BEZIMIDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS
The invention relates to benzimidazole derivatives of the general formula I, and the use of the compounds of the present invention for the treatment and/or prevention of hyperproliferative or infectious diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.
1 . (canceled)
2 . The method according to claim 14 , wherein
R 1 is Hal or linear or branched alkyl having 1-10 C atoms which is unsubstituted or mono-, di- or trisubstituted by R 4 and in which 1-4 C atoms may be replaced, independently of one another, by O, S, SO, SO 2 , NH, NCH 3 , —OCO—, —NHCONH—, —NHCO—, —NR 5 SO 2 R 6 —, —COO—, —CONH—, —NCH 3 CO—, —CONCH 3 —, —C≡C— groups and/or —CH═CH— groups, and/or, in addition, 1-10 H atoms may be replaced by F and/or Cl, or one of the following structures:
which is unsubstituted or mono-, di- or trisubstituted with R 4
and wherein Q, Y, R 2 , R 3 , R 4 , R 5 and R 6 have the meanings as disclosed in claim 1 , and physiologically acceptable salts, solvates, prodrugs and stereoisomers thereof, including mixtures thereof in all ratios.
3 . The method according to claim 14 , wherein R 1 is Br or one of the following structures:
which is unsubstituted or mono-, di- or trisubstituted with R 5
and wherein Q, Y, R 2 , R 3 , R 4 , R 5 and R 6 have the meanings as disclosed in claim 1 , and physiologically acceptable salts, solvates, prodrugs and stereoisomers thereof, including mixtures thereof in all ratios.
4 . The method according to claim 14 , wherein R 2 is one of the following structures:
which is unsubstituted or mono-, di- or trisubstituted with R 5
and wherein Q, Y, R 1 , R 3 , R 4 , R 5 and R 6 have the meanings as disclosed in claim 1 , and physiologically acceptable salts, solvates, prodrugs and stereoisomers thereof, including mixtures thereof in all ratios.
5 . The method according to claim 1 , wherein
R 3 one of the following structures
and Q, Y, R 1 , R 2 , R 4 , R 5 and R 6 have the meanings as disclosed in claim 1 , and physiologically acceptable salts, solvates, prodrugs and stereoisomers thereof, including mixtures thereof in all ratios.
6 . The method according to claim 14 , wherein
R 3 is OMe
and Q, Y, R 1 , R 2 , R 4 , R 5 and R 6 have the meanings as disclosed in claim 14 , and physiologically acceptable salts, solvates, prodrugs and stereoisomers thereof, including mixtures thereof in all ratios.
7 . The method according to claim 14 , wherein the compound of formula I is selected from the group consisting of:
No.
IUPAC-Name
1
7-Methoxy-4-phenyl-1H-benzoimidazol-2-ylamine
2
4-Fluoro-N-(7-methoxy-4-phenyl-1H-benzoimidazol-2-yl)-
benzamide
3
2-Bromo-N-(7-methoxy-4-phenyl-1H-benzoimidazol-2-yl)-
isonicotinamide
4
2-Bromo-N-(4-bromo-7-methoxy-1H-benzoimidazol-2-yl)-
isonicotinamide
5
6-Bromo-N-(7-methoxy-4-phenyl-1H-benzoimidazol-2-yl)-
nicotinamide
6
6-Bromo-N-(4-bromo-7-methoxy-1H-benzoimidazol-2-yl)-
nicotinamide
7
N-(7-Methoxy-4-phenyl-1H-benzoimidazol-2-yl)-2-morpholin-4-yl-
isonicotinamide
8
N-(7-Methoxy-4-phenyl-1H-benzoimidazol-2-yl)-6-morpholin-4-yl-
nicotinamide
9
N′-(7-Methoxy-4-phenyl-1H-benzoimidazol-2-yl)-N,N-dimethyl-
formamidine
10
4-Chloromethyl-N-(7-methoxy-4-phenyl-1H-benzoimidazol-2-yl)-
benzamide
11
4-Ethylaminomethyl-N-(7-methoxy-4-phenyl-1H-benzoimidazol-2-
yl)-benzamide
12
4-Hydroxy-4-methyl-piperidine-1-carboxylic acid (7-methoxy-4-
phenyl-1H-benzoimidazol-2-yl)-amide
13
4-Aminomethyl-N-(7-methoxy-4-phenyl-1H-benzoimidazol-2-yl)-
benzamide
14
4-Cyclohexyl-7-methoxy-1H-benzoimidazol-2-ylamine
15
4-Imidazol-1-ylmethyl-N-(7-methoxy-4-phenyl-1H-benzoimidazol-
2-yl)-benzamide
16
4-Hydroxy-4-methyl-piperidine-1-carboxylic acid (4-cyclohexyl-7-
methoxy-1H-benzoimidazol-2-yl)-amide
17
N-(4-Cyclohexyl-7-methoxy-1H-benzoimidazol-2-yl)-2-morpholin-
4-yl-isonicotinamide
18
7-Methoxy-4-morpholin-4-yl-1H-benzoimidazol-2-ylamine
19
7-Methoxy-4-(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-ylamine
20
7-Methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-
ylamine
21
4-hydroxy-N-(7-methoxy-4-morpholino-1H-benzimidazol-2-yl)-4-
methyl-piperidine-1-carboxamide
22
4-Hydroxy-4-methyl-piperidine-1-carboxylic acid [7-methoxy-4-(1-
methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
23
N-(7-Methoxy-4-morpholin-4-yl-1H-benzoimidazol-2-yl)-2-
morpholin-4-yl-isonicotinamide
24
4-Hydroxy-4-methyl-piperidine-1-carboxylic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
25
4-Methoxy-7-phenyl-3H-imidazo[4,5-c]pyridin-2-ylamine
26
N-[7-Methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-
yl]-2-morpholin-4-yl-isonicotinamide
27
4-Methoxy-7-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridin-
2-ylamine
28
4-Methyl-piperidine-1-carboxylic acid (7-methoxy-4-phenyl-1H-
benzoimidazol-2-yl)-amide
29
N-[7-Methoxy-4-(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-
6-morpholin-4-yl-nicotinamide
30
2-(3-Hydroxy-3-methyl-pyrrolidin-1-yl)-N-[7-methoxy-4-(1-methyl-
1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-isonicotinamide
31
3-Hydroxy-3-methyl-pyrrolidine-1-carboxylic acid [7-methoxy-4-
(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
32
4-Hydroxy-4-trifluoromethyl-piperidine-1-carboxylic acid [7-
methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-
amide
33
2-Oxa-7-aza-spiro[3.5]nonane-7-carboxylic acid [7-methoxy-4-(1-
methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
34
4-Difluoromethyl-4-hydroxy-piperidine-1-carboxylic acid [7-
methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-
amide
35
4-Hydroxymethyl-4-methyl-piperidine-1-carboxylic acid [7-
methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-
amide
36
4-Fluoromethyl-4-hydroxy-piperidine-1-carboxylic acid [7-
methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-
amide
37
4-Methoxy-piperidine-1-carboxylic acid [7-methoxy-4-(1-methyl-
