In situ gelling self-reactive materials for embolization
View Patent ↗A method and composition for treating arteriovenous malformations (AVMs), or abnormal vasculature in the body are provided. The method comprises introducing into the region of an AVM a composition comprising a nucleophilic component, such as a thiol, and a component containing a conjugated unsaturated bond, such as an acrylate through a catheter, whereby the composition crosslinks within the body to block or occlude the AVM.
1. A method of embolizing a blood vessel or vascular malformation, comprising:
blocking blood flow in a blood vessel;
administering to the blood vessel or vascular malformation a composition comprising a nucleophilic component including pentaerythritol-tetrakis(3-mercaptopropionate) (QT) and a component containing a conjugated unsaturated bond including poly(propylene glycol)diacrylate; and
crosslinking, within the blood vessel or vascular malformation, the nucleophilic component with the component containing a conjugated unsaturated bond so as to form a crosslinked emboli and occlude the blood vessel or vascular malformation.
2. The method of claim 1 wherein the composition further comprises a buffer solution.
3. The method of claim 2 wherein the buffer is a phosphate buffer.
4. The method of claim 1 wherein the composition further comprises a surfactant.
5. The method of claim 1 wherein the composition further comprises a base.
6. The method of claim 5 wherein the base is NaOH.
7. The method of claim 1 wherein the composition gels within the blood vessel within 30 minutes of introduction.
8. The method of claim 1 wherein the composition gels within the blood vessel within 15 minutes of introduction.
9. The method of claim 1 wherein the composition further comprises at least one additional agent selected from the group consisting of radiopaque agents and nonsteroidal anti-inflammatory compounds.
10. The method of claim 1 further comprising a second thiole precursor.
11. The method of claim 10 wherein the second thiole precursor is dithiothreitol (DTT).
12. The method of claim 1 wherein the component containing a conjugated unsaturated bond consists of polypropylene glycol diacrylate (PPODA).
13. The method of claim 1 wherein the component containing a conjugated unsaturated bond further includes polyethylene glycol diacrylate (PEGDA).
14. The method of claim 1 wherein the component containing a conjugated unsaturated bond further includes pentaerythritol triacrylate (TA).
15. The method according to claim 1 further comprising increasing the pH of the composition prior to introducing the composition.
16. The method according to claim 1 wherein the composition is introduced into the blood vessel through a catheter.
17. The method according to claim 16 wherein the catheter is a balloon catheter.
18. The method according to claim 1 wherein the blood vessel for embolization has an arteriovenous malformation.