al.
· 2014
[cited by applicant]
US 8863998B2
· Painchaud et al.
· 2014
[cited by applicant]
US 8927574B2
· Burnier
· 2015
[cited by applicant]
US 8927921B1
· Nelms et al.
· 2015
[cited by applicant]
US 8936021B2
· Collins, Jr.
· 2015
[cited by applicant]
US 9039666B2
· Voss et al.
· 2015
[cited by applicant]
US 9068566B2
· Ivri
· 2015
[cited by applicant]
US 9085553B2
· Zeller et al.
· 2015
[cited by applicant]
US 9087145B2
· Ballou, Jr. et al.
· 2015
[cited by applicant]
US 9186690B2
· Scanlon et al.
· 2015
[cited by applicant]
US 9216174B2
· Shen et al.
· 2015
[cited by applicant]
US 9238532B2
· Decock et al.
· 2016
[cited by applicant]
US 9248191B2
· Acheampong et al.
· 2016
[cited by applicant]
US 9353088B2
· Burnier
· 2016
[cited by applicant]
US 9447077B2
· Burnier et al.
· 2016
[cited by applicant]
US 9597230B2
· Haffner et al.
· 2017
[cited by applicant]
US 9676525B2
· Greiner-Perth et al.
· 2017
[cited by applicant]
US 9700686B2
· Gavini et al.
· 2017
[cited by applicant]
US 9801757B2
· Voss et al.
· 2017
[cited by applicant]
US 9808825B2
· Aguilar et al.
· 2017
[cited by applicant]
US 9867933B2
· Pardes et al.
· 2018
[cited by applicant]
US 9890141B2
· Burnier
· 2018
[cited by applicant]
US 20010035184A1
· Schuler et al.
· 2001
[cited by applicant]
US 20010036424A1
· Takahashi et al.
· 2001
[cited by applicant]
US 20010036449A1
· Garst
· 2001
[cited by applicant]
US 20020078947A1
· Gumaste
· 2002
[cited by applicant]
US 20020124843A1
· Skiba et al.
· 2002
[cited by applicant]
US 20020158196A1
· Berggren et al.
· 2002
[cited by applicant]
US 20020161344A1
· Peclat et al.
· 2002
[cited by applicant]
US 20020185125A1
· Klimowicz et al.
· 2002
[cited by applicant]
US 20020190079A1
· Hamamoto
· 2002
[cited by applicant]
US 20030052573A1
· Wischnewskiy
· 2003
[cited by applicant]
US 20030065294A1
· Pickup et al.
· 2003
[cited by applicant]
US 20030071071A1
· Garcia et al.
· 2003
[cited by applicant]
US 20030140921A1
· Smith et al.
· 2003
[cited by applicant]
US 20040039355A1
· Gonzalez et al.
· 2004
[cited by applicant]
US 20040050861A1
· Lisec et al.
· 2004
[cited by applicant]
US 20040138630A1
· Al-Abdulla et al.
· 2004
[cited by applicant]
US 20040163645A1
· Connelly et al.
· 2004
[cited by applicant]
US 20040173642A1
· Clifford et al.
· 2004
[cited by applicant]
US 20040204674A1
· Anderson et al.
· 2004
[cited by applicant]
US 20040215157A1
· Peclat et al.
· 2004
[cited by applicant]
US 20040256487A1
· Collins, Jr. et al.
· 2004
[cited by applicant]
US 20040263567A1
· Hess et al.
· 2004
[cited by applicant]
US 20040267214A1
· Kerssies
· 2004
[cited by examiner]
US 20050001981A1
· Anderson et al.
· 2005
[cited by applicant]
US 20050006417A1
· Nicol et al.
· 2005
[cited by applicant]
US 20050107832A1
· Bernabei
· 2005
[cited by applicant]
US 20050172962A1
· Gumaste et al.
· 2005
[cited by applicant]
US 20050207917A1
· Koerner et al.
· 2005
[cited by applicant]
US 20050240162A1
· Chen et al.
· 2005
[cited by applicant]
US 20050261641A1
· Warchol et al.
· 2005
[cited by applicant]
US 20060065677A1
· Py et al.
· 2006
[cited by applicant]
US 20060069358A1
· Gerondale
· 2006
[cited by applicant]
US 20060147313A1
· Zengerle et al.