1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
38
3-Oxa-9-aza-spiro[5.5]undecane-9-carboxylic acid [7-methoxy-4-
(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
39
4-Methyl-piperidine-1-carboxylic acid [7-methoxy-4-(1-methyl-1H-
pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
40
4-Hydroxy-piperidine-1-carboxylic acid [7-methoxy-4-(1-methyl-
1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
41
4-Benzyl-4-hydroxy-piperidine-1-carboxylic acid [7-methoxy-4-(1-
methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
42
N-[4-methoxy-7-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-
c]pyridin-2-yl]-2-(morpholin-4-yl)pyridine-4-carboxamide
43
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-2-oxa-6-azaspiro[3.4]octane-6-carboxamide
44
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxamide
45
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxamide
46
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]morpholine-4-carboxamide
47
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-3-oxo-2,8-diazaspiro[4.5]decane-8-carboxamide
48
4-[(dimethylamino)methyl]-N-[7-methoxy-4-(1-methyl-1H-
pyrazol-4-yl)-1H-1,3-benzodiazol-2-yl]benzamide
49
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-4-(methoxymethyl)benzamide
50
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxamide
51
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxamide
52
4-(2-hydroxyethyl)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-
1H-1,3-benzodiazol-2-yl]-1,2,3,6-tetrahydropyridine-1-
carboxamide
53
3-butyl-4-hydroxy-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-
1,3-benzodiazol-2-yl]piperidine-1-carboxamide
54
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-4-phenoxypiperidine-1-carboxamide
55
4-hydroxy-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-4-(pyridin-3-yl)piperidine-1-carboxamide
56
4-hydroxy-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-3-(2-methylpropyl)piperidine-1-carboxamide
57
N-[4-(2,6-dimethylpyridin-4-yl)-7-methoxy-1H-1,3-benzodiazol-2-
yl]-2-(morpholin-4-yl)pyridine-4-carboxamide
58
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-4-oxopiperidine-1-carboxamide
59
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]acetamide
60
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxamide
61
3,3-diethyl-1-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]urea
62
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1-methyl-5-oxo-1,4,9-triazaspiro[5.5]undecane-9-carboxamide
63
4-fluoro-N-[7-methoxy-4-(morpholin-4-yl)-1H-1,3-benzodiazol-2-
yl]benzamide
64
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-6-oxaspiro[2.5]octane-1-carboxamide
65
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-5-{3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy}pyrazine-2-
carboxamide
66
(chloromethyl)({2-[(1-{[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-
1H-1,3-benzodiazol-2-yl]carbamoyl}-4-methylpiperidin-4-
yl)oxy]ethyl})dimethylazanium hydrochloride
67
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-7-oxa-2-azaspiro[4.5]decane-2-carboxamide
68
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-8-oxa-2-azaspiro[4.5]decane-2-carboxamide
69
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-2-oxa-7-azaspiro[4.4]nonane-7-carboxamide
70
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide
71
4-[(1H-imidazol-1-yl)methyl]-N-[7-methoxy-4-(1-methyl-1H-
pyrazol-4-yl)-1H-1,3-benzodiazol-2-yl]benzamide
72
(lS,2S)-2-bromo-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-
1,3-benzodiazol-2-yl]cyclopropane-1-carboxamide
73
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-5-(2-methoxyethoxy)pyrazine-2-carboxamide
74
4-hydroxy-N-[7-methoxy-4-(pyridin-4-yl)-1H-1,3-benzodiazol-2-yl]-
4-methylpiperidine-1-carboxamide
75
4-benzyl-4-hydroxy-N-[7-methoxy-4-(morpholin-4-yl)-1H-1,3-
benzodiazol-2-yl]piperidine-1-carboxamide
76
4-[(1H-imidazol-1-yl)methyl]-N-[7-methoxy-4-(morpholin-4-yl)-1H-
1,3-benzodiazol-2-yl]benzamide
77
N-[7-methoxy-4-(morpholin-4-yl)-1H-1,3-benzodiazol-2-yl]-1-
benzofu ran-5-carboxamide
78
4-hydroxy-N-{7-methoxy-4-[1-(oxan-2-yl)-1H-pyrazol-4-yl]-1H-1,3-
benzodiazol-2-yl}-4-methylpiperidine-1-carboxamide
79
4-hydroxy-N-[7-methoxy-4-(1H-pyrazol-4-yl)-1H-1,3-benzodiazol-
2-yl]-4-methylpiperidine-1-carboxamide
80
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1-benzofuran-5-carboxamide
81
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-5-(morpholin-4-yl)pyrazine-2-carboxamide
82
4-hydroxy-N-[4-methoxy-7-(1-methyl-1H-pyrazol-4-yl)-3H-
imidazo[4,5-c]pyridin-2-yl]-4-methylpiperidine-1-carboxamide
83
4-benzyl-4-hydroxy-N-[4-methoxy-7-(1-methyl-1H-pyrazol-4-yl)-
3H-imidazo[4,5-c]pyridin-2-yl]piperidine-1-carboxamide
84
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1,2-oxazole-3-carboxamide
85
N-[7-methoxy-4-(pyridin-4-yl)-1H-1,3-benzodiazol-2-yl]-2-oxa-6-
azaspiro[3.4]octane-6-carboxamide
86
1-(1-chloro-3-hydroxypropan-2-yl)-N-[7-methoxy-4-(morpholin-4-
yl)-1H-1,3-benzodiazol-2-yl]-1H-pyrazole-4-carboxamide
87
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-6-(morpholin-4-yl)pyridazine-3-carboxamide
88
4-[(dimethylamino)methyl]-N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-
benzodiazol-2-yl]benzamide
89
4-[(dimethylamino)methyl]-N-[7-methoxy-4-(pyridin-4-yl)-1H-1,3-
benzodiazol-2-yl]benzamide
90
4-[(dimethylamino)methyl]-N-[7-methoxy-4-(morpholin-4-yl)-1H-
1,3-benzodiazol-2-yl]benzamide
91
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-6-
(morpholin-4-yl)pyridazine-3-carboxamide
92
4-hydroxy-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-4-(prop-2-yn-1-yl)piperidine-1-carboxamide
93
N4-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-
2-yl]-N1,N1-dimethylbenzene-1,4-dicarboxamide
94
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-4-(trifluoromethoxy)benzamide
95
