Granted Patent
B2
US 12,616,832 · App. 17/670,351 · Granted May 5, 2026
Systems and methods for delivering neuroregenerative therapy
Assignee:
Epineuron Technologies Inc.
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Abstract
Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.
Claims (34)
1 . A method of stimulating a target nerve in a subject, comprising:
positioning at least one electrode assembly of a stimulation device adjacent the target nerve, wherein the at least one electrode is located along an electrode lead of the stimulation device;
wherein the at least one electrode assembly is positioned adjacent the target nerve percutaneously;
delivering stimulation energy to the target nerve of the subject having a first frequency via the at least one electrode to confirm at least one validation condition;
delivering stimulation energy to the target nerve of the subject having a second frequency via the at least one electrode assembly, wherein delivering stimulation energy to the subject to create a regenerative effect to the target nerve;
wherein stimulation energy to confirm at least one validation condition and to create a regenerative effect to the target nerve is provided by the same at least one electrode; and
wherein the at least one electrode assembly is configured to be percutaneously removed from the subject through a percutaneous access point following the delivery of stimulation energy; and
removing the at least one electrode assembly from the subject.
2 . The method of claim 1 ,
wherein the second frequency is 1 Hz to 100 Hz;
wherein the target nerve comprises a peripheral nerve; and
wherein the stimulation device is configured to be removably secured to a skin surface of the subject using an adhesive patch.
3 . The method of claim 1 , wherein the second frequency is 1 Hz to 100 Hz.
4 . The method of claim 1 , wherein the second frequency is 10 Hz to 100 Hz.
5 . The method of claim 1 , wherein the at least one electrode assembly comprises a bipolar electrode assembly.
6 . The method of claim 1 , wherein delivering stimulation energy occurs intraoperatively.
7 . The method of claim 1 , wherein delivering stimulation energy occurs postoperatively.
8 . The method of claim 1 , wherein delivering stimulation energy to create a regenerative effect occurs for a particular time period.
9 . The method of claim 8 , wherein the particular time period is 10 to 90 minutes.
10 . The method of claim 1 , wherein positioning the at least one electrode assembly adjacent the target nerve is performed with assistance of an insertion tool.
11 . The method of claim 1 , wherein the stimulation device is configured to be removably secured to a skin surface of the subject using an adhesive patch.
12 . The method of claim 1 , further comprising modifying at least one operational parameter of the stimulation energy using at least one controller of the stimulation device.
13 . The method of claim 1 , wherein the target nerve comprises a peripheral nerve.
14 . A method of stimulating a target nerve in a subject, comprising:
positioning at least one electrode assembly adjacent the target nerve;
wherein the at least one electrode assembly is positioned adjacent the target nerve percutaneously; and
delivering stimulation energy to the target nerve of the subject to confirm at least one validation condition;
delivering stimulation energy to the target nerve of the subject via the at least one electrode assembly, wherein delivering stimulation energy to the subject creates a regenerative effect to the target nerve;
wherein the at least one electrode assembly is configured to be percutaneously removed from the subject through a percutaneous access point following the delivery of stimulation energy; and
removing the at least one electrode assembly from the subject.
15 . The method of claim 14 , wherein delivering stimulation energy occurs intraoperatively.
16 . The method of claim 14 , wherein delivering stimulation energy occurs postoperatively.
17 . The method of claim 14 , wherein the at least one electrode assembly comprises a bipolar electrode assembly.
18 . The method of claim 14 , wherein the stimulation device is configured to be removably secured to a skin surface of the subject using an adhesive patch.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 22, 2022
From: WILLAND, MICHAEL PATRICK; AGUIRRE, SERGIO DAVID
To: EPINEURON TECHNOLOGIES INC.
Reel/Frame 059344/0728 →
Continuity (4)
Continuation
16759257
Provisional Application
62683019
· Jun 11, 2018
Provisional Application
62577141
· Oct 25, 2017
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