IP Library Granted Patent US 12,540,304
Granted Patent B2
US 12,540,304 · App. 17/762,392 · Granted Feb 3, 2026

Culturing apparatus setup method, assistance apparatus, and culturing apparatus

Inventor: Toyoshige Kobayashi (Tokyo, JP)
Assignee: HITACHI HIGH-TECH CORPORATION
C12M41/48C12M27/16G01N33/5005G01N35/00693
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Quick Facts
Patent No.
US 12,540,304
App. No.
17/762,392
Granted
Feb 3, 2026
Kind
B2
Abstract

According to the present invention, an initial-stage test apparatus-culturing condition (parameter set) is determined ( 22 ) on the basis of a manual culturing condition ( 26 ) for a specific cell. Multiple apparatus-culturing tests ( 20 ) are run in accordance with multiple test apparatus-culturing conditions, including the initial-stage test apparatus-culturing condition. A test apparatus-culturing condition at the time point when the result of an apparatus-culturing test satisfies requirement specifications is set ( 40 ) in a culturing apparatus as a setting apparatus-culturing condition, and the culturing apparatus is set up by using said setting apparatus-culturing condition.

Claims (28)

1 . A culturing apparatus setup method comprising:

an initial-stage determination step of determining an initial-stage test apparatus-culturing condition on a basis of a manual culturing condition found out by a manual culturing test;

a testing step of finding out a setting apparatus-culturing condition by running multiple apparatus-culturing tests using a test culturing apparatus with multiple test apparatus-culturing conditions including the initial-stage test apparatus-culturing condition set in the test culturing apparatus; and

a setting step of generating a customized culturing apparatus by setting the setting apparatus-culturing condition in a culturing apparatus, wherein

multiple culturing condition pairs are managed on a database,

the respective culturing condition pairs include a manual culturing condition found out in a past and an apparatus-culturing condition found out in a past on a basis of the manual culturing condition, and

the initial-stage test apparatus-culturing condition is determined through use of the database in the initial-stage determination step.

2 . The culturing apparatus setup method according to claim 1 , wherein

the manual culturing condition is a condition for culturing a specific cell by manual culture,

the respective apparatus-culturing conditions are conditions for culturing the specific cell by apparatus culture, and

the customized culturing apparatus is a dedicated culturing apparatus that cultures the specific cell.

3 . The culturing apparatus setup method according to claim 1 , wherein

cell information is assigned to each of the culturing condition pairs on the database, and

a culturing condition pair to be referred is selected from among the multiple culturing condition pairs registered in the database in accordance with specified cell information in the initial-stage determination step.

4 . The culturing apparatus setup method according to claim 3 , wherein

the found-out manual culturing condition is compared with a manual culturing condition in the culturing condition pair to be referred, and an apparatus-culturing condition in the culturing condition pair to be referred is referred to determine the initial-stage apparatus-culturing condition in the initial-stage determination step.

5 . The culturing apparatus setup method according to claim 1 , wherein

the manual culturing condition found out by the manual culturing test is registered in the database as a new manual culturing condition,

the apparatus-culturing condition found out by the apparatus-culturing tests is registered in the database as a new apparatus-culturing condition, and

the new manual culturing condition and the new apparatus-culturing condition constitute a new culturing condition pair.

6 . The culturing apparatus setup method according to claim 1 , wherein

a determination is made as to whether a result of an apparatus-culturing test satisfies requirement specifications for each of the apparatus-culturing tests in the testing step,

a test apparatus-culturing condition causing the result of the apparatus-culturing test is corrected to set a next test apparatus-culturing condition when the result of the apparatus-culturing test does not satisfy the requirement specifications, and

the test apparatus-culturing condition causing the result of the apparatus-culturing test is set as the setting apparatus-culturing condition when the result of the apparatus-culturing test satisfies the requirement specifications.

7 . The culturing apparatus setup method according to claim 6 , wherein

the requirement specifications are set on a basis of a result of the manual culturing test.

8 . The culturing apparatus setup method according to claim 1 , wherein

the test culturing apparatus and the customized culturing apparatus are physically different apparatuses that satisfy sameness of specifications.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 25, 2024
From: HITACHI, LTD.
To: HITACHI HIGH-TECH CORPORATION
Reel/Frame 068078/0381 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 22, 2022
From: KOBAYASHI, TOYOSHIGE
To: HITACHI, LTD.
Reel/Frame 059332/0166 →
Priority Claims (1)
JP 2019-183587 · Oct 4, 2019 · national
Continuity (1)
Related Publication 20220340862A1 · Oct 27, 2022
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