2-bromo-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]pyridine-4-carboxamide
96
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-2-methyl-1,3-oxazole-4-carboxamide
97
4-[(1H-imidazol-1-yl)methyl]-N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-
benzodiazol-2-yl]benzamide
98
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1,3-benzoxazole-5-carboxamide
99
3-amino-4-hydroxy-N-[7-methoxy-4-(morpholin-4-yl)-1H-1,3-
benzodiazol-2-yl]benzamide
100
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-4-[(2-oxopyrrolidin-1-yl)methyl]benzamide
101
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-2,3-dihydro-1-benzofuran-5-carboxamide
102
4-hydroxy-N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-4-
(prop-2-yn-1-yl)piperidine-1-carboxamide
103
4-benzyl-4-hydroxy-N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-
benzodiazol-2-yl]piperidine-1-carboxamide
104
2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-N-[7-methoxy-4-(1-
methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-yl]pyridine-4-
carboxamide
105
2-(4-hydroxy-4-methylpiperidin-1-yl)-N-[7-methoxy-4-(1-methyl-
1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-yl]pyridine-4-carboxamide
106
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-2-{2-oxa-7-azaspiro[4.4]nonan-7-yl}pyridine-4-carboxamide
107
2-[(3R)-3-hydroxy-3-methylpyrrolidin-1-yl]-N-[7-methoxy-4-(1-
methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-yl]pyridine-4-
carboxamide
108
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-2,3-dihydro-
l-benzofuran-5-carboxamide
109
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-3-(methoxymethyl)pyrrolidine-1-carboxamide
110
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-2-oxa-7-
azaspiro[4.4]nonane-7-carboxamide
111
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-8-oxa-2-
azaspiro[4.5]decane-2-carboxamide
112
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-hexahydro-
1H-furo[3,4-c]pyrrole-5-carboxamide
113
(5R)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-7-oxa-2-azaspiro[4.5]decane-2-carboxamide
114
(5S)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-7-oxa-2-azaspiro[4.5]decane-2-carboxamide
115
(5S)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-2-oxa-7-azaspiro[4.4]nonane-7-carboxamide
116
(5R)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-2-oxa-7-azaspiro[4.4]nonane-7-carboxamide
117
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-3-
(methoxymethyl)pyrrolidine-1-carboxamide
118
2-(4-hydroxy-4-methylpiperidin-1-yl)-N-[7-methoxy-4-(oxan-4-yl)-
1H-1,3-benzodiazol-2-yl]pyridine-4-carboxamide
119
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-2-{2-oxa-7-
azaspiro[4.4]nonan-7-yl}pyridine-4-carboxamide
120
2-(4-fluorophenoxy)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-
1H-1,3-benzodiazol-2-yl]-2-methylpropanamide
121
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-hexahydro-1H-furo[3,4-c]pyrrole-5-carboxamide
122
2-(3-hydroxy-3-methylpyrrolidin-1-yl)-N-[7-methoxy-4-(oxan-4-yl)-
1H-1,3-benzodiazol-2-yl]pyridine-4-carboxamide
123
N-[7-methoxy-4-(morpholin-4-yl)-1H-1,3-benzodiazol-2-yl]-2-oxa-
7-azaspiro[4.4]nonane-7-carboxamide
124
l-{[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]carbamoyl}piperidine-4-carboxylic acid
125
N-[7-methoxy-4-(morpholin-4-yl)-1H-1,3-benzodiazol-2-yl]-8-oxa-
2-azaspiro[4.5]decane-2-carboxamide
126
N1-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-
2-yl]piperidine-1,4-dicarboxamide
127
4-(diethylamino)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-
1,3-benzodiazol-2-yl]benzamide
128
4-hydroxy-N-{7-methoxy-4-[1-(2-methylpropyl)-1H-pyrazol-4-yl]-
1H-1,3-benzodiazol-2-yl}-4-methylpiperidine-1-carboxamide
129
N-[7-methoxy-4-(pyridin-4-yl)-1H-1,3-benzodiazol-2-yl]-8-oxa-2-
azaspiro[4.5]decane-2-carboxamide
130
2-(1-{[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-
yl]carbamoyl}piperidin-4-yl)acetic acid
131
4-hydroxy-N-[7-methoxy-4-(2-methylphenyl)-1H-1,3-benzodiazol-
2-yl]-4-methylpiperidine-1-carboxamide
132
2-(1-{[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]carbamoyl}piperidin-4-yl)acetic acid
133
N4-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-N1,N1-
dimethylbenzene-1,4-dicarboxamide
134
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-3-(2-methoxyethyl)pyrrolidine-1-carboxamide
135
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-5-(morpholin-4-yl)pyridine-2-carboxamide
136
N-[7-methoxy-4-(morpholin-4-yl)-1H-1,3-benzodiazol-2-yl]-1-
methyl-1H-pyrazole-4-carboxamide
137
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-3-(2-
methoxyethyl)pyrrolidine-1-carboxamide
138
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-4-[(2-
oxopyrrolidin-1-yl)methyl]benzamide
139
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-5-
(morpholin-4-yl)pyridine-2-carboxamide
140
(3R)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-3-(2-methoxyethyl)pyrrolidine-1-carboxamide
141
(3S)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-3-(2-methoxyethyl)pyrrolidine-1-carboxamide
142
2-[(3R)-3-hydroxy-3-methylpyrrolidin-1-yl]-N-[7-methoxy-4-(oxan-
4-yl)-1H-1,3-benzodiazol-2-yl]acetamide
143
2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-N-[7-methoxy-4-(oxan-
4-yl)-1H-1,3-benzodiazol-2-yl]acetamide
144
N-[4-(4-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-4-
hydroxy-4-methylpiperidine-1-carboxamide
145
tert-butyl 4-(4-{2-[(4-hydroxy-4-methylpiperidine-1-
carbonyl)amino]-4-methoxy-1H-1,3-benzodiazol-7-yl}-1H-pyrazol-
l-yl)piperidine-1-carboxylate
146
4-{[2-amino-7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-1-yl]methyl}benzoic acid
147
(3S)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-3-(methoxymethyl)pyrrolidine-1-carboxamide
148
(3R)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-3-(methoxymethyl)pyrrolidine-1-carboxamide
149
(5S)-N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-2-oxa-7-
