IP Library Granted Patent US 11,989,619
Granted Patent B2
US 11,989,619 · App. 17/681,155 · Granted May 21, 2024

Modifying messages stored in mixtures of molecules using thin-layer chromatography

Inventors: George M. Whitesides (Newton, MA); Albert Siangyoong Wong (Enschede, NL); Michael Johannes Fink (Cambridge, MA); Khaled Abdelazim Mohamed (Cambridge, MA); Alexei S. Ten (Evanston, IL); Milan M. Mrksich (Hinsdale, IL)
Assignees: President and Fellows of Harvard College; Northwestern University
G06K7/1434B01J19/0046G01N30/90G06K19/06037B01J2219/00605B01J2219/00659B01J2219/00695B01J2219/00725
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 11,989,619
App. No.
17/681,155
Granted
May 21, 2024
Kind
B2
Abstract

Storage media are provided. A substrate has an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of molecules, each collection comprising at least a first subcollection of molecules and a second subcollection of molecules. The molecules in the collection are selected from a set of unambiguously identifiable molecules, the set comprising at least a first subset of molecules and a second subset of molecules. Each molecule in the first subset is identifiable by a first physical property, and each molecule in the second subset is identifiable by a second physical property, different from the first physical property. Each molecule in the set is uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position.

Claims (16)

1. A method of writing data to a machine-readable medium, the method comprising:

receiving a numerical value comprising a set of digit/position pairs, the set comprising at least a first subset of digit/position pairs, and a second subset of digit/position pairs;

receiving an association between at least the first and the second subsets of digit/position pairs and the set of digit/position pairs;

receiving a one-to-one association between at least the first subset of digit/position pairs and a first subset of molecules, and the second subset of digit/position pairs and a second subset of molecules, the first and the second subsets of molecules each selected from a set of unambiguously identifiable molecules, wherein each molecule in the first subset is identifiable by a first physical property, and each molecule in the second subset is identifiable by a second physical property, different from the first physical property;

determining a collection of molecules corresponding to the numerical value, wherein determining the collection comprises:

determining at least a first subcollection of molecules corresponding to the first subset of digit/position pairs, and a second subcollection of molecules corresponding the second subset of digit/position pairs, and

including at least the first and the second subcollections into the collection of molecules; and

physically associating the molecules of the collection with a substrate of the machine-readable medium at an addressable location thereon.

2. A method of reading data from a machine-readable medium, the method comprising:

receiving an association between a set of digit/position pairs and at least a first and a second subsets of digit/position pairs;

receiving a one-to-one association between at least the first subset of digit/position pairs and a first subset of molecules, and the second subset of digit/position pairs and a second subset of molecules, the first and the second subset of molecules selected from a set of unambiguously identifiable molecules, wherein each molecule in the first subset is identifiable by a first physical property, and each molecule in the second subset is identifiable by a second physical property, different from the first physical property;

receiving a collection of molecules physically associated with a substrate of the machine-readable medium at an addressable location thereon, the collection comprising at least a first subcollection of molecules selected from the first subset of molecules, and a second subcollection of molecules, selected from the second subset of molecules;

determining a numerical value comprising the set of digit/position pairs from the collection of molecules, wherein determining the numerical value comprises:

setting each position of the first subset of digit/position pairs to the digit whose associated molecule is present in the first subcollection;

setting each position of the second subset of digit/position pairs to the digit whose associated molecule is present in the second subcollection; and

combining the first and the second subsets of digit/position pairs.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 22, 2023
From: ABDELAZIM, KHALED MOHAMED; WHITESIDES, GEORGE M.; WONG, SIANGYOONG ALBERT; FINK, MICHAEL JOHANNES
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 063714/0858 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 22, 2023
From: MRKSICH, MILAN; TEN, ALEXEI
To: NORTHWESTERN UNIVERSITY
Reel/Frame 063715/0062 →
Continuity (3)
Continuation PCTUS2020048190 · Aug 27, 2020
Provisional Application 62892171 · Aug 27, 2019
Related Publication 20220180083A1 · Jun 9, 2022