IP Library › Granted Patent US 12,571,052
Granted Patent B2
US 12,571,052 · App. 17/749,039 · Granted Mar 10, 2026

Immunomodulatory RNA

Inventors: Andy J. Minn (Philadelphia, PA); Barzin Y. Nabet (Menlo Park, CA); Lexus R. Johnson (Philadelphia, PA)
Assignee: The Trustees of the University of Pennsylvania
C12Q1/6886A61K31/7105A61K45/06A61P35/00C12N15/117C12N2310/14C12N2310/17C12N2310/20C12N2330/10C12Q2600/118C12Q2600/158
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Quick Facts
Patent No.
US 12,571,052
App. No.
17/749,039
Granted
Mar 10, 2026
Kind
B2
Abstract

The present invention includes methods for detecting cancer in a subject and measuring the effectiveness of a cancer treatment. In certain embodiments, the invention includes assessing the level of unshielded RN7SL1 RNA in a sample from a subject.

Claims (7)

1 . A method of treating a cancer in a subject in need thereof, the method comprising, administering to the subject a therapeutically effective amount of an unshielded RN7SL1 RNA in combination with a CSF1R inhibitor and one or more immune checkpoint blocker(s),

wherein the one or more immune checkpoint blocker(s) comprise an anti-PD-1 antibody and/or an anti-CTLA-4 antibody, and

wherein the cancer is melanoma or pancreatic adenocarcinoma.

2 . The method of claim 1 , wherein the CSF1R inhibitor is an anti-CSF1R antibody or a small molecule inhibitor of CSF1R.

3 . The method of claim 1 , wherein the CSF1R inhibitor is BLZ945.

4 . The method of claim 1 , wherein the unshielded RN7SL1 RNA is administered to the tumor microenvironment of the subject.

5 . The method of claim 1 , wherein the RN7SL1 RNA comprises the RNA sequence of SEQ ID NO: 2.

Assignments (2)
CONFIRMATORY LICENSE Recorded Sep 5, 2024
From: UNIVERSITY OF PENNSYLVANIA
To: UNITED STATES GOVERNMENT
Reel/Frame 068840/0077 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 22, 2022
From: MINN, ANDY J.; NABET, BARZIN Y.; JOHNSON, LEXUS R.
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 060274/0935 →
Continuity (5)
Continuation 17476342 · Sep 15, 2021
Continuation 15947526 · Apr 6, 2018
Provisional Application 62614610 · Jan 8, 2018
Provisional Application 62483082 · Apr 7, 2017
Related Publication 20230121917A1 · Apr 20, 2023
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