Granted Patent B2

US 12,691,260 · App. 17/719,032 · Granted Jul 28, 2026

Inventors: Lixiao Wang (Henderson, NV); John J. Chen (Plymouth, MN); Yongxing Zhang (Irvine, CA)

Assignee: Neurotronic, Inc.

A61M25/1002A61B18/06A61K31/045A61M5/007A61M5/142A61M5/172A61M25/1011A61M29/02A61B2018/00577A61M2025/105A61M2025/1052A61M2202/02

Abstract

Claims (45)

1 . A method for treating a body lumen, the method comprising:

inserting a first balloon delivery catheter into a first treatment site in a splenic artery, a hepatic artery, a common hepatic artery, a hepatic celiac artery, a left hepatic artery, a right hepatic artery, a proper hepatic artery, a renal artery, a main renal artery, a main renal branch artery, an extra-renal artery, or an extra-renal branch artery;

inflating the first balloon delivery catheter;

infusing a chemical formulation and/or delivering energy from the first balloon delivery catheter to a tissue of the body lumen at the first treatment site, wherein the chemical formulation infused and/or the energy delivered is effective to injure and/or damage the tissue at the first treatment site;

deflating the first balloon delivery catheter;

withdrawing the first balloon delivery catheter from the first treatment site;

inserting a second balloon delivery catheter that is the same or different as the first balloon delivery catheter into a second treatment site in a splenic artery, a hepatic artery, a common hepatic artery, a hepatic celiac artery, a left hepatic artery, a right hepatic artery, a proper hepatic artery, a renal artery, a main renal artery, a main renal branch artery, an extra-renal artery, or an extra-renal branch artery, wherein the second treatment site is a different treatment site than the first treatment site;

inflating the second balloon delivery catheter;

infusing a chemical formulation and/or delivering energy from the second balloon delivery catheter to a tissue of the body lumen at the second treatment site, wherein the chemical formulation infused and/or the energy delivered is effective to injure and/or damage the tissue at the second treatment site;

deflating the second balloon delivery catheter; and

withdrawing the second balloon delivery catheter from the second treatment site.

2 . The method of claim 1 , wherein the injury and/or damage to the tissue at the first treatment site and to the tissue at the second treatment site is effective to have a benefit of reduction of body weight, reduction of HbA1c (A1c) and/or glucose level, reducing blood pressure, or a combination thereof.

3 . The method of claim 1 , wherein the injury and/or damage to the tissue at the first treatment site and to the tissue at the second treatment site is effective to have a benefit of reduction of body weight.

4 . The method of claim 1 , wherein the injury and/or damage to the tissue at the first treatment site and to the tissue at the second treatment site is effective to have a benefit of reduction of HbA1c (A1c) and/or glucose level.

5 . The method of claim 1 , wherein the injury and/or damage to the tissue at the first treatment site and to the tissue at the second treatment site is effective to have a benefit of reducing blood pressure.

6 . The method of claim 1 , wherein the method further comprises:

inserting a third balloon delivery catheter that is the same or different as the first or second balloon delivery catheter into a third treatment site in a splenic artery, a hepatic artery, a common hepatic artery, a hepatic celiac artery, a left hepatic artery, a right hepatic artery, a proper hepatic artery, a renal artery, a main renal artery, a main renal branch artery, an extra-renal artery, or an extra-renal branch artery, wherein the third treatment site is a different treatment site than the first and second treatment site;

inflating the first balloon delivery catheter;

infusing a chemical formulation and/or delivering energy from the third balloon delivery catheter to a tissue of the body lumen at the third treatment site, wherein the chemical formulation infused and/or the energy delivered is effective to injure and/or damage the tissue at the third treatment site;

deflating the third balloon delivery catheter; and

withdrawing the third balloon delivery catheter from the third treatment site.

7 . The method of claim 6 , wherein the injury and/or damage to the tissue at the first, second, and third treatment sites is effective to have a benefit of reduction of body weight, reduction of HbA1c (A1c) and/or glucose level, reducing blood pressure, or a combination thereof.

8 . The method of claim 6 , wherein the injury and/or damage to the tissue at the first, second, and third treatment sites is effective to have a benefit of reduction of body weight.

9 . The method of claim 6 , wherein the injury and/or damage to the tissue at the first, second, and third treatment sites is effective to have a benefit of reduction of HbA1c (A1c) and/or glucose level.

10 . The method of claim 6 , wherein the injury and/or damage to the tissue at the first, second, and third treatment sites is effective to have a benefit of reducing blood pressure.

11 . The method of claim 1 , wherein the method comprises infusing the chemical formulation from the first and/or second delivery catheter to the tissue of the body lumen at the first and/or second treatment site.

12 . The method of claim 11 , wherein the chemical formulation comprises ethanol, acetic acid, ethanol and water, an ethanol/water azeotrope, or ethanol and acetic acid.

13 . The method of claim 11 , wherein the chemical formulation comprises ethanol.

14 . The method of claim 1 , wherein the method comprises delivering energy from the first and/or second delivery catheter to the tissue of the body lumen at the first and/or second treatment site.

15 . The method of claim 14 , wherein the energy is chosen from radiofrequency, cryoablation, microwave, laser, ultrasound, high intensity focused ultrasound, and combinations thereof.

16 . The method of claim 14 , wherein the energy comprises radiofrequency energy.

17 . The method of claim 14 , wherein the energy comprises ultrasound energy.

18 . The method of claim 14 , wherein the energy comprises vapor condensation of at least some of the chemical formulation to a liquid.

19 . The method of claim 14 , wherein the first and second balloon delivery catheter comprises an energy delivery catheter for delivery of energy comprising radiofrequency, cryoablation, microwave, laser, ultrasound, high intensity focused ultrasound, and combinations thereof.

20 . The method of claim 1 , wherein the first and/or second balloon delivery catheter comprises a needle catheter or a needle-based catheter.

21 . The method of claim 20 , wherein the needle-based balloon delivery catheter comprises:

a proximal end;

a distal end;

a wire lumen;

a formulation infusion lumen and/or a vacuum lumen; and

a flushing port.

22 . The method of claim 20 , wherein the formulation is delivered into the body lumen wall.

23 . The method of claim 1 , further comprising flushing the first and/or second treatment sites with saline or water.

24 . The method of claim 1 , further comprising flushing the first and/or second balloon delivery catheter with saline or water.

25 . The method of claim 1 , wherein the method is a method of treating a disease, wherein the disease comprises diabetes, obesity, hypertension, or a combination thereof.

Assignments (1)

Continuity (12)

References Cited (400)