Systems and methods for controlling blood pressure

1. A system for therapeutic application of energy to nerves within a patient, comprising:

a wearable interface configured to at least partially encircle a first portion of a first limb of a subject; and

an energy applicator carried by the wearable interface and configured to apply electrical stimulation energy and vibrational energy to a nerve within the first limb of the subject, wherein the energy applicator comprises:

a flexible substrate having a first surface configured to face toward the first limb of the subject and a second surface opposite the first surface;

a first electrode carried substantially on the first surface of the flexible substrate and configured as a source of the electrical stimulation energy; and

a first piezoelectric carried substantially on the second surface of the flexible substrate and configured as a source of the vibrational energy;

wherein the first electrode and the first piezoelectric are overlaid to comprise a first layered pair.

2. The system of claim 1 , wherein the first electrode and the first piezoelectric can be operated in unison.

3. The system of claim 1 , further comprising:

a controller carried by the wearable interface and configured to operate the energy applicator.

4. The system of claim 1 , wherein the flexible substrate comprises polyimide.

5. The system of claim 1 , wherein the first electrode comprises a conductive hydrogel.

6. The system of claim 1 , wherein the first piezoelectric comprises PZT.

7. The system of claim 1 , wherein the flexible substrate further comprises a conductive trace carried on the first surface, and wherein the first electrode is electrically coupled to the conductive trace.

8. The system of claim 7 , wherein the first electrode is electrically coupled to the conductive trace with a conductive ink.

9. The system of claim 8 , wherein the conductive ink comprises one or more material selected from the list consisting of: silver-silver chloride, copper, and gold.

10. The system of claim 1 , wherein the piezoelectric comprises a disc.

11. The system of claim 1 , wherein the flexible substrate further comprises a conductive trace carried on the second surface, and wherein the first piezoelectric is electrically coupled to the conductive trace with a conductive epoxy.

12. The system of claim 1 , further comprising:

a sensor carried by the wearable interface and configured to be in proximity of the first portion of the first limb of the subject and to output a signal for determining at least a change in blood pressure of the subject at the first limb.

13. The system of claim 12 , wherein the sensor comprises a blood pressure sensor.

14. The system of claim 12 , wherein the sensor is configured to determine heart rate.

15. The system of claim 12 , wherein the sensor is configured to determine heart rate variability.

16. The system of claim 12 , wherein the sensor comprises an electrode for measuring electrocardiography data from the first limb of the subject.

17. The system of claim 1 , wherein the piezoelectric is configured to vibrate at a frequency of between about 20 kHZ and about 1 MHz.

18. The system of claim 1 , wherein the piezoelectric is configured to vibrate at a frequency of between about 20 kHZ and about 700 kHz.

19. The system of claim 1 , wherein the energy applicator comprises an array of layered pairs including the first layered pair and one or more additional layered pairs, each of the one or more additional layered pairs comprising an electrode coupled to the first surface of the flexible substrate and a piezoelectric coupled to the second surface of the flexible substrate.

20. The system of claim 19 , wherein at least one electrode of the array of layered pairs can be operated independently of its paired piezoelectric.