azaspiro[4.4]nonane-7-carboxamide
150
(5R)-N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-2-oxa-
7-azaspiro[4.4]nonane-7-carboxamide
151
4-hydroxy-N-{7-metho x y-4-[1-(3-methylbutyl)-1H-pyrazol-4-yl]-
1H-1,3-benzodiazol-2-yl}-4-methylpiperidine-1-carboxamide
152
N-[7-metho x y-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-4-[(morpholin-4-yl)methyl]benzamide
153
N-[7-metho x y-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-2-[(5R)-2-
oxa-7-azaspiro[4.4]nonan-7-yl]pyridine-4-carboxamide
154
N-[7-metho x y-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-2-[(5S)-2-
oxa-7-azaspiro[4.4]nonan-7-yl]pyridine-4-carboxamide
155
N-[4-(3,6-dihydro-2H-pyran-4-yl)-7-methoxy-1H-1,3-benzodiazol-
2-yl]-4-hydroxy-4-methylpiperidine-1-carboxamide
156
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1-methyl-1H-1,2,3-triazole-4-carboxamide
157
4-hydroxy-N-{4-methoxy-7-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1H-
1,3-benzodiazol-2-yl}-4-methylpiperidine-1-carboxamide
158
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-5-(2-methoxyethoxy)pyridine-2-carboxamide
159
2-(1-{[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]carbamoyl}piperidin-3-yl)acetic acid
160
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1-methyl-1H-pyrazole-4-carboxamide
161
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1-(2-methoxyethyl)-1H-pyrazole-4-carboxamide
162
N5-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-
2-yl]-N2,N2-dimethylpyridine-2,5-dicarboxamide
163
4-hydroxy-N-[4-methoxy-1-methyl-7-(1-methyl-1H-pyrazol-4-yl)-
1H-1,3-benzodiazol-2-yl]-4-methylpiperidine-1-carboxamide
164
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1-(2-methoxyethyl)-1H-1,2,3-triazole-4-carboxamide
165
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-2-methyl-1,3-thiazole-5-carboxamide
166
3-cyano-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]propanamide
167
1-(2-Hydroxy-ethyl)-1H-pyrazole-4-carboxylic acid [7-methoxy-4-
(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
168
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide
169
1-Methyl-1H-pyrazole-4-carboxylic acid [7-methoxy-4-(1-methyl-
1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
170
5-Methyl-isoxazole-4-carboxylic acid [7-methoxy-4-(1-methyl-1H-
pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
171
5-Cyclopropyl-isoxazole-4-carboxylic acid [7-methoxy-4-(1-methyl-
1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
172
1-Cyano-cyclopropanecarboxylic acid [7-methoxy-4-(1-methyl-1H-
pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
173
Thiazole-5-carboxylic acid [7-methoxy-4-(1-methyl-1H-pyrazol-4-
yl)-1H-benzoimidazol-2-yl]-amide
174
5,6,7,8-Tetrahydro-imidazo[1,2-a]pyridine-3-carboxylic acid [7-
methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-
amide
175
4-(4-Methyl-piperazin-1-yl)-but-2-ynoic acid [7-methoxy-4-(1-
methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
176
4-Hydroxy-but-2-ynoic acid [7-methoxy-4-(1-methyl-1H-pyrazol-4-
yl)-1H-benzoimidazol-2-yl]-amide
177
4-Acetylamino-but-2-ynoic acid [7-methoxy-4-(1-methyl-1H-
pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
178
4-Dimethylamino-but-2-ynoic acid [7-methoxy-4-(1-methyl-1H-
pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
179
(S)-3-Methanesulfonyl-pyrrolidine-1-carboxylic acid [7-methoxy-4-
(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
180
(S)-3-Fluoro-pyrrolidine-1-carboxylic acid [7-methoxy-4-(1-methyl-
1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
181
(S)-3-Cyano-pyrrolidine-1-carboxylic acid [7-methoxy-4-(1-methyl-
1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-amide
182
(R)-3-Dimethylaminomethyl-pyrrolidine-1-carboxylic acid [7-
methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-benzoimidazol-2-yl]-
amide
183
5-Methyl-isoxazole-4-carboxylic acid (7-methoxy-4-morpholin-4-
yl-1H-benzoimidazol-2-yl)-amide
184
N-[7-methoxy-4-(morpholin-4-yl)-1H-1,3-benzodiazol-2-yl]-1-(2-
methoxyethyl)-1H-1,2,3-triazole-4-carboxamide
185
1-Methyl-1H-[1,2,3]triazole-4-carboxylic acid (7-methoxy-4-
morpholin-4-yl-1H-benzoimidazol-2-yl)-amide
186
Pyridine-2,5-dicarboxylic acid 2-dimethylamide 5-{[7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide}
187
1-(2-Methoxy-ethyl)-1H-pyrazole-4-carboxylic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
188
N-[7-Methoxy-4-(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-
4-morpholin-4-ylmethyl-benzamide
189
N-[7-Methoxy-4-(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-
4-(4-methyl-piperazin-1-ylmethyl)-benzamide
190
1-Methyl-1H-pyrazole-4-carboxylic acid [7-methoxy-4-(tetrahydro-
pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
191
5-Methyl-isoxazole-4-carboxylic acid [7-methoxy-4-(tetrahydro-
pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
192
5-Cyclopropyl-isoxazole-4-carboxylic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
193
1-(2-Methoxy-ethyl)-1H-[1,2,3]triazole-4-carboxylic acid [7-
methoxy-4-(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
194
1-Methyl-1H-[1,2,3]triazole-4-carboxylic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
195
1-Cyano-cyclopropanecarboxylic acid [7-methoxy-4-(tetrahydro-
pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
196
Thiazole-5-carboxylic acid [7-methoxy-4-(tetrahydro-pyran-4-yl)-
1H-benzoimidazol-2-yl]-amide
197
2-Methyl-oxazole-5-carboxylic acid [7-methoxy-4-(tetrahydro-
pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
198
2-Methyl-thiazole-5-carboxylic acid [7-methoxy-4-(tetrahydro-
pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
199
Imidazo[1,2-a]pyridine-3-carboxylic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
200
5-Amino-2H-[1,2,4]triazole-3-carboxylic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
201
