Compounds for the treatment of SARS
Bis-amide inhibitors of SARS-CoV-2 (COVID); pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
1. A compound of Formula (IIIb) or (IIIc):
wherein:
R 1a is alkyl; and
R 2a is —C(O)alkyl, —C(O)alkenyl, or —S(O) 2 -alkenyl;
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein R 1a is t-butyl.
3. The compound of claim 1 , wherein R 2a is
4. The compound of claim 1 , wherein R 2a is
5. The compound of claim 1 , wherein R 2a is
6. The compound of claim 1 , wherein the compound of formula (IIIb) is selected from
7. The compound of claim 1 , wherein the compound of formula (IIIc) is
8. The compound of claim 1 , wherein the compound of formula (IIIc) is
9. A pharmaceutical composition comprising a therapeutically effective amount of one or more compounds of claim 1 and at least one pharmaceutical acceptable carrier.