IP Library › Granted Patent US 12,226,604
Granted Patent B2
US 12,226,604 · App. 17/749,061 · Granted Feb 18, 2025

Dual pathway therapeutic agent delivery

Inventors: Aravind Arepally (Atlanta, GA); James E. Chomas (Denver, CO); David Benjamin Jaroch (Arvada, CO); Patrick Charles McCain (Denver, CO)
Assignee: TriSalus Life Sciences, Inc.
A61M31/002A61M25/0026A61M5/14276A61M39/0208
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Quick Facts
Patent No.
US 12,226,604
App. No.
17/749,061
Granted
Feb 18, 2025
Kind
B2
Abstract

Methods are provided for delivering a treatment therapy to treat an organ diagnosed with a disease state. The methods include delivering a first therapeutic agent into systemic circulation at a first flow rate, and delivering a second therapeutic agent directly into a vessel feeding the organ at a higher second flow rate than the first flow rate in a manner that prevents the second treatment agent from circulating systemically.

Claims (44)

1. A method of delivering a treatment therapy to a patient, the treatment therapy to treat an organ diagnosed with a disease state, comprising:

a) delivering a first therapeutic agent into systemic circulation at a first flow rate; and

b) delivering a second therapeutic agent directly into or adjacent a vessel extending from the organ at a higher second flow rate than the first flow rate in a manner that provides targeted treatment of the organ.

2. The method according to claim 1 , wherein the disease state is a tumor.

3. The method according to claim 2 , wherein the organ is the pancreas.

4. The method according to claim 1 , wherein the first therapeutic agent is delivered into the superior vena cava, and the vessel is the portal vein.

5. The method according to claim 1 , further comprising preventing retrograde flow in the vessel of the organ during delivering the second therapeutic agent.

6. The method according to claim 5 , wherein retrograde flow is automatically and dynamically prevented.

7. The method according to claim 5 , wherein the retrograde flow is prevented by an occlusion device.

8. The method according to claim 1 , wherein the second therapeutic agent upon delivery is prevented from systemic circulation.

9. The method according to claim 1 , wherein the second therapeutic agent, upon delivery, is initially isolated in a target region.

10. The method according to claim 1 , further comprising before delivering the second therapeutic agent, monitoring a systemic pressure of the venous system, and adjusting the second flow rate based on the monitored systemic pressure.

11. The method according to claim 1 , wherein delivering the first and second therapeutic agents occur through separate catheters.

12. The method according to claim 1 , further comprising after delivering the second therapeutic agent, injecting a bolus of another liquid into the vessel to cause the second therapeutic agent to be pushed deeper into the organ.

13. The method according to claim 12 , wherein the bolus is saline.

14. A method of delivering a treatment therapy to a patient, the treatment therapy to treat an organ diagnosed with a disease state, comprising:

a) infusing a first therapeutic into systemic circulation at a first flow rate; and

b) injecting a second therapeutic agent directly into or adjacent a vessel extending from the organ at a higher second flow rate than the first flow rate in a manner that provides targeted treatment of the organ.

15. The method according to claim 14 , wherein the disease state is a tumor.

16. The method according to claim 14 , wherein the organ is the pancreas.

17. The method according to claim 14 , wherein the first therapeutic agent is infused into the superior vena cava, and the vessel is the portal vein.

18. The method according to claim 14 , further comprising preventing retrograde flow in the vessel of the organ during delivering the second therapeutic agent.

19. The method according to claim 18 , wherein retrograde flow is automatically and dynamically prevented.

20. The method according to claim 18 , wherein the retrograde flow is prevented by an occlusion device.

21. The method according to claim 14 , further comprising before injecting the second therapeutic agent, monitoring a systemic pressure of the venous system, and adjusting the second flow rate based on the monitored systemic pressure.

22. The method according to claim 14 , wherein the second therapeutic agent upon delivery is prevented from systemic circulation.

23. The method according to claim 14 , wherein the second therapeutic agent, upon delivery, is initially isolated in a target region.

24. The method according to claim 14 , wherein delivering the first and second therapeutic agents occur through separate catheters.

25. The method according to claim 14 , further comprising after injecting the second therapeutic agent, injecting a bolus of another liquid into the vessel to cause the second therapeutic agent to be pushed deeper into the organ.

26. The method according to claim 25 , wherein the bolus is saline.

27. A method of delivering a treatment therapy to a patient, the treatment therapy to treat an organ diagnosed with a disease state, comprising:

a) delivering a first therapeutic into systemic circulation at a first flow rate; and

b) delivering a second therapeutic agent directly into or adjacent a vessel extending from the organ at a higher second flow rate than the first flow rate, wherein retrograde flow in the vessel of the organ is prevented during the delivering of the second therapeutic agent.

28. The method according to claim 27 , wherein the disease state is a tumor.

29. The method according to claim 27 , wherein the organ is the pancreas.

30. The method according to claim 27 , wherein the first therapeutic agent is delivered into the superior vena cava, and the vessel is the portal vein.

31. The method according to claim 27 , wherein retrograde flow in the major vessel is automatically and dynamically prevented.

32. The method according to claim 27 , wherein the retrograde flow is prevented by an occlusion device.

33. The method according to claim 27 , further comprising before delivering the second therapeutic agent, monitoring a systemic pressure of the venous system, and adjusting the second flow rate based on the monitored systemic pressure.

34. The method according to claim 27 , wherein delivering the first and second therapeutic agents occur through separate catheters.

35. The method according to claim 27 , further comprising after delivering the second therapeutic agent, injecting a bolus of another liquid into the vessel to cause the second therapeutic agent to be pushed deeper into the organ.

36. The method according to claim 35 , wherein the bolus is saline.

37. The method according to claim 27 , wherein the second therapeutic agent upon delivery is prevented from systemic circulation.

38. The method according to claim 27 , wherein the second therapeutic agent, upon delivery, is initially isolated in a target region.

Assignments (1)
SECURITY INTEREST Recorded Apr 30, 2024
From: TRISALUS LIFE SCIENCES, INC.
To: ORBIMED ROYALTY & CREDIT OPPORTUNITIES IV, LP
Reel/Frame 067274/0733 →
Continuity (3)
Continuation 16405605 · May 7, 2019
Provisional Application 62742573 · Oct 8, 2018
Related Publication 20220273920A1 · Sep 1, 2022
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