(S)-3-Methanesulfonyl-pyrrolidine-1-carboxylic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
202
(S)-3-Fluoro-pyrrolidine-1-carboxylic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
203
(S)-3-Cyano-pyrrolidine-1-carboxylic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
204
(R)-3-Dimethylaminomethyl-pyrrolidine-1-carboxylic acid [7-
methoxy-4-(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
205
Pyrazolo[1,5-a]pyridine-3-carboxylic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
206
1H-[1,2,4]Triazole-3-carboxylic acid [7-methoxy-4-(tetrahydro-
pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
207
5,6,7,8-Tetrahydro-imidazo[1,2-a]pyridine-3-carboxylic acid [7-
methoxy-4-(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
208
2,3-Dimethyl-3H-imidazole-4-sulfonic acid [7-methoxy-4-
(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-amide
209
l-[7-Methoxy-4-(tetrahydro-pyran-4-yl)-1H-benzoimidazol-2-yl]-3-
thiazol-2-ylmethyl-urea
210
N-[7-methoxy-4-(morpholin-4-yl)-1H-1,3-benzodiazol-2-yl]-1-
methyl-1H-1,2,3-triazole-4-carboxamide
211
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-1-(2-
methoxyethyl)-1H-1,2,3-triazole-4-carboxamide
212
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-1-methyl-
1H-1,2,3-triazole-4-carboxamide
213
l-cyano-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]cyclopropane-1-carboxamide
214
N5-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-N2,N2-
dimethylpyridine-2,5-dicarboxamide
215
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-2-methyl-1,3-oxazole-5-carboxamide
216
N-[4-(azepan-1-yl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-4-
hydroxy-4-methylpiperidine-1-carboxamide
217
N-[4-(3-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-4-
hydroxy-4-methylpiperidine-1-carboxamide
218
N-[4-(2-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-4-
hydroxy-4-methylpiperidine-1-carboxamide
219
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1,3-thiazole-5-carboxamide
220
(3R)-3-methanesulfonyl-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-
yl)-1H-1,3-benzodiazol-2-yl]pyrrolidine-1-carboxamide
221
(3S)-3-fluoro-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]pyrrolidine-1-carboxamide
222
4-hydroxy-N-[7-methoxy-4-(1-methyl-6-oxo-1,6-dihydropyridin-3-
yl)-1H-1,3-benzodiazol-2-yl]-4-methylpiperidine-1-carboxamide
223
(3S)-3-(aminomethyl)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-
1H-1,3-benzodiazol-2-yl]pyrrolidine-1-carboxamide
224
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-1-methyl-
1H-pyrazole-4-carboxamide
225
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-1-(2-
methoxyethyl)-1H-pyrazole-4-carboxamide
226
l-cyano-N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-
yl]cyclopropane-1-carboxamide
227
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-2-methyl-
1,3-thiazole-5-carboxamide
228
3-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-1-[(1,3-
thiazol-2-yl)methyl]urea
229
N-{7-[1-(difluoromethyl)-1H-pyrazol-4-yl]-4-methoxy-1H-1,3-
benzodiazol-2-yl}-4-hydroxy-4-methylpiperidine-1-carboxamide
230
4-hydroxy-N-(4-methoxy-7-{l-[2-(2-methoxyethoxy)ethyl]-1H-
pyrazol-4-yl}-1H-1,3-benzodiazol-2-yl)-4-methylpiperidine-1-
carboxamide
231
4-hydroxy-N-{4-methoxy-7-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]-1H-
1,3-benzodiazol-2-yl}-4-methylpiperidine-1-carboxamide
232
N-[7-methoxy-4-(1-propylcyclopropyl)-1H-1,3-benzodiazol-2-yl]-1-
methyl-1H-pyrazole-4-carboxamide
233
N-[4-(hexan-3-yl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-1-methyl-
1H-pyrazole-4-carboxamide
234
N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-2-methyl-
1,3-oxazole-5-carboxamide
235
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide
236
4-hydroxy-N-{4-methoxy-7-[3-(2-methoxyethoxy)phenyl]-1H-1,3-
benzodiazol-2-yl}-4-methylpiperidine-1-carboxamide
237
4-hydroxy-N-(4-methoxy-7-{l-[(pyridin-3-yl)methyl]-1H-pyrazol-4-
yl}-1H-1,3-benzodiazol-2-yl)-4-methylpiperidine-1-carboxamide
238
4-hydroxy-N-{7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-4-
methoxy-1H-1,3-benzodiazol-2-yl}-4-methylpiperidine-1-
carboxamide
239
N-[4-(3-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-1-
methyl-1H-pyrazole-4-carboxamide
240
N4-[4-(3-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-
N1,N1-dimethylbenzene-1,4-dicarboxamide
241
4-hydroxy-N-{4-methoxy-7-[1-(oxolan-3-yl)-1H-pyrazol-4-yl]-1H-
1,3-benzodiazol-2-yl}-4-methylpiperidine-1-carboxamide
242
N4-[4-(2-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-
N1,N1-dimethylbenzene-1,4-dicarboxamide
243
N-[4-(2-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-1-
methyl-1H-pyrazole-4-carboxamide
244
N-[4-methoxy-1-methyl-7-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-
benzodiazol-2-yl]-1-methyl-1H-pyrazole-4-carboxamide
245
tert-butyl 3-(4-{2-[(4-hydroxy-4-methylpiperidine-1-
carbonyl)amino]-4-methoxy-1H-1,3-benzodiazol-7-yl}-1H-pyrazol-
1-yl)azetidine-1-carboxylate
246
N-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-5-oxopyrrolidine-3-carboxamide
247
3-[7-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]-1-[(1,3-thiazol-2-yl)methyl]urea
248
4-(2,5-dioxopyrrolidin-1-yl)-N-[7-methoxy-4-(1-methyl-1H-pyrazol-
4-yl)-1H-1,3-benzodiazol-2-yl]benzamide
249
l-[(3R,4S)-4-fluoropyrrolidin-3-yl]-3-[7-methoxy-4-(1-methyl-1H-
pyrazol-4-yl)-1H-1,3-benzodiazol-2-yl]urea
250
4-(2,5-dioxopyrrolidin-1-yl)-N-[7-methoxy-4-(oxan-4-yl)-1H-1,3-
benzodiazol-2-yl]benzamide
251
tert-butyl (3S,4R)-3-fluoro-4-({[7-methoxy-4-(1-methyl-1H-
pyrazol-4-yl)-1H-1,3-benzodiazol-2-
yl]carbamoyl}amino)pyrrolidine-1-carboxylate
252
N4-[7-methoxy-4-(1,2,3,6-tetrahydropyridin-4-yl)-1H-1,3-
benzodiazol-2-yl]-N1,N1-dimethylbenzene-1,4-dicarboxamide
253
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-1H-imidazole-4-
carboxamide
254
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-1-methyl-1H-
