Bioenergetically active esters for health and disease
Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and compositions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.
1. A pharmaceutical composition comprising
a compound of Formula I
or a pharmaceutically acceptable salt and/or solvate thereof, wherein both R 1 and R 2 are
and
a pharmaceutically acceptable carrier.
2. A pharmaceutical composition comprising
an effective amount of a compound of Formula I
or a pharmaceutically acceptable salt and/or solvate thereof, wherein both R 1 and R 2 are
and
a pharmaceutically acceptable carrier.
3. The pharmaceutical composition of claim 2 , wherein the effective amount is an amount of the compound effective to increase cellular respiration and/or glycolytic flux in a subject.
4. The pharmaceutical composition of claim 2 , wherein the effective amount is an amount effective to treat a neurodegenerative disease in a subject.
5. The pharmaceutical composition of claim 2 , wherein the effective amount is an amount effective to treat Alzheimer's disease in a subject.
6. The pharmaceutical composition of claim 2 , wherein the effective amount is an amount effective to treat Parkinson's disease in a subject.
7. The pharmaceutical composition of claim 2 , wherein the effective amount is an amount effective to treat amyotrophic lateral sclerosis in a subject.
8. The pharmaceutical composition of claim 2 , wherein the effective amount is an amount effective to treat multiple sclerosis in a subject.
9. The pharmaceutical composition of claim 2 , wherein the effective amount is an amount effective to treat epilepsy in a subject.
10. The pharmaceutical composition of claim 2 , wherein the effective amount is an amount effective to treat a mitochondrial disorder in a subject.
11. The pharmaceutical composition of claim 2 , wherein the effective amount is an amount effective to improve athletic performance in a subject.
12. The pharmaceutical composition of claim 2 , wherein the effective amount is an amount effective to improve cognitive performance in a subject.
13. A method for increasing cellular respiration in a cell, the method comprising contacting the cell with a compound of Formula I
or a pharmaceutically acceptable salt and/or solvate thereof, wherein both R 1 and R 2 are
14. The method of claim 13 , wherein the cell is a neuronal cell.