IP Library › Granted Patent US 12,370,309
Granted Patent B2
US 12,370,309 · App. 17/687,808 · Granted Jul 29, 2025

Adaptive update of automatic insulin delivery (AID) control parameters

Inventors: Joon Bok Lee (Acton, MA); Yibin Zheng (Hartland, WI); Jason O'Connor (Acton, MA)
Assignee: INSULET CORPORATION
A61M5/1723A61B5/14532A61B5/4839A61M5/142G06Q30/0283G16H20/17A61M2005/14208A61M2205/52A61M2230/201
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Quick Facts
Patent No.
US 12,370,309
App. No.
17/687,808
Granted
Jul 29, 2025
Kind
B2
Abstract

Exemplary embodiments may modify the cost function parameters based on current and projected mean outcomes in blood glucose level control performance. The exemplary embodiments may modify the weight coefficient R for the insulin cost so that the value of R is not fixed and is not based solely on clinical determined values. Exemplary embodiments may also adjust the cost function to address persistent low-level blood glucose level excursions for users. The exemplary embodiments may reduce the penalty of the insulin cost by the sum of the converted insulin cost of the glucose excursions above target for a period divided by a number of cycles of average insulin action time. The AID system reduces the insulin cost by the lack of insulin in previous cycles.

Claims (34)

1. A device for controlling insulin deliveries to a user by an insulin pump, comprising:

a glucose sensor interface with a glucose sensor to obtain glucose readings for the user from the glucose sensor;

an insulin pump interface for communicating with the insulin pump to control delivery of insulin to the user by the insulin pump;

a processor configured to implement a control loop to control the delivery of insulin by the insulin pump, wherein the processor selects an insulin delivery dosage for a next delivery among delivery dosage options that has a best value of a cost function and wherein the cost function for each of the delivery dosage options:

has a glucose cost component reflective of a difference between a glucose level that the delivery dosage option is predicted to produce for the user and a glucose level for the user relative to a projected glucose level with basal insulin delivery,

has an insulin cost component reflective of a difference between a deviation of the delivery dosage option from a current basal insulin dosage and a converted amount of insulin needed to compensate for glucose excursions above a target for an interval of time, wherein the processor is configured to calculate the converted amount of insulin needed to compensate for glucose excursions above the target for the interval of time by determining a magnitude of the glucose excursions above the target for the interval,

has a glucose cost weight coefficient for weighting the glucose cost component, and

has an insulin cost weight coefficient for weighting the insulin cost component.

2. The device for controlling insulin deliveries of claim 1 , wherein the device for controlling insulin deliveries is a drug delivery device that includes the insulin pump.

3. The device for controlling insulin deliveries of claim 1 , wherein the device for controlling insulin deliveries is a management device for the insulin pump that does not include the insulin pump.

4. The device for controlling insulin deliveries of claim 1 , wherein the processor is configured to determine the magnitude of the glucose excursions above the target for the interval of time by summing glucose excursions above a target of blood glucose level for each cycle in the interval.

5. The device for controlling insulin deliveries of claim 4 , wherein the processor is configured for determining the converted amount of insulin needed to compensate for glucose excursions above the target for the interval of time by applying a conversion factor to the determined magnitude of the glucose excursions above the target.

6. A device for controlling insulin deliveries to a user from by an insulin pump, comprising:

a glucose sensor interface with a glucose sensor to obtain glucose readings for the user from the glucose sensor;

an insulin pump interface for communicating with the insulin pump to control delivery of insulin to the user by the insulin pump; and

one or more processors configured to implement a control loop to control the delivery of insulin by the insulin pump such that the processor selects an insulin delivery dosage for a next delivery among delivery dosage options that has a best value of a cost function and also configured to implement a parallel integral control approach that requests an additional insulin dosage from the insulin pump to eliminate positive glucose excursions that are not eliminated by the control loop and that does not request insulin when there are not positive glucose excursions to be eliminated.

7. The device for controlling insulin deliveries of claim 6 , wherein the device for controlling insulin deliveries is one of an insulin delivery device or a management device for the for controlling insulin delivery device.

8. The device for controlling insulin deliveries of claim 7 , wherein the one or more processors are configured so that the parallel integral approach determines an amount of insulin needed to eliminate a current magnitude of a positive glucose excursion.

9. The device for controlling insulin deliveries of claim 8 , wherein the one or more processors are configured so that the parallel integral approach determines an aggregate magnitude of glucose excursions for a past number of cycles.

10. The device for controlling insulin deliveries of claim 9 , wherein the one or more processors are configured so that the parallel integral approach determines a product of the aggregate magnitude of glucose excursions for a past number of cycles and a tuning factor.

11. The device for controlling insulin deliveries of claim 10 , wherein the one or more processors are configured so that the parallel integral approach selects either the amount of insulin needed to eliminate a current magnitude of a positive glucose excursion or the product as the additional insulin dosage.

12. A device for controlling insulin deliveries to a user by an insulin pump, comprising:

a glucose sensor interface with a glucose sensor to obtain glucose readings for the user from the glucose sensor;

an insulin pump interface for communicating with the insulin pump to control delivery of insulin to the user by the insulin pump;

a processor configured to implement a control loop to control the delivery of insulin by the insulin pump, wherein the processor selects an insulin delivery dosage for a next delivery among the delivery dosage options that has a best value of a cost function and wherein the cost function for each of the delivery dosage options:

has a glucose cost component reflective of a difference between a glucose level that the delivery dosage option is predicted to produce for the user and a target glucose level for the user,

has an insulin cost component reflective of a deviation of the delivery dosage option from a current basal insulin dosage,

has a glucose cost weight coefficient for weighting the glucose cost component, and

has an insulin cost weight coefficient for weighting the insulin cost component, wherein the insulin cost weight coefficient is based on a ratio of time in a desired range for glucose values of the user and maximum time in the desired range from a history of glucose values for the user and wherein the insulin cost weight coefficient increases in value as the ratio of time in a desired range for glucose values of the user and maximum time in the desired range from a history of glucose values for the user increases.

13. The device for controlling insulin deliveries of claim 12 , wherein the insulin cost weight coefficient is also based on a base value for the insulin cost weight coefficient.

14. The device for controlling insulin deliveries of claim 12 , wherein the maximum time in the desired range is a percentage value.

15. The device for controlling insulin deliveries of claim 12 , wherein the processor is configured to determine the maximum time in the desired range based on an average target blood glucose value of the user over the history of glucose values for the user.

16. The device for controlling insulin deliveries of claim 15 , wherein the processor is configured to determine the maximum time in the desired range based additionally on a percentage of time that glucose values for the user were in range over the history of glucose values for the user.

17. The device for controlling insulin deliveries of claim 12 , wherein the device for controlling insulin deliveries is one of an insulin delivery device or a management device for an insulin delivery device.

Assignments (2)
SECURITY AGREEMENT SUPPLEMENT Recorded Dec 1, 2022
From: INSULET CORPORATION
To: MORGAN STANLEY SENIOR FUNDING, INC., AS COLLATERAL AGENT
Reel/Frame 062035/0785 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 5, 2022
From: LEE, JOON BOK; ZHENG, YIBIN; O'CONNOR, JASON
To: INSULET CORPORATION
Reel/Frame 059498/0160 →
Continuity (3)
Provisional Application 63165252 · Mar 24, 2021
Provisional Application 63158918 · Mar 10, 2021
Related Publication 20220288311A1 · Sep 15, 2022
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