imidazole-5-carboxamide
255
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-2-methyl-1H-
imidazole-4-carboxamide
256
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-1,3-thiazole-5-
carboxamide
257
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-2-methyl-1,3-
thiazole-5-carboxamide
258
2-amino-N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-1,3-
thiazole-5-carboxamide
259
N4-[7-methoxy-4-(pyridin-3-yl)-1H-1,3-benzodiazol-2-yl]-N1,N1-
dimethylbenzene-1,4-dicarboxamide
260
N-[7-methoxy-4-(pyridin-3-yl)-1H-1,3-benzodiazol-2-yl]-1-methyl-
1H-pyrazole-4-carboxamide
261
N4-[4-(2,5-dihydrofuran-3-yl)-7-methoxy-1H-1,3-benzodiazol-2-
yl]-N1,N1-dimethylbenzene-1,4-dicarboxamide
262
N4-[4-(3,6-dihydro-2H-pyran-4-yl)-5-fluoro-7-methoxy-1H-1,3-
benzodiazol-2-yl]-N1,N1-dimethylbenzene-1,4-dicarboxamide
263
3-{[dimethyl(oxo)-lambda6-sulfanylidene]amino}-N-[7-methoxy-4-
(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]benzamide
264
N-[4-(3,6-dihydro-2H-pyran-4-yl)-5-fluoro-7-methoxy-1H-1,3-
benzodiazol-2-yl]-1-methyl-1H-pyrazole-4-carboxamide
265
N-[7-(3-fluorophenyl)-4-methoxy-1H-1,3-benzodiazol-2-yl]-1H-
imidazole-4-carboxamide
266
N-[4-methoxy-7-(pyridin-4-yl)-1H-1,3-benzodiazol-2-yl]-1H-
imidazole-4-carboxamide
267
N-{4-methoxy-7-[3-(2-methoxyethoxy)phenyl]-1H-1,3-
benzodiazol-2-yl}-1H-imidazole-4-carboxamide
268
N-[4-methoxy-7-(pyridin-3-yl)-1H-1,3-benzodiazol-2-yl]-1H-
imidazole-4-carboxamide
269
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-1,3-dimethyl-1H-
pyrazole-4-carboxamide
270
4-hydroxy-N-(7-methoxy-4-{1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-1,3-
benzodiazol-2-yl)-4-methylpiperidine-1-carboxamide
271
4-hydroxy-N-[4-(1H-indazol-4-yl)-7-methoxy-1H-1,3-benzodiazol-
2-yl]-4-methylpiperidine-1-carboxamide
272
4-hydroxy-N-[4-(1H-indol-6-yl)-7-methoxy-1H-1,3-benzodiazol-2-
yl]-4-methylpiperidine-1-carboxamide
273
4-hydroxy-N-[7-methoxy-4-(1-methyl-1H-indazol-5-yl)-1H-1,3-
benzodiazol-2-yl]-4-methylpiperidine-1-carboxamide
274
4-hydroxy-N-[7-methoxy-4-(3-methyl-1H-indazol-5-yl)-1H-1,3-
benzodiazol-2-yl]-4-methylpiperidine-1-carboxamide
275
4-hydroxy-N-(4-{imidazo[1,2-a]pyridin-7-yl}-7-methoxy-1H-1,3-
benzodiazol-2-yl)-4-methylpiperidine-1-carboxamide
276
(2Z)-2-cyano-3-hydroxy-N-(7-methoxy-4-phenyl-1H-1,3-
benzodiazol-2-yl)but-2-enamide
277
N4-[5-fluoro-7-methoxy-4-(oxan-4-yl)-1H-1,3-benzodiazol-2-yl]-
N1,N1-dimethylbenzene-1,4-dicarboxamide
278
N-(7-methoxy-4-{1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-1,3-
benzodiazol-2-yl)-1-(2-methoxyethyl)-1H-pyrazole-4-carboxamide
279
N-[4-(1H-indazol-4-yl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-1-(2-
methoxyethyl)-1H-pyrazole-4-carboxamide
280
N-[4-(1H-indol-6-yl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-1-(2-
methoxyethyl)-1H-pyrazole-4-carboxamide
281
N-[7-methoxy-4-(1-methyl-1H-indazol-5-yl)-1H-1,3-benzodiazol-2-
yl]-1-(2-methoxyethyl)-1H-pyrazole-4-carboxamide
282
N-[7-methoxy-4-(3-methyl-1H-indazol-5-yl)-1H-1,3-benzodiazol-2-
yl]-1-(2-methoxyethyl)-1H-pyrazole-4-carboxamide
283
N-[4-(2,3-dihydro-1H-indol-4-yl)-7-methoxy-1H-1,3-benzodiazol-2-
yl]-1-(2-methoxyethyl)-1H-pyrazole-4-carboxamide
284
N2-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-N5,N5-
dimethylpyridine-2,5-dicarboxamide
285
4-(2,5-dioxopyrrolidin-1-yl)-N-(7-methoxy-4-phenyl-1H-1,3-
benzodiazol-2-yl)benzamide
286
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)imidazo[1,2-
a]pyridine-3-carboxamide
287
4,4-difluoro-N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-
yl)piperidine-1-carboxamide
288
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)imidazo[1,2-
b]pyridazine-3-carboxamide
289
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)imidazo[1,2-
a]pyrimidine-3-carboxamide
290
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-2-(pyridin-4-yl)-
1H-imidazole-4-carboxamide
291
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-5H,6H,7H,8H-
imidazo[1,2-a]pyridine-3-carboxamide
292
N-[4-(2,3-dihydro-1H-indol-4-yl)-7-methoxy-1H-1,3-benzodiazol-2-
yl]-4-hydroxy-4-methylpiperidine-1-carboxamide
293
N1-(4-methoxy-7-phenyl-1H-1,3-benzodiazol-2-yl)-N4-
propylbenzene-1,4-dicarboxamide
294
N-(4-methoxy-7-phenyl-1H-1,3-benzodiazol-2-yl)-4-(4-
methylpiperazine-1-carbonyl)benzamide
295
N4-(4-methoxy-7-phenyl-1H-1,3-benzodiazol-2-yl)-N1-(2-
methoxyethyl)-N1-methylbenzene-1,4-dicarboxamide
296
N1-[2-(dimethylamino)ethyl]-N4-(4-methoxy-7-phenyl-1H-1,3-
benzodiazol-2-yl)-N1-methylbenzene-1,4-dicarboxamide
297
N4-(4-methoxy-7-phenyl-1H-1,3-benzodiazol-2-yl)-N1-methyl-N1-
propylbenzene-1,4-dicarboxamide
298
N-(4-methoxy-7-phenyl-1H-1,3-benzodiazol-2-yl)-4-(morpholine-
4-carbonyl)benzamide
299
N-[4-methoxy-7-(2-methylpyridin-4-yl)-1H-1,3-benzodiazol-2-yl]-
1H-imidazole-4-carboxamide
300
N-(5-cyano-7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-1-
methyl-1H-pyrazole-4-carboxamide
301
N-(4-{imidazo[1,2-a]pyridin-7-yl}-7-methoxy-1H-1,3-benzodiazol-
2-yl)-1-(2-methoxyethyl)-1H-pyrazole-4-carboxamide
302
N-[4-(1H-indol-5-yl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-1-(2-
methoxyethyl)-1H-pyrazole-4-carboxamide
303
4-hydroxy-N-[4-(1H-indol-5-yl)-7-methoxy-1H-1,3-benzodiazol-2-
yl]-4-methylpiperidine-1-carboxamide
304
N-[4-(1H-indol-7-yl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-1-(2-
methoxyethyl)-1H-pyrazole-4-carboxamide
305
4-hydroxy-N-[4-(1H-indol-7-yl)-7-methoxy-1H-1,3-benzodiazol-2-
yl]-4-methylpiperidine-1-carboxamide
306
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-1-methyl-1H-
pyrazole-4-carboxamide
307
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-1-(2-
methoxyethyl)-1H-pyrazole-4-carboxamide
308
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-2-methyl-1,3-
oxazole-5-carboxamide
309
N4-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-N1,N1-