· 2006
[cited by applicant]
US 20060210604A1
· Dadey et al.
· 2006
[cited by applicant]
US 20070051362A1
· Sullivan et al.
· 2007
[cited by applicant]
US 20070088267A1
· Shekalim
· 2007
[cited by applicant]
US 20070088268A1
· Edwards
· 2007
[cited by applicant]
US 20070102455A1
· Stark et al.
· 2007
[cited by applicant]
US 20070119969A1
· Collins et al.
· 2007
[cited by applicant]
US 20070195151A1
· Anderson et al.
· 2007
[cited by applicant]
US 20070268340A1
· Dacquay et al.
· 2007
[cited by applicant]
US 20070295332A1
· Ziegler et al.
· 2007
[cited by applicant]
US 20080039807A1
· Pine
· 2008
[cited by applicant]
US 20080202514A1
· Kriksunov et al.
· 2008
[cited by applicant]
US 20080214940A1
· Benaron et al.
· 2008
[cited by applicant]
US 20080233053A1
· Gross et al.
· 2008
[cited by applicant]
US 20080247264A1
· Gabl et al.
· 2008
[cited by applicant]
US 20080257911A1
· Choi et al.
· 2008
[cited by applicant]
US 20090060793A1
· Eickhoff et al.
· 2009
[cited by applicant]
US 20090114742A1
· Collins, Jr.
· 2009
[cited by applicant]
US 20090134235A1
· Ivri
· 2009
[cited by applicant]
US 20090182291A1
· Eilat
· 2009
[cited by applicant]
US 20090192443A1
· Collins, Jr.
· 2009
[cited by applicant]
US 20090212127A1
· Reynolds et al.
· 2009
[cited by applicant]
US 20090212133A1
· Collins, Jr.
· 2009
[cited by applicant]
US 20090223513A1
· Papania et al.
· 2009
[cited by applicant]
US 20100001090A1
· Neergaard et al.
· 2010
[cited by applicant]
US 20100005903A1
· Beavis
· 2010
[cited by applicant]
US 20100013352A1
· Pletner et al.
· 2010
[cited by applicant]
US 20100044460A1
· Sauzade
· 2010
[cited by applicant]
US 20100072301A1
· Cater
· 2010
[cited by applicant]
US 20100072302A1
· Cater
· 2010
[cited by applicant]
US 20100076388A1
· Cater
· 2010
[cited by applicant]
US 20100147899A1
· Nardi
· 2010
[cited by applicant]
US 20100186738A1
· Kobayashi et al.
· 2010
[cited by applicant]
US 20100222752A1
· Collins, Jr. et al.
· 2010
[cited by applicant]
US 20100236545A1
· Kern
· 2010
[cited by applicant]
US 20100295420A1
· Wierach
· 2010
[cited by applicant]
US 20100326431A1
· Yu
· 2010
[cited by applicant]
US 20110074247A1
· Hohlfeld et al.
· 2011
[cited by applicant]
US 20110102735A1
· Gupta et al.
· 2011
[cited by applicant]
US 20110106025A1
· Hall et al.
· 2011
[cited by applicant]
US 20110146670A1
· Gallem et al.
· 2011
[cited by applicant]
US 20110284579A1
· Pardes et al.
· 2011
[cited by applicant]
US 20110293452A1
· Kim et al.
· 2011
[cited by applicant]
US 20110305425A1
· Fabrykowski et al.
· 2011
[cited by applicant]
US 20120017898A1
· Moller
· 2012
[cited by applicant]
US 20120062840A1
· Ballou, Jr. et al.
· 2012
[cited by applicant]
US 20120070467A1
· Ballou, Jr. et al.
· 2012
[cited by applicant]
US 20120143152A1
· Hunter et al.
· 2012
[cited by applicant]
US 20120179122A1
· Eilat et al.
· 2012
[cited by applicant]
US 20120197219A1
· Scanlon et al.
· 2012
[cited by applicant]
US 20120304929A1
· Ivri
· 2012
[cited by applicant]
US 20130002095A1
· Van der Linden
· 2013
[cited by applicant]
US 20130017283A1
· Zemel et al.
· 2013
[cited by applicant]
US 20130025038A1
· Frey et al.
· 2013
[cited by applicant]
US 20130053042A1
· Tanikawa et al.
