Pinch to open sample collection device
A blood sample collection and/or storage device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect the sample for storage and optionally process the sample within the housing. The housing may also be opened to access the stored sample for further processing.
1. A method comprising:
providing a device comprising:
a housing configurable from a first position to a second position;
a sample collection port configured to collect the biological sample when the housing is in the first position and to be inaccessible when the housing is in the second position;
one or more fluid pathways configured to receive the biological sample from the sample collection port; and
a mechanical actuator comprising one or more plungers configured to be inserted into the one or more fluid pathways,
wherein,
the sample collection port configured to comprise a biological sample,
the housing is configured to be transitioned from the first position to the second position, thereby causing the one or more plungers to be inserted into the one or more fluid pathways and rendering the sample collection port inaccessible,
the one or more plungers are configured to push at least a portion of the biological sample from the sample collection port into the one or more fluid pathways when transitioning the housing from the first position to the second position; and
transitioning the housing from at least one of the first position to the second position and the second position to the first position.
2. The method of claim 1 , the device further comprising one or more reagents configured to treat the biological sample.
3. The method of claim 2 , wherein the one or more reagents comprises a fluid stabilization reagent, a preservative, or combinations thereof.
4. The method of claim 2 , wherein the one or more fluid pathways further comprise the one or more reagents configured to treat the biological sample upon contacting the one or more fluid pathways.
5. The method of claim 4 , wherein the one or more reagents comprises heparin.
6. The method of claim 2 , wherein the one or more reagents comprises a sugar.
7. The method of claim 1 , wherein the device is configured to separate cellular material from the biological sample.
8. The method of claim 1 , wherein the device further comprises a membrane disposed within the housing configured to separate cellular material from the biological sample.
9. The method of claim 8 , wherein the device is configured to treat the biological sample with one or more reagents upon contacting the membrane.
10. The method of claim 8 , wherein the membrane is configured to stabilize the biological sample on the membrane.
11. The method of claim 1 , wherein the device is configured to dry the biological sample.
12. The method of claim 1 , wherein the device further comprises a desiccant configured to dry the biological sample by removing moisture from the biological sample.
13. The method of claim 1 , wherein the housing defines an isolated internal air space in the second position.
14. The method of claim 1 , wherein the device is configured to move the biological sample from the sample collection port to the one or more fluid pathways.
15. The method of claim 14 , wherein the device is configured to move the biological sample from the sample collection port to the one or more fluid pathways by capillary action.
16. The method of claim 1 , wherein the one or more fluid pathways are visible to a user when the housing is in the first position.
17. The method of claim 1 , further comprising verifying the movement of the biological sample from the sample collection port to the one or more fluid pathways by viewing the biological sample in the one or more fluid pathways prior to transitioning the device from the first position to the second position.
18. The method of claim 1 , further comprising inserting two or more plungers into two or more fluid pathways.
19. The method of claim 1 , wherein the device is configured to lock the housing in the second position upon transitioning the device from the first position to the second position.
20. The method of claim 1 , further comprising transporting the device to a remote facility for processing of the biological sample.
21. The method of claim 1 , wherein at least a portion of each of the one or more plungers is positioned external to the one or more fluid passageways when the housing is in the first position.
22. A method comprising:
receiving a device comprising:
a housing configurable from a first position to a second position;
a sample collection port configured to collect the biological sample when the housing is in the first position and to be inaccessible when the housing is in the second position;
one or more fluid pathways configured to receive the biological sample from the sample collection port; and
a mechanical actuator comprising one or more plungers configured to be inserted into the one or more fluid pathways,
wherein,
the sample collection port configured to comprise a biological sample,
the housing is configured to be transitioned from the first position to the second position, thereby causing the one or more plungers to be inserted into the one or more fluid pathways and rendering the sample collection port inaccessible, and
the one or more plungers are configured to push at least a portion of the biological sample from the sample collection port into the one or more fluid pathways when transitioning the housing from the first position to the second position; and
transitioning the housing from at least one of the first position to the second position and the second position to the first position.