dimethylbenzene-1,4-dicarboxamide
310
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-8-oxa-2-
azaspiro[4.5]decane-2-carboxamide
311
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-4-[(2-
oxopyrrolidin-1-yl)methyl]benzamide
312
N1-(2-hydroxyethyl)-N4-(4-methoxy-7-phenyl-1H-1,3-benzodiazol-
2-yl)benzene-1,4-dicarboxamide
313
N4-[7-methoxy-4-(1,4-oxazepan-4-yl)-1H-1,3-benzodiazol-2-yl]-
N1,N1-dimethylbenzene-1,4-dicarboxamide
314
N-[4-(3,6-dihydro-2H-pyran-4-yl)-7-methoxy-1H-1,3-benzodiazol-
2-yl]cyclopropanecarboxamide
315
N-[7-methoxy-4-(pyridin-3-yl)-1H-1,3-benzodiazol-2-
yl]cyclopropanecarboxamide
316
N4-[4-(4-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-
N1,N1-dimethylbenzene-1,4-dicarboxamide
317
4-(2,5-dioxopyrrolidin-1-yl)-N-[4-(4-fluorophenyl)-7-methoxy-1H-
1,3-benzodiazol-2-yl]benzamide
318
N-[4-(4-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-1-
methyl-1H-pyrazole-4-carboxamide
319
N4-[4-(2,6-dimethoxypyridin-3-yl)-7-methoxy-1H-1,3-benzodiazol-
2-yl]-N1,N1-dimethylbenzene-1,4-dicarboxamide
320
N-[4-(2,6-dimethoxypyridin-3-yl)-7-methoxy-1H-1,3-benzodiazol-
2-yl]cyclopropanecarboxamide
321
N-[7-methoxy-4-(pyridin-3-yl)-1H-1,3-benzodiazol-2-yl]-2-methyl-
1,3-oxazole-5-carboxamide
322
N-[4-(2,5-dihydrofuran-3-yl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-
2-methyl-1,3-oxazole-5-carboxamide
323
N-[4-(4-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-2-
methyl-1,3-oxazole-5-carboxamide
324
N4-[4-(3,6-dihydro-2H-pyran-4-yl)-7-methoxy-1H-1,3-benzodiazol-
2-yl]-N1,N1-dimethylbenzene-1,4-dicarboxamide
325
N-[4-(3,6-dihydro-2H-pyran-4-yl)-7-methoxy-1H-1,3-benzodiazol-
2-yl]-1-methyl-1H-pyrazole-4-carboxamide
326
(4-{2-[(4-hydroxy-4-methylpiperidine-1-carbonyl)amino]-7-
methoxy-1H-1,3-benzodiazol-4-yl}morpholin-2-yl)methyl
carbamate
327
(1-{2-[(4-hydroxy-4-methylpiperidine-1-carbonyl)amino]-7-
methoxy-1H-1,3-benzodiazol-4-yl}piperidin-3-yl)methyl cyanate
328
(1-{2-[(4-hydroxy-4-methylpiperidine-1-carbonyl)amino]-7-
methoxy-1H-1,3-benzodiazol-4-yl}piperidin-3-yl)methyl
carbamate
329
N-(7-methoxy-4-phenyl-1H-1,3-benzodiazol-2-yl)-2-oxa-8-
azaspiro[4.5]decane-8-carboxamide
330
N-[4-(1H-indol-6-yl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-1H-
imidazole-4-carboxamide
331
N-[4-(1H-indol-6-yl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-1-
methyl-1H-pyrazole-4-carboxamide
332
N-[4-(4-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-8-oxa-
2-azaspiro[4.5]decane-2-carboxamide
333
N-[4-(3,6-dihydro-2H-pyran-4-yl)-7-methoxy-1H-1,3-benzodiazol-
2-yl]-8-oxa-2-azaspiro[4.5]decane-2-carboxamide
334
N-[4-(3,6-dihydro-2H-pyran-4-yl)-7-methoxy-1H-1,3-benzodiazol-
2-yl]-4-[(2-oxopyrrolidin-1-yl)methyl]benzamide
335
N-[4-(4-fluorophenyl)-7-methoxy-1H-1,3-benzodiazol-2-yl]-4-[(2-
oxopyrrolidin-1-yl)methyl]benzamide
336
N-[4-(1H-indol-6-yl)-7-methoxy-1H-1,3-benzodiazol-2-
yl]cyclopropanecarboxamide
and physiologically acceptable salts, solvates, prodrugs and stereoisomers thereof, including mixtures thereof in all ratios.
8 . (canceled)
9 . (canceled)
10 . (canceled)
11 . (canceled)
12 . (canceled)
13 . (canceled)
14 . A method for the treatment and/or prophylaxis of physiological and/or pathophysiological states in a host in need thereof, comprising administering to said host an effective amount of a medicament comprising at least one compound of the formula I,
wherein
Q, Y are independently of one another CH or N,
R 1 is Hal or linear or branched alkyl having 1-10 C atoms which is unsubstituted or mono-, di- or trisubstituted by R 4 and in which 1-4 C atoms may be replaced, independently of one another, by O, S, SO, SO 2 , NH, NCH 3 , —OCO—, —NHCONH—, —NHCO—, —NR 5 SO 2 R 6 —, —COO—, —CONH—, —NCH 3 CO—, —CONCH 3 —, —C≡C— groups and/or —CH═CH— groups, and/or, in addition, 1-10 H atoms may be replaced by F and/or Cl, or mono- or bicyclic cyclic alkyl having 3-7 C atoms which is unsubstituted or mono-, di- or trisubstituted by R 4 and in which 1-4 C atoms may be replaced, independently of one another, by O, S, SO, SO 2 , NH, NCH 3 , —OCO—, —NHCONH—, —NHCO—, —NR 5 SO 2 R 6 —, —COO—, —CONH—, —NCH 3 CO—, —CONCH 3 —, —C≡C— groups and/or by —CH═CH— groups and/or, in addition, 1-10 H atoms may be replaced by F and/or Cl, or mono- or bicyclic heteroaryl, heterocyclyl, aryl or cyclic alkylaryl, containing 3 to 14 carbon atoms and 0-4 heteroatoms, independently selected from N, O and S, which is unsubstituted or mono-, di- or trisubstituted by R 4 ,
R 2 is linear or branched alkyl having 1-10 C atoms which is unsubstituted or mono-, di- or trisubstituted by R 4 and in which 1-4 C atoms may be replaced, independently of one another, by O, S, SO, SO 2 , NH, NCH 3 , —OCO—, —NHCONH—, —NHCO—, —NR 5 SO 2 R 6 —, —COO—, —CONH—, —NCH 3 CO—, —CONCH 3 —, —C≡C— groups and/or —CH═CH— groups, and/or, in addition, 1-10 H atoms may be replaced by F and/or Cl, or cyclic alkyl having 3-7 C atoms which is unsubstituted or mono-, di- or trisubstituted by R 4 and in which 1-4 C atoms may be replaced, independently of one another, by O, S, SO, SO 2 , NH, NCH 3 , —OCO—, —NHCONH—, —NHCO—, —NR 5 SO 2 R 6 —, —COO—, —CONH—, —NCH 3 CO—, —CONCH 3 —, —C≡C— groups and/or by —CH═CH— groups and/or, in addition, 1-11 H atoms may be replaced by F and/or Cl, or mono- or bicyclic heteroaryl, heterocyclyl, aryl or cyclic alkylaryl, containing 3 to 14 carbon atoms and 0-4 heteroatoms, independently selected from N, O and S, which is unsubstituted or mono-, di- or trisubstituted by R 4 ,
R 3 is linear or branched alkyl or O-alkyl having 1-6 C atoms or cyclic alkyl having 3-6 C atoms, which is unsubstituted or mono-, di- or trisubstituted by H, ═S, ═NH, ═O, OH, cyclic alkyl having 3-6 C atoms, COOH, Hal, NH 2 , SO 2 CH 3 , SO 2 NH 2 , CN, CONH 2 , NHCOCH 3 , NHCONH 2 or NO 2 ,