· 2013
[cited by applicant]
US 20130079733A1
· Burt et al.
· 2013
[cited by applicant]
US 20130118619A1
· Loth et al.
· 2013
[cited by applicant]
US 20130140225A1
· Decock et al.
· 2013
[cited by applicant]
US 20130150812A1
· Hunter et al.
· 2013
[cited by applicant]
US 20130152796A1
· Pawl
· 2013
[cited by applicant]
US 20130153677A1
· Leen et al.
· 2013
[cited by applicant]
US 20130164436A1
· Yagi et al.
· 2013
[cited by applicant]
US 20130172830A1
· Hunter et al.
· 2013
[cited by applicant]
US 20130206857A1
· Ivri
· 2013
[cited by applicant]
US 20130299607A1
· Wilkerson et al.
· 2013
[cited by applicant]
US 20130345672A1
· Ferreri et al.
· 2013
[cited by applicant]
US 20140088524A1
· Marx
· 2014
[cited by applicant]
US 20140113946A1
· Abad
· 2014
[cited by applicant]
US 20140157956A1
· Date et al.
· 2014
[cited by applicant]
US 20140171490A1
· Gross et al.
· 2014
[cited by applicant]
US 20140187969A1
· Hunter
· 2014
[cited by examiner]
US 20140224267A1
· Levitz et al.
· 2014
[cited by applicant]
US 20140242022A1
· Vehige et al.
· 2014
[cited by applicant]
US 20140249491A1
· Ballou, Jr. et al.
· 2014
[cited by applicant]
US 20140257172A1
· Yalamanchili
· 2014
[cited by applicant]
US 20140274910A1
· Cumberlidge et al.
· 2014
[cited by applicant]
US 20140276054A1
· Hossack et al.
· 2014
[cited by applicant]
US 20140285121A1
· Balogh et al.
· 2014
[cited by applicant]
US 20140323931A1
· Avni
· 2014
[cited by applicant]
US 20140336596A1
· Wochele
· 2014
[cited by applicant]
US 20150018781A1
· Rinderknect et al.
· 2015
[cited by applicant]
US 20150035180A1
· Shen et al.
· 2015
[cited by applicant]
US 20150036219A1
· Shen et al.
· 2015
[cited by applicant]
US 20150086397A1
· Ma
· 2015
[cited by applicant]
US 20150097050A1
· Ciervo
· 2015
[cited by applicant]
US 20150139973A1
· Steinfeld et al.
· 2015
[cited by applicant]
US 20150144128A1
· Hijlkema et al.
· 2015
[cited by applicant]
US 20150209174A1
· Abreu
· 2015
[cited by applicant]
US 20150209178A1
· Blakey et al.
· 2015
[cited by applicant]
US 20150238689A1
· Shimizu
· 2015
[cited by applicant]
US 20150256730A1
· Shen et al.
· 2015
[cited by applicant]
US 20150276994A1
· Shen et al.
· 2015
[cited by applicant]
US 20150308421A1
· Vogt
· 2015
[cited by applicant]
US 20150328151A1
· Ballou, Jr. et al.
· 2015
[cited by applicant]
US 20150352297A1
· Stedman et al.
· 2015
[cited by applicant]
US 20160107180A1
· Decock et al.
· 2016
[cited by applicant]
US 20160120833A1
· Wan et al.
· 2016
[cited by applicant]
US 20160129467A1
· Ciardella et al.
· 2016
[cited by applicant]
US 20160199230A1
· Doshi et al.
· 2016
[cited by applicant]
US 20160213866A1
· Tan
· 2016
[cited by applicant]
US 20160263314A1
· Pardes et al.
· 2016
[cited by applicant]
US 20160354559A1
· Gavini et al.
· 2016
[cited by applicant]
US 20170028626A1
· Delrot et al.
· 2017
[cited by applicant]
US 20170138357A1
· Kondo et al.
· 2017
[cited by applicant]
US 20170151088A1
· Ballou, Jr. et al.
· 2017
[cited by applicant]
US 20170182510A1
· Wilkerson et al.
· 2017
[cited by applicant]
US 20170187969A1
· Kitamori et al.
· 2017
[cited by applicant]
US 20170344714A1
· Ballou, Jr. et al.
