Methods of treating dyskinesia and related disorders
The present disclosure describes compounds and pharmaceutically acceptable salts thereof and compositions and formulations comprising the same that are useful in methods of treating dyskinesia or related disorders, and methods for treating dyskinesia or related disorders.
1. A composition comprising:
a) sydnocarb; and
b) another therapeutic agent used to treat dyskinesias or an anti-psychotic agent that induces dyskinesias.
2. The composition of claim 1 , wherein the therapeutic agent used to treat dyskinesias is chosen from a glutamate receptor antagonist, an AMPA receptor, a mGluR5, a glutamate release inhibitor, an opioid, a serotonergic agent, a GABA compound, an adenosine compound, a cannabinioid, an adrenergic, a histamine, tamoxifen, sildenafil, and 3-ethyl-5-(5-((4-ethylpiperazino)sulphonyl)-2-propoxyphenyl)-2-(2-pyridylmethyl)-6,7-dihydro-2H-pyrazolo(4,3-d)pyrimidin-7-one (Uk-343,664).
3. The composition of claim 2 , wherein the glutamate receptor antagonist is amantadine, dextrorphan, dextromorphan, dizocilpine (MK-801), or 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol (Co-101,244/PD-174,494).
4. The composition of claim 2 , wherein the AMPA receptor is retigabine, flupirtine, topirimate, benzenamine, 4-(8-chloro-2-methyl-11H-imidazo(1,2-C)(2,3)benzodiazepin-6-yl)-(GYK-47,261), or 5-(1-Adamantylmethylamino)pentyl-trimethylazanium; bromide; hydrobromide (IEM-1460).
5. The composition of claim 2 , wherein the mGluR5 is 6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one (MRZ-8676), mavoglurant (AFQ056), dipraglurant (ADX-48,621), 2-Methyl-6-(phenylethynyl)pyridine, or 3-((2-Methyl-4-thiazolyl)ethynyl)pyridine.
6. The composition of claim 2 , wherein the glutamate release inhibitor is riluzole or naftazone.
7. The composition of claim 2 , wherein the opioid is trans-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide (U50-488), morphine, meperidine, or methadone.
8. The composition of claim 2 , wherein the serotonergic agent is buspirone, clozapine, quetiapine, 3,4-methylenedioxy-N-methamphetamine, pimavenserin, ritanserin, citalopram, or fluoxetine.
9. The composition of claim 2 , wherein the GABA compound is diazepam or zolpidem.
10. The composition of claim 2 , wherein the adenosine compound is istradefylline or preladenant.
11. The composition of claim 2 , wherein the cannabinioid is rimonabant or nabilone.
12. The composition of claim 2 , wherein the adrenergic is idazoxan, yohimbine, rauwolscine, fipamezole, or propranolol.
13. The composition of claim 2 , wherein the histamine is famotidine, immepip, or imetit.
14. The composition of claim 1 , wherein the anti-psychotic agent is chlorpromazine, metoclopramide, promethazine, olanzapine, risperidone, clozapine, or aripiprazole.