R 4 is H, R 5 , ═S, ═NR 5 , =0, OH, COOH, Hal, NH 2 , SO 2 CH 3 , SO 2 NH 2 , CN, CONH 2 , NHCOCH 3 , NHCONH 2 , NO 2 , or linear or branched alkyl having 1-10 C atoms which is unsubstituted or mono-, di- or trisubstituted by R 5 and in which 1-4 C atoms may be replaced, independently of one another, by O, S, SO, SO 2 , NH, NCH 3 , —OCO—, —NHCONH—, —NHCO—, —NR 5 SO 2 R 6 —, —COO—, —CONH—, —NCH 3 CO—, —CONCH 3 —, —C≡C— groups and/or —CH═CH— groups, and/or, in addition, 1-10 H atoms may be replaced by F and/or Cl, or mono- or bicyclic cyclic alkyl having 3-7 C atoms which is unsubstituted or mono-, di- or trisubstituted by R 5 and in which 1-4 C atoms may be replaced, independently of one another, by O, S, SO, SO 2 , NH, NCH 3 , —OCO—, —NHCONH—, —NHCO—, —NRSO 2 R 4 —, —COO—, —CONH—, —NCH 3 CO—, —CONCH 3 —, —C≡C— groups and/or by —CH═CH— groups and/or, in addition, 1-10 H atoms may be replaced by F and/or Cl, or mono- or bicyclic heteroaryl, heterocyclyl, aryl or cyclic alkylaryl, containing 3 to 14 carbon atoms and 0-4 heteroatoms, independently selected from N, O and S, which is unsubstituted or mono-, di- or trisubstituted by R 5 ,
R 5 , R 6 are independently of one another selected from the group consisting of H, ═S, ═NH, ═O, OH, COOH, Hal, NH 2 , SO 2 CH 3 , SO 2 NH 2 , CN, CONH 2 , NHCOCH 3 , NHCONH 2 , NO 2 and linear or branched alkyl having 1-10 C atoms in which 1-4 C atoms may be replaced, independently of one another, by O, S, SO, SO 2 , NH, NCH 3 , —OCO—, —NHCONH—, —NHCO—, —COO—, —CONH—, —NCH 3 CO—, —CONCH 3 —, —C≡C— groups and/or —CH═CH— groups, and/or, in addition, 1-10 H atoms may be replaced by F and/or Cl,
Hal is F, C, Br, or I,
and/or one of its physiologically acceptable salts, derivatives, solvates, prodrugs and stereoisomers, including mixtures thereof in all ratios.
15 . The method according to claim 14 , wherein the physiological states are hyperproliferative or infectious diseases or disorders.
16 . The method according to claim 15 , wherein the hyperproliferative disease or disorder is cancer.
17 . The method according to claim 16 , wherein the cancer is acute or chronic lymphocytic leukemia, acute granulocytic leukemia, adrenal cortex cancer, bladder cancer, brain cancer, breast cancer, cervical cancer, cervical hyperplasia, cervical cancer, chorio cancer, chronic granulocytic leukemia, chronic lymphocytic leukemia, colon cancer, endometrial cancer, esophageal cancer, essential thrombocytosis, genitourinary carcinoma, glioma, glioblastoma, hairy cell leukemia, head and neck carcinoma, Hodgkin's disease, Kaposi's sarcoma, lung carcinoma, lymphoma, malignant carcinoid carcinoma, malignant hypercalcemia, malignant melanoma, malignant pancreatic insulinoma, medullary thyroid carcinoma, melanoma, multiple myeloma, mycosis fungoides, myeloid and lymphocytic leukemia, neuroblastoma, non-Hodgkin's lymphoma, non-small cell lung cancer, osteogenic sarcoma, ovarian carcinoma, pancreatic carcinoma, polycythemia vera, primary brain carcinoma, primary macroglobulinemia, prostatic cancer, renal cell cancer, rhabdomyosarcoma, skin cancer, small-cell lung cancer, soft-tissue sarcoma, squamous cell cancer, stomach cancer, testicular cancer, thyroid cancer or Wilms' tumor.
18 . The method according to claim 15 , wherein the hyperproliferative disease or disorder is selected from the group consisting of age-related macular degeneration, Crohn's disease, cirrhosis, chronic inflammatory-related disorders, proliferative diabetic retinopathy, proliferative vitreoretinopathy, retinopathy of prematurity, granulomatosis, immune hyperproliferation associated with organ or tissue transplantation an immunoproliferative disease or disorder that is inflammatory bowel disease, psoriasis, rheumatoid arthritis, systemic lupus erythematosus (SLE), vascular hyperproliferation secondary to retinal hypoxia or vasculitis.
19 . The method according to claim 15 , wherein the infectious disease or disorder is
a) virally induced infectious diseases which are caused by retroviruses, hepadnaviruses, herpesviruses, flaviviridae and/or adenoviruses wherein the retroviruses are lentiviruses or oncoretroviruses, wherein the lentivirus is HIV-1, HIV-2, FIV, BIV, SIVs, SHIV, CAEV, VMV or EIAV and the oncoretrovirus HTLV-I, HTLV-II or BLV, the hepadnavirus is HBV, GSHV or WHV, the herpesivirus is HSV I, HSV II, EBV, VZV, HCMV or HHV 8 and the flaviviridae is HCV, West nile or Yellow Fever,
b) bacterial infectious diseases which are caused by Gram-positive bacteria wherein the Gram-positive bacteria are of methicillin-susceptible or methicillin-resistant staphylococci that are Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus , or coagulase-negative staphylococci, glycopeptides-intermediate susceptible Staphylococcus aureus (GISA), penicillin-susceptible or penicillin-resistant streptococci that are Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus avium, Streptococcus bovis, Streptococcus lactis, Streptococcus sanguis or Streptococci Group C (GCS), Streptococci Group G (GGS) or viridans streptococci, enterococci that are vancomycin susceptible or vancomycin-resistant strains that are Enterococcus faecalis or Enterococcus faecium, Clostridium difficile, Listeria monocytogenes, Corynebacterium jeikeium, Chlamydia spp or Mycobacterium tuberculosis,
c) bacterial infectious diseases which are caused by Gram-negative bacteria wherein the Gram-negative bacteria are of the Genus Enterobacteriacae, Klebsiella spp., Enterobacter spp., Citrobacter spp., Serratia spp., Proteus spp., Providencia spp., Salmonella spp., Shigella spp., the genus Pseudomonas, Moraxella spp. Haemophilus spp. or Neisseria spp.,
d) infectious diseases induced by intracellular active parasites of phylum Apicomplexa, or Sarcomastigophora that are Trypanosoma, Plasmodia, Leishmania, Babesia or Theileria , Cryptosporidia, Sacrocystida, Amoebia, Coccidia or Trichomonadia.
20 . (canceled)