· 2017
[cited by applicant]
US 20180229247A1
· Laidler
· 2018
[cited by applicant]
US 20180236466A1
· Laidler
· 2018
[cited by applicant]
US 20190099071A1
· Ehrmann
· 2019
[cited by applicant]
US 20190314196A1
· Ivri et al.
· 2019
[cited by applicant]
US 20190314197A1
· Ivri et al.
· 2019
[cited by applicant]
US 20190314198A1
· Ivri et al.
· 2019
[cited by applicant]
US 20200197220A1
· Ivri
· 2020
[cited by applicant]
US 20200330267A1
· Li et al.
· 2020
[cited by applicant]
US 20220125631A1
· Ianchulev et al.
· 2022
[cited by applicant]
CN 103118642A
· 2013
[cited by applicant]
CN 104146816A
· 2014
[cited by applicant]
CN 104582647A
· 2015
[cited by applicant]
CN 204813955U
· 2015
[cited by applicant]
CN 105351426A
· 2016
[cited by applicant]
CN 107530509A
· 2018
[cited by applicant]
EP 0622035A1
· 1994
[cited by applicant]
EP 0622035B1
· 1999
[cited by applicant]
EP 1493410A2
· 2005
[cited by applicant]
JP H08251948A
· 1996
[cited by applicant]
JP 3055480U
· 1999
[cited by applicant]
JP 2007531577A
· 2007
[cited by applicant]
JP 2013535250A
· 2013
[cited by applicant]
KR 101258025B1
· 2013
[cited by applicant]
KR 1020130054352A
· 2013
[cited by applicant]
WO 1994020875A3
· 1995
[cited by applicant]
WO 1996000050A1
· 1996
[cited by applicant]
WO 2000005482A1
· 2000
[cited by applicant]
WO 2001046134A1
· 2001
[cited by applicant]
WO 2002072169A2
· 2002
[cited by applicant]
WO 2010078428A1
· 2010
[cited by applicant]
WO 2012009706A1
· 2012
[cited by applicant]
WO 2013076682A1
· 2013
[cited by applicant]
WO 2013090459A1
· 2013
[cited by applicant]
WO 2013090468A1
· 2013
[cited by applicant]
WO 2013155201A2
· 2013
[cited by applicant]
WO 2013158967A2
· 2013
[cited by applicant]
WO 2016115050A1
· 2016
[cited by applicant]
WO 2016164830A1
· 2016
[cited by applicant]
WO 2018136618A2
· 2018
[cited by applicant]
WO 2018227190A1
· 2018
[cited by applicant]
WO 2019113483A1
· 2019
[cited by applicant]
WO 2020010116A1
· 2020
[cited by applicant]
Abidi et al., “Lifilegrast: A Novel Drug for Treatment of Dry Eye Disease”, Journal of Pharmacology and Pharmacotherapy, 2016, vol. 7, pp. 194-198.
[cited by applicant]
Ali et al., “Glaucoma and Dry Eye”, Ophthalmology, 2009, vol. 116, p. 1232.
[cited by applicant]
Choi et al., “Generation of Controllable Monodispersed Sprays Using Impulse Jet and Charging Techniques”, Review of Scientific Instruments, 1990, vol. 61, pp. 1689-1693.
[cited by applicant]
Anchulev et al., “Pharmacodynamic Profile of Mydriatic Agents Delivered by Ocular Piezo-Ejection Microdosing Compared With Conventional Eyedropper”, 2016, Ther. Deliv., vol. 7, pp. 751-760.
[cited by applicant]
Jow et al., “Design and Optimization of Printed Spiral Coils for Efficient Transcutaneous Inductive Power Transmission”, IEEE Transactions on Biomedical Circuits and Systems, 2007, vol. 1, pp. 193-202.
[cited by applicant]
Kent, Christopher, “Getting Meds onto the Eye, 21st Century Style”, Mar. 15, 2013 [online]; [Retrieved on Aug. 27, 2019], Retrieved from the Internet <URL: https://www.reviewofophthalmology.com/article/getting-meds-onto…
[cited by applicant]
Lallemand et al., “Cyclosporine A Delivery to the Eye: A Comprehensive Review of Academic and Industrial Efforts”, European Journal of Pharmaceutics and Biopharmaceutics, 2017, vol. 117, pp. 14-28.
