Fc VARIANTS WITH ALTERED BINDING TO FcRn
The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
1 .- 7 . (canceled)
8 . In a method of treating a patient by administering an anti-C5 antibody with an Fc domain, the improvement comprising said Fc domain comprising amino acid substitutions M428L/N434A as compared to a human Fc polypeptide, wherein numbering is according to the EU index in Kabat et al.
9 . In a method of treating a patient by administering an anti-C5 antibody with an Fc domain, the improvement comprising said Fc domain comprising amino acid substitutions M428L/N434A as compared to a human Fc polypeptide, wherein numbering is according to the EU index in Kabat et al., wherein said anti-C5 antibody with said amino acid substitutions has increased in vivo half-life as compared to said antibody without said substitutions.
10 . A polypeptide comprising a variant human IgG Fc region comprising amino acid substitutions M428L/N434A, wherein said numbering is according to the EU index in Kabat et al.