[cited by applicant]
Lindblad et al., “Production of Uniform-Sized Liquid Droplets”, Journal of Scientific Instruments, 1965, vol. 42, pp. 635-638.
[cited by applicant]
Lux et al., “A comparative bioavailability study of three conventional eye drops versus a single lyophilisate”, Br. J. Ophthalmol., 2003, vol. 87, pp. 436-440.
[cited by applicant]
Macmillan Online Dictionary, “Stream,” n.d. [online]; [Retrieved on Dec. 13, 2018]; Retrieved from the Internet <URL: https://macmillandictionary.com/dictionary/american/stream_ 1#stream_9>.
[cited by applicant]
Merriam-Webster, “Clamp,” 2019 [online]; [Retrieved on Oct. 25, 2022], Retrieved from the Internet <URL: https://www.merriam-webster.com/dictionary/clamp>.
[cited by applicant]
Murube et al., “Classification of Artificial Tears, I: Composition and Properties”, Advanced Experimental Medical Biology, 1998, vol. 438, pp. 693-704.
[cited by applicant]
Murube et al., Classification of Artificial Tears, II: Additives and Commercial Formulas, Advanced Experimental Medical Biology, 1998, vol. 438, pp. 705-715.
[cited by applicant]
Oxford Online Dictionary, “Stream,” n.d. [online]; [Retrieved on Dec. 13, 2018]; Retrieved from the Internet <URL: https://en.oxforddictionaries.com/definition/us/stream>.
[cited by applicant]
Vocabulary.com, “Stream,” n.d. [online]; [Retrieved on Dec. 13, 2018]; Retrieved from the Internet <URL: https://www.dictionary.com/stream>.
[cited by applicant]
International Search Report and Written Opinion dated Feb. 5, 2019 in corresponding International Patent Application No. PCT/US2018/064529 (9 pages).
[cited by applicant]
Birkhoff et al., “New Devices for Dispensing Ophthalmic Treatments May Be the Key to Managing the Life Cycles of Established Products”, 2010, Drug Delivery Technology, vol. 10, pp. 16-21.
[cited by applicant]
Brenton, “CRUK/10/30: TRICON8—Sample collection of ovarian cancer tissues and blood for translational research from patients participating in the CR-UK/MRC ICON8 trial”, 2015, online abstract.
[cited by applicant]
Denion et al., “A 5-Minute Interval between Two Dilating Eye Drops Increases Their Effect”, Jul. 19, 2017, Optometry and Vision Science, vol. 94, pp. 838-844.
[cited by applicant]
Electronic Tutorials, “Linear Solenoid Actuator”, 2016 [online]; [Retrieved on Oct. 17, 2022], Retrieved from the Internet [URL: https://www.electronics-tutorials.ws/io/io_6.html].
[cited by applicant]
Elert, Glenn, “Spherical mirrors”, The Physics Hypertextbook, 2021 [online]; [Retrieved on Oct. 17, 2022], Retrieved from the Internet [URL: https://physics.info/mirrors/].
[cited by applicant]
Gannon, Megan, “The Best Length for Eyelashes, According to Science”, Feb. 24, 2015 [online]; [Retrieved on Oct. 17, 2022], Retrieved from the Internet [URL: https://www.livescience.com/49934-optimal-length-for-eyelashe…
[cited by applicant]
Kompella et al., “ISOPT Clinical Hot Topic Panel Discussion on Ocular Drug Delivery”, 2019, J. Ocul. Pharmacol. Ther., vol. 35, pp. 457-465.
[cited by applicant]
Marx et al., “Opthalmic Squeeze Dispenser: Eliminating the Need for Additives in Multidose Preservative-Free Eyecare Formulations”, 2017, Drug Development Delivery, vol. 17, pp. 40-44.
[cited by applicant]
Merriam-Webster, “Collimate,” 2020 [online]; [Retrieved on Oct. 17, 2022], Retrieved from the Internet [URL: https:// www.merriam-webster.com/dictionary/collimated].
[cited by applicant]
Merriam-Webster, “Stream,” n.d. [online]; [Retrieved on Dec. 13, 2018], Retrieved from the Internet [URL: https://www.merriam-webster.com/dictionary/stream].
[cited by applicant]
Pronin et al., “Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor”, 2017, Mol. Pharmacol., vol. 92, pp. 601-612.
[cited by applicant]